DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and PLXNA1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_115618.3	Gene:	PLXNA1 / 5361	HGNCID:	9099	Length:	1896	Species:	Homo sapiens

Alignment Length:	1966	Identity:	820/1966 - (41%)
Similarity:	1129/1966 - (57%)	Gaps:	208/1966 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 AAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAV 129
            :|.|..|.||:|...||.|:||.|||:|:||.:|.|.....|||..|:.:|    |:..||...
Human    45 SASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGL- 108

  Fly   130 RSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSS 187
             ..|||.||:||:|.|.:||:||||..||.|....|.::..:       ||.:..   ..:|.|.
Human   109 -GSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSS---VQEAGSM 169

  Fly   188 TVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAV 242
            ....|| |||...... ::||......|.|   .|.::||.|    |...||      :..||.:
Human   170 AGVLIA-GPPGQGQAK-LFVGTPIDGKSEY---FPTLSSRRLMANEEDADMFGFVYQDEFVSSQL 229

  Fly   243 TTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKE-----YITKLVRICQEDS 302
            ...:.|.....|.:.|   |||.|.||:|.|:||.|| .:..:||..     :.:|:||:|.:|.
Human   230 KIPSDTLSKFPAFDIY---YVYSFRSEQFVYYLTLQL-DTQLTSPDAAGEHFFTSKIVRLCVDDP 290

  Fly   303 NYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPT 365
            .:|||.|.|:.|   .|.|.::.|||..:|.:|...||..||::..:||||.||::|:.|  .|.
Human   291 KFYSYVEFPIGC---EQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPP 352

  Fly   366 NNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLG 429
            ..||||:::|::|:.|..:.|:||:.|.|...|.: ::..:.|:.:.|| |.:||||.|.|.|||
Human   353 KESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQ-IDDDFCGQDFNQPLG 416

  Fly   430 GETPITSVPVAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSS----IANEYASFA 487
            |...|...|  :|..|   ||:|||....|.||||.||..|.::|::::.|:    .|..|.|..
Human   417 GTVTIEGTP--LFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYESVV 479

  Fly   488 VDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPR 552
            ...||.|.||:.....:.|:|.|::.:|::|.|..|..|.:|..|||:|||:||||.|.:.||.|
Human   480 AQEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRR 544

  Fly   553 SNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFT--TE 613
            ..| :.|::|..:.: ...:|..:| |.|..:..|.:: :.|::.  ::|.|...:.|:|.  ||
Human   545 DAC-ERADEPQRFAA-DLLQCVQLT-VQPRNVSVTMSQ-VPLVLQAWNVPDLSAGVNCSFEDFTE 605

  Fly   614 DKALFTNATKKRNGVNCTTPRTDMLPQIEQGK-HHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHS 676
            .:::..:..     ::|.:|....:..|.:|: .....||.:::: .|....|.||.|::||.|.
Human   606 SESVLEDGR-----IHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQ 665

  Fly   677 SCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVL 741
            ||..||:..|||.||...|.|||:.|: |              ::..|     .:|.:.|..::|
Human   666 SCLSCVNGSFPCHWCKYRHVCTHNVAD-C--------------AFLEG-----RVNVSEDCPQIL 710

  Fly   742 VAGGTSKSIKVKVHIIGQFIVQTR-----------FVCQFNIEG---RVTSLNAQLLGDTIYCDS 792
                .|..|.|.|.::....:..|           :.|.|:|.|   |||:|  :....::.|.:
Human   711 ----PSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTAL--RFNSSSLQCQN 769

  Fly   793 MEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSST 856
            ..:.|.... .:|....:|:|.|:..:|||.||...:|:|..:.:|||:||....::.||||.:.
Human   770 SSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAE 834

  Fly   857 NTCEVEEQCNKNKEGKTDWLNR---SEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIY 918
            ..|.:...|  ..:....|::.   |..|.:|:|....|:|||.:|||.:||.|.|||..:.|:.
Human   835 RRCSLRHHC--AADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVR 897

  Fly   919 SGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGD----YRGESKEDYEFVDPK 979
            .|||:..:.|.|....||..:||||.:.........:..:.|.:.|    ||..|.:.:.||.|.
Human   898 LGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPT 962

  Fly   980 ILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRT--SASPG---I 1039
            ....:|..||.||||.|.|.|.||||||.:..|:... ||.....:|.:..|.|  ..|||   |
Human   963 FYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGR-PCSFSWRNSREIRCLTPPGQSPGSAPI 1026

  Fly  1040 IEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQ 1103
            |....:....|...::|     |..|||:..:.         |: .|.:||..::||||...:::
Human  1027 IININRAQLTNPEVKYN-----YTEDPTILRID---------PEWSINSGGTLLTVTGTNLATVR 1077

