DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexA and PLXNB3

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_001156729.1 Gene:PLXNB3 / 5365 HGNCID:9105 Length:1932 Species:Homo sapiens


Alignment Length:2025 Identity:667/2025 - (32%)
Similarity:989/2025 - (48%) Gaps:281/2025 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PINLTNANAPIKNAKNLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVK 109
            |:.||.|:              ..:|.:|.||||.:....|.::||.||||:||||:|:|.....
Human    61 PLPLTGAH--------------RFSAPNTTLNHLALAPGRGTLYVGAVNRLFQLSPELQLEAVAV 111

  Fly   110 TGPQNDSVEC----SILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSI 170
            |||..||.:|    ...:||...:   |||.|::||:......|:|||.:.||.|..|.|.:|:.
Human   112 TGPVIDSPDCVPFRDPAECPQAQL---TDNANQLLLVSSRAQELVACGQVRQGVCETRRLGDVAE 173

  Fly   171 IEHEVPDA-----VVANDANSSTVAFIAPGPPQHPVTNVMYV--GVTYTNNSPYRSEIPAVASRS 228
            :.::..|.     |.||....:||..:.|.|.:    :::.|  |:.    ....:.:|.:|.|.
Human   174 VLYQAEDPGDGQFVAANTPGVATVGLVVPLPGR----DLLLVARGLA----GKLSAGVPPLAIRQ 230

  Fly   229 LEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITK 293
            |..::.|    |:...| |..:..::  .|..:||..|:..|.:||:   .:.....:..||.:.
Human   231 LAGSQPF----SSEGLG-RLVVGDFS--DYNNSYVGAFADARSAYFV---FRRRGARAQAEYRSY 285

  Fly   294 LVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSK 358
            :.|:|..|:|.|||.|:|:.|  ..||     |:||.||. |.:              |..||:.
Human   286 VARVCLGDTNLYSYVEVPLAC--QGQG-----LIQAAFLA-PGT--------------LLGVFAA 328

  Fly   359 GEGNTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPS------------MPCVLTK 411
            |...|   .:|||.:.:..:.....|..:.|:...| ||     ||            ..||...
Human   329 GPRGT---QAALCAFPMVELGASMEQARRLCYTAGG-RG-----PSGAEEATVEYGVTSRCVTLP 384

  Fly   412 LQTIGEDFCGLD-VNSPLGGETPITSVPVAMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIE 475
            |.:.....||.: ..||:.|..|:...|:......:::|||....|:.:.|:|.:.|.|.||.:.
Human   385 LDSPESYPCGDEHTPSPIAGRQPLEVQPLLKLGQPVSAVAALQADGHMIAFLGDTQGQLYKVFLH 449

  Fly   476 SSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYC 540
            .|.....::......||.|:.|:..|:...::||::..:|.::.|..|..:..|..||.|:||.|
Human   450 GSQGQVYHSQQVGPPGSAISPDLLLDSSGSHLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLC 514

  Fly   541 GWCSLENKCSPRSNC--QDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQL- 602
            |||.|:.:|:.:..|  ....|..| |...:...|..|.|::|....|.....:.|.:..||.| 
Human   515 GWCVLQGRCTRKGQCGRAGQLNQWL-WSYEEDSHCLHIQSLLPGHHPRQEQGQVTLSVPRLPILD 578

  Fly   603 -KENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTD 666
             .|...|||...|.........    |.|.||..|.:|....|..|.|..|::...: ..:.:|:
Human   579 ADEYFHCAFGDYDSLAHVEGPH----VACVTPPQDQVPLNPPGTDHVTVPLALMFED-VTVAATN 638

  Fly   667 FTFFDCS------THSSCTRCVSSEFPCDWCVEAHRCTHDTAENC-RNDILVTGVSRIGPSYRSG 724
            |:|:|||      ..:.|..||.|.:.|.||.::..|.:  .|:| ..:..:.....:....| |
Human   639 FSFYDCSAVQALEAAAPCRACVGSIWRCHWCPQSSHCVY--GEHCPEGERTIYSAQEVDIQVR-G 700

  Fly   725 PGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFI-VQTRFVCQFNIEGRVTSLNAQL---LG 785
            ||.||.:.  |.....||..|....:.::|..:..|. :...|.|...:.|.:..|.|.|   .|
Human   701 PGACPQVE--GLAGPHLVPVGWESHLALRVRNLQHFRGLPASFHCWLELPGELRGLPATLEETAG 763

  Fly   786 DT--IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKY 848
            |:  |:|.:.:|..:.....|.....|..|.::.|||.|.::|::|.|......|..|.|.:...
Human   764 DSGLIHCQAHQFYPSMSQRELPVPIYVTQGEAQRLDNTHALYVILYDCAMGHPDCSHCQAANRSL 828

  Fly   849 NCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGK 912
            .|.||:... .|.....|   ..|..:.|     ||.|.|...:|.|||.|||..:||.|.|||:
Human   829 GCLWCADGQPACRYGPLC---PPGAVELL-----CPAPSIDAVEPLTGPPEGGLALTILGSNLGR 885

  Fly   913 NYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQI-GDYRGESKEDYEFV 976
            .:.|:...|.:|...|.|.|..|..:.:||| |.||... ...|.:.|.| ....|.|.:.:.:.
Human   886 AFADVQYAVSVASRPCNPEPSLYRTSARIVC-VTSPAPN-GTTGPVRVAIKSQPPGISSQHFTYQ 948

