DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and PLXNA2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_005273221.1	Gene:	PLXNA2 / 5362	HGNCID:	9100	Length:	1974	Species:	Homo sapiens

Alignment Length:	2034	Identity:	813/2034 - (39%)
Similarity:	1148/2034 - (56%)	Gaps:	282/2034 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTD 134
            |...|||.|...||.|:||.:||:|:|:.:|.:....||||:.|:..|  .::..|.:.|.:.|:
Human    62 DWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTN 126

  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD---------AVVAND 183
            |.||:|:||.:.:||:|||||:||.|.:..|.::.|:       ||.:..         .:|.::
Human   127 NVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSE 191

  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAV 242
            .....                :::|........|   .|.::||.|    |.:.|  :::.|..|
Human   192 GEDGK----------------LFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFV 237

  Fly   243 TTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLKHSHHSSPKE----------YITKLVR 296
            ::..:...::.|..::| :.|:|||:|..|.||||.|     ..:|:.          |.:::||
Human   238 SSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQ-----PETPEGVAINSAGDLFYTSRIVR 297

  Fly   297 ICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG 361
            :|::|..::||..:|..|   .:.|.::.|:||.:|.||...|||:..|:.|||||||:||||:.
Human   298 LCKDDPKFHSYVSLPFGC---TRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQK 359

  Fly   362 --NTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGL 422
              :.|.::||||.:.:::|..:..:.::||:.|.|...|:: :...:.|  ||... |.::||||
Human   360 QYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQC--TKAPVPIDDNFCGL 422

  Fly   423 DVNSPLGGETPITSVPVAMFNT---KLTSVAATSTSGYTVVFVGTSDGFLKKVVIES---SSIAN 481
            |:|.||||.||:..  :.::.|   ::||||:...:||:||||||..|.|||:..:.   ..:..
Human   423 DINQPLGGSTPVEG--LTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQY 485

  Fly   482 EYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLE 546
            |..|...| ||.|.|||.|.....|:||||:.:|::|.|..|..|.|||:||.:.||:||||:|.
Human   486 EMVSVLKD-GSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALH 549

  Fly   547 NKCSPRSNCQDDANDPLYWVSYKTGKCTTIT------SVVPHQLQRTTARTLELIIDHLPQLKEN 605
            |.||.|..|| .|.:|..:.: ...:|.::.      ||..|      :|.|.|::...|.|...
Human   550 NMCSRRDKCQ-QAWEPNRFAA-SISQCVSLAVHPSSISVSEH------SRLLSLVVSDAPDLSAG 606

  Fly   606 LICAFTTEDKALFTNATKKRNGVN-----CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVS 664
            :.||        |.|.|:....|:     |.:|....:|.|...:..|..:|.:|:: .|...||
Human   607 IACA--------FGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVS 663

  Fly   665 TDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----P 725
            |:|.|::||.|..|..||:|.|.|.||...:.||||.. .|              |::.|    .
Human   664 TEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TC--------------SFQEGRINIS 713

  Fly   726 GFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTI 788
            ..||.:..|   .|:|:..|..|.|.:|...:.| ...|..:.|..||:|.:..:.| :....::
Human   714 EDCPQLVPT---EEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSV 775

  Fly   789 YCDSMEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGW 852
            .|.:..:||.... .||...|||:|.|:..:|||.::.|.:|:|....:|||:||....|:.|||
Human   776 QCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGW 840

  Fly   853 CSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDI 917
            ||....|.:.:.|........||.:.:..|.||:|......:||.||||.:||.|:|||.::::|
Human   841 CSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEI 905

  Fly   918 YSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY--RNGKIVVQIGDYRGE----SKEDYEFV 976
            ...|::||:.|.|.|..||..:||||.:   |..:.  .:|.:.:.||:.:.|    |.:.|.||
Human   906 AHHVQVAGVPCTPLPGEYIIAEQIVCEM---GHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFV 967

  Fly   977 DPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAIC-RTSASPGII 1040
            :|.:|..||..||.||||.:.|||.:|.|||.:...:.:. .|:......|:.:| ...:|.|:.
Human   968 NPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQ-TCEFYGRSMSEIVCVSPPSSNGLG 1031

  Fly  1041 EGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQN 1104
            ...:.:|.|....:.| ..|:|:.||.|:.:.         |: .|.:|...:::||.....||.
Human  1032 PVPVSVSVDRAHVDSN-LQFEYIDDPRVQRIE---------PEWSIASGHTPLTITGFNLDVIQE 1086

