Protein Alignment PlexA and PLXNA3

DIOPT Version :10

• Sequence 1: NP_524637.2
• Gene: PlexA / 43832
• FlyBaseID: FBgn0025741
• Length: 1945
• Species: Drosophila melanogaster
• Sequence 2: NP_059984.3
• Gene: PLXNA3 / 55558
• HGNCID: 9101
• Length: 1871
• Species: Homo sapiens
• Alignment Length: 1939
• Identity: 776/1939 - (40%)
• Similarity: 1117/1939 - (57%)
• Gaps: 163/1939 - (8%)

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVR------ 130
            ||.|.||.|..:||.||||.|||:::|:|:|.......|||..|:..|    .|..::|
Human    30 DTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARC----YPPPSMRVCAHRL 90

  Fly   131 SPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSST 188
            :|.||.||:||||.|..||:||||::||.|....|.::..:       ||.:..| ...|:.:..
Human    91 APVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGA-QEPDSMAGV 154

  Fly   189 VAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVT 243
            :.....||.:      ::||......|.|   .|.::||.|    :...||      :..||.:.
Human   155 IVEQGQGPSK------LFVGTAVDGKSEY---FPTLSSRKLISDEDSADMFSLVYQDEFVSSQIK 210

  Fly   244 TGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSH----HSSPKEYITKLVRICQEDSNY 304
            ..:.|.....|.:.|   |:|||.|..|.||||.||....    .:..|.:.:|:||:|..||.:
Human   211 IPSDTLSLYPAFDIY---YIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEF 272

  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNN 367
            |||.|.|:.|   :..|.::.|||:..|.||...|||:||:...:||||.:||:|:.|  :|...
Human   273 YSYVEFPIGC---SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQ 334

  Fly   368 SALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGGE 431
            :.||:::|.:|.....:.|:||:.|.|...|.: ::..:||:.|.:| |..:||||.:|.||||.
Human   335 TILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQ-INGNFCGLVLNQPLGGL 398

  Fly   432 TPITSVPVAMFNTK-LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEIN 495
            ..|..:|:...:|. :.||||.:...::|||:||..|.||||.::....|:.|.:..|..||.|.
Human   399 HVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPIL 463

  Fly   496 RDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDAN 560
            ||:.|...:.:||::|:.:||::.|..|..|::|..|||:.||:||||.|.::|.....|. .|:
Human   464 RDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACL-GAS 527

  Fly   561 DPLYWVSYKTGKCTTITSVVPHQLQRTTART-LELIIDHLPQLKENLICAF--TTEDKALFTNAT 622
            .| :..:.:..||..: .|.|:.:..|:... |.:.:.::|.|...:.|||  ..|::|:...:.
Human   528 AP-HGFAEELSKCVQV-RVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSG 590

  Fly   623 KKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVR---TRNGPDLVSTDFTFFDCSTHSSCTRCVSS 684
            :    :.|.:|....|..:.:| |..|..:.::   ...|......||.|::||...||..||.|
Human   591 E----LLCPSPSLQELRALTRG-HGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGS 650

  Fly   685 EFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGG 745
            .:||.||...|.||....| |              |::.|    |..||.|..:||   :|:..|
Human   651 PYPCHWCKYRHTCTSRPHE-C--------------SFQEGRVHSPEGCPEILPSGD---LLIPVG 697

  Fly   746 TSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQYTSRSPNLT-AT 807
            ..:.:.::...:.| ...|..:.|...::||...:.| :....::.|.:..:.|.......| ..
Human   698 VMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELD 762

  Fly   808 FAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGK 872
            |:|:|.|..|:|.|.:...::|:|.....|||:||....::|||||.|.:.|::...|   ...|
Human   763 FSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHC---PAPK 824

  Fly   873 TDWLNRSE---ICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQF 934
            |:|::.|:   .|.:|.|....|..||.||||.:||.|.|||....::  |:|:||:.|...|..
Human   825 TNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREV--GLRVAGVRCNSIPAE 887

  Fly   935 YIDTKQIVCTVDSPGEQMYRNGKIVVQIG----DYRGESKEDYEFVDPKILDFNPKFGPTSGGTE 995
            ||..::|||.::.........|.:.:.:|    |:|.:|::.|.||.|.....:|..||.||||.
Human   888 YISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTR 952

  Fly   996 IHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASP-GIIEGRLKMSFDNGPREFNDYN 1059
            :.|:|..|:||||:..::.|. .|:.:..|:...:|.:..|. |..:..:.::.|..........
Human   953 LTISGSSLDAGSRVTVTVRDS-ECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLI 1016

