DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PlexA and plxna3

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001006866.1	Gene:	plxna3 / 448633	XenbaseID:	XB-GENE-856557	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	131/408 - (32%)
Similarity:	195/408 - (47%)	Gaps:	79/408 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 STITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLN 127
            |.....|..||.|.||.|...||.|::|.|||:::||.:|....:..|||..|:..|    .|..
Frog    21 SVFPTFAVSDTSLTHLAVHKHTGDVYLGAVNRIFKLSENLTELRSHLTGPIADNSSC----YPPP 81

  Fly   128 AVR------SPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEV---- 175
            :||      |||||.|::||||....|::||||::||.|....|.::..:       ||.:
Frog    82 SVRVCTHKLSPTDNVNRLLLIDYTGKRVVACGSVWQGICQFLRLDDLFKLGEPHHRKEHYLSGAR 146

  Fly   176 -PDA----VVANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EK 231
             ||:    :|..|...|.                :::|.:....|.|   .|.::||.|    |.
Frog   147 EPDSMAGVIVDQDVEQSK----------------LFIGTSIDGKSEY---FPTLSSRRLVQDEES 192

  Fly   232 TKMFQI------ASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSH----HSS 286
            .:||::      .||.:...:.|.   ....::.:.|||||.|:.|.||||.||....    .:.
Frog   193 AEMFRLVYQDEFVSSQIKVPSDTL---SLHPSFDIYYVYGFVSKIFVYFLTLQLDTQQTLLDATG 254

  Fly   287 PKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDV 351
            .|.:.:|:||:|..|..:|||.|.|:.|..|   |.::.|:|:.:|.:|...|||:|||...::|
Frog   255 EKFFTSKIVRMCSGDLEFYSYVEFPIGCTKD---GVEYRLIQSAYLSRPGRKLAQALGIPEDEEV 316

  Fly   352 LFAVFSKGEGN--TPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQT 414
            ||.|||:|:.|  .|...|.||:::|..|.......|:||::|.|       ..|:|.:|.|
Frog   317 LFTVFSQGQKNRSNPPRESVLCLFTLSQINLHIKMRIQSCYHGEG-------KLSLPWLLNK--- 371

  Fly   415 IGEDFCGLDVNSPLGGET 432
              |.||...|:..:|..|
Frog   372 --ELFCISTVSGCIGAFT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	127/396 (32%)
		PSI	522..574	CDD:279745
		PSI	671..>699	CDD:279745
		PSI	830..883	CDD:279745
		IPT_plexin_repeat1	885..977	CDD:238585
		IPT_plexin_repeat2	978..1063	CDD:238584
		IPT	1078..1177	CDD:301692
		IPT_PCSR	1196..>1255	CDD:238337
		Plexin_cytopl	1353..1916	CDD:285529
plxna3	NP_001006866.1	Sema	22..>378	CDD:326631	127/396 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	705	1.000	Domainoid score	I123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1383	1.000	Inparanoid score	I130
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm49109
Panther	1	1.100	-	-	O	PTHR22625
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.180