  Fly  1105 PNIYVVYNGEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSK 1167
            |.|.|.:||:...:.|:|.:.|.:.|.:|.:..|..  :...|||.  |:||:.:|   ||:|..
Human  1087 PRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPD--EFGFVFNN---VQSLLI 1146

  Fly  1168 VHNNHFELYPNPEYFIFEER--VKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNIT 1224
            .::..|..||||.:.:....  :.......:.:.|:||   |..:      :..|.||...|.:|
Human  1147 YNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNL---CPPASGGAKLNYTVLIGETPCAVT 1208

  Fly  1225 SLSRQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATI 1288
             :|..||.|.||       ::.|. :|:|.:| .:.:..|.:|..|.:::.   ...|.::.|..
Human  1209 -VSETQLLCEPP-------NLTGQHKVMVHVG-GMVFSPGSVSVISDSLLT---LPAIVSIAAGG 1261

  Fly  1289 VILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGG 1353
            .:||:|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...|
Human  1262 SLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSG 1326

  Fly  1354 IPFLDYRSYAMKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRTL 1411
            ||:||||:|||::|||..|||.||:    ||       ...||.|::|.|||.||.|||.|||||
Human  1327 IPYLDYRTYAMRVLFPGIEDHPVLR----ELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTL 1387

  Fly  1412 ESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKM 1476
            |..|.||||:|.|||||||..||.:|||.||:||.||.|||:|.:|.|:||||||||||||||||
Human  1388 ELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKM 1452

  Fly  1477 LSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNV 1541
            |:.||.|||:|||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.|:
Human  1453 LTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIE------ 1511

  Fly  1542 YASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWR 1606
            |.::|   :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:|||||
Human  1512 YKTLI---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWR 1571

  Fly  1607 TGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYE 1671
            .|...||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|....
Human  1572 QGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASASIS 1629

  Fly  1672 TLNISKYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLT 1731
            ..:||:|.||     ||...|:.:|:.....|:|::.|||||:||...||||:|.:|:|||||||
Human  1630 RTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLT 1694

  Fly  1732 RLLATK----------------------------------------------------------- 1737
            ||||||
Human  1695 RLLATKTLLVLLCSCQEAPSPPACSSDTVSGLACSLCPLIHPWEARTRGTSCLPVKDPEPTPCVE 1759

  Fly  1738 ------GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLP 1796
                  |||||||||||||:|||.||||||||||||||||||:||..|.|.|.:|.||||||.||
Human  1760 CGMWLQGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLP 1824

  Fly  1797 LRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRK 1861
            ||||||:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.|:.
Human  1825 LRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKS 1889

  Fly  1862 WVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFS 1926
            ||:|||.||..:..||||||||.|||:||||..|||...||:|:|:|..||:|:|...||:||.:
Human  1890 WVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQA 1954

  Fly  1927 QKQRLAFKLEQVHNIMSSE 1945
            ::||||:|:||:.|.||.|
Human  1955 RRQRLAYKVEQLINAMSIE 1973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	160/489 (33%)
		PSI	522..574	CDD:279745	22/51 (43%)
		PSI	671..>699	CDD:279745	12/27 (44%)
		PSI	830..883	CDD:279745	16/52 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	978..1063	CDD:238584	26/85 (31%)
		IPT	1078..1177	CDD:301692	29/101 (29%)
		IPT_PCSR	1196..>1255	CDD:238337	18/65 (28%)
		Plexin_cytopl	1353..1916	CDD:285529	360/639 (56%)
PLXNA2	XP_005273221.1	Sema_plexin_A2	53..567	CDD:200533	184/537 (34%)
		PSI	670..717	CDD:279745	18/61 (30%)
		PSI	821..870	CDD:279745	15/48 (31%)
		IPT_plexin_repeat1	873..968	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	969..1052	CDD:238584	26/84 (31%)
		IPT_plexin_repeat3	1056..1156	CDD:238586	31/113 (27%)
		TIG	1158..1242	CDD:280079	21/95 (22%)
		Plexin_cytopl	1326..1944	CDD:285529	360/639 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	709	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1366	1.000	Inparanoid score	I130
Isobase	1	0.950	-	0	Normalized mean entropy	S4424
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm41887
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810