  Fly  1060 FKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQS 1124
            :.|..||||.        :::....|..|...|:|:||...::|.|.:...|.|....:.|:|.:
Human  1017 YTYTQDPTVT--------RLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVIN 1073

  Fly  1125 DTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEE--- 1186
            ||.|.|.:|.:.:......|:.....|:|||:|:|...::|::   :.|..||:|.   ||.
Human  1074 DTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNR---SSFTYYPDPS---FEPLGP 1132

  Fly  1187 ----RVKYFKSEYLTINGRNLDRACKES---DVEVKIGNGFCNITSLSRQQLTCRPPSEATATKS 1244
                .||  ...::.:.|:||..|...|   :..|.||...|::| :|..||.|..||:.
Human  1133 SGVLDVK--PGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLT-VSDTQLLCDSPSQT----- 1189

  Fly  1245 MNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSES 1309
             ....|:|.:| .||:.:|.|...:...:.   ...:..:.|...:|||...|:|||||:|:.::
Human  1190 -GRQPVMVLVG-GLEFWLGTLHISAERALT---LPAMMGLAAGGGLLLLAITAVLVAYKRKTQDA 1249

  Fly  1310 SRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDH 1374
            .|.|:.:|.|||.||.|||.|||||||||||::.:||..:....|||||||:||:::|||..|.|
Human  1250 DRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAH 1314

  Fly  1375 IVL-QWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLE 1438
            .|| :.:.|.  ..||.||:||||:.::.|:|.||.|||:...||||:|..||||.||.|||:|:
Human  1315 PVLKELDTPP--NVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLD 1377

  Fly  1439 YCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRA 1503
            |.|.:||.||.|||||.:|.|:|||||||||||||||||:.||||||:|||||||||||::|:.|
Human  1378 YATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCA 1442

  Fly  1504 VKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSH--TENVS 1566
            :|.|::|||:||.|.||||||||:|||||.||::.:.::.             :.|.:  :..|.
Human  1443 IKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHC-------------VCPENEGSAQVP 1494

  Fly  1567 VKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKL 1631
            ||||:||:|.|.|:|.|:|:|:.||.||||:.:|:|||||.|...|:||.|||||:|.|.:||:|
Human  1495 VKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRL 1559

  Fly  1632 NTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSPLNNDM 1696
            |:|.||.|.||:.::|||||.|.||.:..........:||:|   ..|:|||...|:.:|:....
Human  1560 NSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESL---LRTASSPDSLRSRAPMITPD 1621

  Fly  1697 HENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSAL 1761
            .|.|.:.|||||:||....:||:|.:|:||||||||||||||||||||||||||:||||||||||
Human  1622 QETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSAL 1686

  Fly  1762 PLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVV 1826
            ||||||||||||:||....|:||:|.||||||.||||||||:||||.|||||||::|.|:|||||
Human  1687 PLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVV 1751

  Fly  1827 AQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRL 1891
            |||||||||||:|||||||||:|||||||||.|:.||:||||||..|:.||||||:|.|.|:|||
Human  1752 AQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRL 1816

  Fly  1892 HTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMSSE 1945
            |.::|:...||:|||.|..||.:::...|:.|...:|.:|..||||:.:::||:
Human  1817 HASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSD 1870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	165/475 (35%)
		PSI	522..574	CDD:396154	18/51 (35%)
		TIG_plexin	580..670	CDD:465588	19/95 (20%)
		PSI	671..>702	CDD:396154	14/30 (47%)
		TIG_2	738..829	CDD:465619	18/93 (19%)
		PSI	830..883	CDD:396154	18/55 (33%)
		IPT_plexin_repeat1	885..977	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	978..1063	CDD:238584	22/85 (26%)
		IPT	1078..1177	CDD:472823	26/98 (27%)
		TIG	<1196..>1246	CDD:460355	16/52 (31%)
		Plexin_cytopl	1353..1911	CDD:462434	342/560 (61%)
PLXNA3	NP_059984.3	Sema_plexin_A3	21..489	CDD:200534	167/479 (35%)
		PSI	490..>527	CDD:396154	15/37 (41%)
		TIG_plexin	546..636	CDD:465588	19/94 (20%)
		PSI	637..684	CDD:396154	19/61 (31%)
		TIG_2	690..784	CDD:465619	20/96 (21%)
		PSI	788..837	CDD:396154	17/51 (33%)
		IPT_plexin_repeat1	840..934	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	935..1021	CDD:238584	23/86 (27%)
		IPT_plexin_repeat3	1023..1123	CDD:238586	29/110 (26%)
		IPT_PCSR	1125..1208	CDD:238337	27/95 (28%)
		Plexin_cytopl	1293..1836	CDD:462434	342/560 (61%)