  Fly  1104 NPNIYVVYNGEMYASPCRVQSDTEMECASPVV--DVDSHVIEAERPILLEYGFLMDNVLRVQNLS 1166
            .|.|...|.|....:.|.|.:||.|.|.:|.|  .|.|.....|||.  |.||:|||   |::|.
Human  1078 EPRIRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPD--ELGFVMDN---VRSLL 1137

  Fly  1167 KVHNNHFELYPNPEYFIFEE-----RVKYFKSEYLTINGRNL---DRACKESDVEVKIGNGFCNI 1223
            .:::..|..||:|   :.|.     .::...|..|.:.||||   .......:..|.||:..|.:
Human  1138 VLNSTSFLYYPDP---VLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTL 1199

  Fly  1224 TSLSRQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIAT 1287
            | :|..||.|..|       ::.|. :|.||.| ..|:..|.|...|.:::          .:..
Human  1200 T-VSETQLLCEAP-------NLTGQHKVTVRAG-GFEFSPGTLQVYSDSLL----------TLPA 1245

  Fly  1288 IV-------ILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDL 1345
            ||       :|||:.||:|:|||:||.::.|.|:.:|.|||.||.|||.|||||||||||::.:|
Human  1246 IVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHEL 1310

  Fly  1346 TGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRT 1410
            |.||...||||||||:|||::|||..|||.||: |.......||.|.:||||:..|.|||.||||
Human  1311 TNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLK-EMEVQANVEKSLTLFGQLLTKKHFLLTFIRT 1374

  Fly  1411 LESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEK 1475
            ||:.|.||||:|.|||||||..||.::||.|.:||.||.|||||.:|.|:|||||||||||||||
Human  1375 LEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEK 1439

  Fly  1476 MLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMN 1540
            ||:.||||||||||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::.:
Human  1440 MLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTL- 1503

  Fly  1541 VYASIIQQPIFCNNLDMLPSHTEN---VSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLD 1602
                         .|:.:....||   |.||.|||||:.|.|||.|:..|:.:|.||||:..|:|
Human  1504 -------------TLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMD 1555

  Fly  1603 LEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKS 1667
            ||||.|...|:||.|||||:|.:::||:||||.||.|.||:.::|||||:|.||.|..|...:..
Human  1556 LEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSL 1620

  Fly  1668 HKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTR 1732
            .:||::   ..|:|||...|:.:|:.....|:|.:.|||||:||...|:||:|.:|:||||||||
Human  1621 SRYESM---LRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTR 1682

  Fly  1733 LLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPL 1797
            |||||||||||||||||||||||||||||||||||||||||:||..|.|.|.:|.||||||.|||
Human  1683 LLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPL 1747

  Fly  1798 RFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKW 1862
            |||||:||||.|||||||::|.|:||||||||||||||||:|:|||||||:|||||||||.|:.|
Human  1748 RFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSW 1812

  Fly  1863 VDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQ 1927
            |:|||.||..|..||||||:|.|||:||||.::||:..||||:|:|..||.:::...||:||.::
Human  1813 VERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDEILAALEKDEQAR 1877

  Fly  1928 KQRLAFKLEQVHNIMS 1943
            :|||..|||||.:.|:
Human  1878 RQRLRSKLEQVVDTMA 1893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	173/480 (36%)
		PSI	522..574	CDD:279745	20/51 (39%)
		PSI	671..>699	CDD:279745	14/27 (52%)
		PSI	830..883	CDD:279745	14/55 (25%)
		IPT_plexin_repeat1	885..977	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	978..1063	CDD:238584	30/89 (34%)
		IPT	1078..1177	CDD:301692	34/101 (34%)
		IPT_PCSR	1196..>1255	CDD:238337	19/62 (31%)
		Plexin_cytopl	1353..1916	CDD:285529	356/565 (63%)
PLXNA1	NP_115618.3	Sema_plexin_A1	38..513	CDD:200532	175/487 (36%)
		PSI	514..>556	CDD:279745	20/42 (48%)
		PSI	660..707	CDD:279745	21/66 (32%)
		PSI	809..862	CDD:279745	14/54 (26%)
		IPT_plexin_repeat1	864..960	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	961..1046	CDD:238584	31/90 (34%)
		IPT_plexin_repeat3	1048..1148	CDD:238586	36/113 (32%)
		TIG	1150..1234	CDD:280079	25/95 (26%)
		Plexin_cytopl	1318..1866	CDD:285529	356/565 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147253
Domainoid	1	1.000	709	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1366	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm41887
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760