  Fly   977 DPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAI-CRT--SASPG 1038
            ||.:|..:|::||.:|||::.|.|:||..|....|.:... ||.||.....:|| |||  .|:||
Human   949 DPVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQ-PCPILEPVCPEAIVCRTRPQAAPG 1012

  Fly  1039 IIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQ 1103
              |..:.:.|.:..|......|:|..:|.:  |::.||...:      .||..|.|.||....:|
Human  1013 --EAAVLVVFGHAQRTLLASPFRYTANPQL--VAAEPSASFR------GGGRLIRVRGTGLDVVQ 1067

  Fly  1104 NP--NIYVVYNGEMYAS-----------------------------------PCRVQSDTEMECA 1131
            .|  ::::..:.|:.||                                   .|.|.|.:.:.|.
Human  1068 RPLLSVWLEADAEVQASRAQPQDPQPRRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCR 1132

  Fly  1132 SPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEE-------RVK 1189
            ||.|...:|   .:|..     |.:||| :|...|......|...|||.......       |:|
Human  1133 SPAVPDRAH---PQRVF-----FTLDNV-QVDFASASGGQGFLYQPNPRLAPLSREGPARPYRLK 1188

  Fly  1190 YFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNG-PEVIVR 1253
              ....|.:.|..|:....:.:|.|.||.|.|.:.:|:|..|.|.||:.|....:.:| |:.:|:
Human  1189 --PGHVLDVEGEGLNLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAHAPQPANGSGLPQFVVQ 1251

  Fly  1254 IGTSLEYRIGILSYESS------NIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRV 1312
            :| :::..:|.:.||:.      .:....|..:..||:...|:||.:.      |:.||.::.|.
Human  1252 MG-NVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAAVLIAAVLLLTLM------YRHKSKQALRD 1309

  Fly  1313 LRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVL 1377
            .:.:..|::.||..|..:|::.|.:|.||||||:.||...||||||||:||.:..||.| ....|
Human  1310 YQKVLVQLESLETGVGDQCRKEFTDLMTEMTDLSSDLEGSGIPFLDYRTYAERAFFPGH-GGCPL 1373

  Fly  1378 QWERPE-------LLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQS 1435
            | .:||       .....:||.....|:.:|.|||..|.|||....||.|:|.:||||:.:.|..
Human  1374 Q-PKPEGPGEDGHCATVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHG 1437

  Fly  1436 KLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYML 1500
            ||||.|||::||||||....:.  .:|||:|||||::.||:|:.|.:..||.||:|.||||||||
Human  1438 KLEYLTDIMRTLLGDLAAHYVH--RNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYML 1500

  Fly  1501 FRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLP------ 1559
            |||::.|||||||||.|.:|:.:|::.:|:|:.::|:|:.:...:            .|      
Human  1501 FRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLMVLV------------GPGAGGAA 1553

  Fly  1560 --SHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTS 1622
              |..:.|..:|||.|||.|||||.|:.:|:..|.||||....||||||:|..|.:.|.|||:||
Human  1554 GSSEMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDLTS 1618

  Fly  1623 KTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSR 1687
            .|::.||:|||||||.|||||.:.|||                :.|:..|::.| .....|....
Human  1619 VTQNHWKRLNTLQHYKVPDGATVGLVP----------------QLHRGSTISQS-LAQRCPLGEN 1666

  Fly  1688 AGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVN------------KLVSEIYLTRLLATKGTL 1740
            .  |...|..|.|:..|||||   :..:.||.:|.            |.:.||||||||:.||||
Human  1667 I--PTLEDGEEGGVCLWHLVK---ATEEPEGAKVRCSSLREREPARAKAIPEIYLTRLLSMKGTL 1726

  Fly  1741 QKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIK 1805
            ||||||.|:.|.|.   ...:|:|:||:||.||:.|:.|||.||..:|.||:|||.||||||.:|
Human  1727 QKFVDDTFQAILSV---NRPIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALK 1788

  Fly  1806 NPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDI 1870
            ||..:||:..|:.||:.|:|:||||:|||:||:|::|:|||.:|||||::||.|::.|:|||.||
Human  1789 NPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADI 1853

  Fly  1871 RDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKL 1935
            |..||.|.|:||:.|||.|..:|:..:...||.|||.:..:|.:|:...||||...||.:||.:|
Human  1854 RQSSPASYQEMNSALAELSGNYTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRL 1918

  Fly  1936 EQVHNIMSSE 1945
            :||..::.::
Human  1919 QQVAALVENK 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 130/468 (28%)
PSI 522..574 CDD:279745 17/53 (32%)
PSI 671..>699 CDD:279745 11/33 (33%)
PSI 830..883 CDD:279745 11/53 (21%)
IPT_plexin_repeat1 885..977 CDD:238585 33/92 (36%)
IPT_plexin_repeat2 978..1063 CDD:238584 30/87 (34%)
IPT 1078..1177 CDD:301692 27/135 (20%)
IPT_PCSR 1196..>1255 CDD:238337 19/59 (32%)
Plexin_cytopl 1353..1916 CDD:285529 267/589 (45%)
PLXNB3NP_001156729.1 Sema_plexin_B3 70..495 CDD:200538 132/476 (28%)
PSI 497..548 CDD:279745 17/51 (33%)
IPT_plexin_repeat1 858..949 CDD:238585 33/92 (36%)
IPT_plexin_repeat2 950..1035 CDD:238584 30/87 (34%)
IPT 1038..1169 CDD:301692 31/147 (21%)
TIG <1199..1265 CDD:280079 19/66 (29%)
Plexin_cytopl 1350..1899 CDD:285529 267/589 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I9806
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.820

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