DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and MST1R

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_005265227.2	Gene:	MST1R / 4486	HGNCID:	7381	Length:	1401	Species:	Homo sapiens

Alignment Length:	1340	Identity:	282/1340 - (21%)
Similarity:	451/1340 - (33%)	Gaps:	425/1340 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVRSPTDNYNKVLLIDRATSRLIA 151
            |||...|||:.|.|||:..:::.|||..|....:...|.......|.|...|||::|.|...|::
Human    70 VFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVS 134

  Fly   152 CGSLFQGTCTVRNLQNVSIIEH----------------EVPDAVVANDANSSTVAFIAPGPPQHP 200
            |||..||.|.:.:|:......|                :.||.|.:......||  :..|...:
Human   135 CGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTV--VEQGQASY- 196

  Fly   201 VTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYG 265
                     .|..:|...:...:.:.||:...::...||..........:......:|.:.||:.
Human   197 ---------FYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHS 252

  Fly   266 FSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVEC--------ISDAQGGT 322
            |.:..|.||||.| ..|....|....|:|.|:...:.....|.|:.::|        ....:||.
Human   253 FHTGAFVYFLTVQ-PASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQ 316

  Fly   323 KFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTP--TNNSALCIYSLKSIRRKFMQN 385
            .:.:::........:.||..|.|:...:|||.||..|:...|  ..||.:|.:.:..:.....:.
Human   317 PYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEG 381

  Fly   386 IKSCFNG---SGM-RGLDFI-SPSMPCVLTKLQTIGEDFC----GLDVNSPLGGETPITSVP--- 438
            ::.|...   .|: |||||. |||              ||    ||:..||   .|.....|
Human   382 VERCCESPVHPGLRRGLDFFQSPS--------------FCPNPPGLEALSP---NTSCRHFPLLV 429

  Fly   439 ------VAMFN-----TKLTSVAATSTSGYTVVFVGTSDGFLKKV-VIESSSIANEYASFAV-DL 490
                  |.:||     .::|::..|.....||..:||.||.:.:| ::.|.:.....::|:: |.
Human   430 SSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDS 494

  Fly   491 GSEINRDMQFDNQNLYIYVMSKTKVSKVKVF--DCSDYKTCGDCLGA-RDPYCGWCSLENKCSPR 552
            |..:.||:.....:|..  .|..:|.:|.:.  .|..:.|||.||.| ....||||.  |.|..:
Human   495 GQPVQRDVSRLGDHLLF--ASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCG--NMCGQQ 555

  Fly   553 SNCQDDANDPLYWVSYKTGKC-TTITSVVPHQ--LQRTTARTL----------ELIIDHLPQL-- 602
            ..|..         |::...| ..:|...||.  |:.:|..||          .|:.:...|:
Human   556 KECPG---------SWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTV 611

  Fly   603 -------------------KENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHF 648
                               :::.:..|..|.:.|.|.|....| |:.|.  |:|.|    |||.
Human   612 GQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTN-VSLTV--TNMPP----GKHF- 668

  Fly   649 TAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTG 713
                    |.....|...|:|.:                                    .:|:..
Human   669 --------RVDGTSVLRGFSFME------------------------------------PVLIAV 689

  Fly   714 VSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVK-VHIIGQFIVQTRFVCQFNIEGRVT 777
            ....||  |:| |.|.|:    :|..:.|  |||:::.|. ...:...:.:.:.:|.......|.
Human   690 QPLFGP--RAG-GTCLTL----EGQSLSV--GTSRAVLVNGTECLLARVSEGQLLCATPPGATVA 745

  Fly   778 SLNAQL-LGDTIYCDSMEFQY------TSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMA 835
            |:...| :|......|..|||      .|.|||....               |.|:.|
Human   746 SVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYI---------------NSHITI------- 788

  Fly   836 DSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGG 900
              ||..|..:......:.......| ..||.:.       |...::|..||.....|:  .|..|
Human   789 --CGQHLTSAWHLVLSFHDGLRAVE-SRQCERQ-------LPEQQLCRLPEYVVRDPQ--GWVAG 841

  Fly   901 TNITIRGINLGKNYNDIYSGVRIAGINCMPFP-----------------QF-YIDTKQIVCTVDS 947
             |::.||        |..:|..:.|...:|.|                 :| ||.   :....|.
Human   842 -NLSARG--------DGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIG---LGAVADC 894

  Fly   948 PGEQMYRNGKIVVQIGDYRGESKEDYEF-VDPKILDFNPKFGPTSGGT--------EIHITGKHL 1003
            .|        |.|.:|   |||.: :|| .|..:....|.......|.        |.||.|:.:
Human   895 VG--------INVTVG---GESCQ-HEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVV 947

  Fly  1004 NAG------SRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKY 1062
            ..|      |.:...:   ||..:|....:.|:.                            |.|
Human   948 RPGPDGVPQSTLLGIL---LPLLLLVAALATALV----------------------------FSY 981

  Fly  1063 -------VLDPTVEHVSS--GPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYAS 1118
                   ||.|.:..::|  ..:|...:|                          ::|:|..|.|
Human   982 WWRRKQLVLPPNLNDLASLDQTAGATPLP--------------------------ILYSGSDYRS 1020

  Fly  1119 PCRVQ----------------SDTEMECASPVV--------DVDSHVIEAERPILLEYGFLMDNV 1159
            ...:.                ||:|.|...|::        |:||.::...:.:|:.:..::.:.
Human  1021 GLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHS 1085

  Fly  1160 LRVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNIT 1224
            .||     :...||.:..:.||                     :|:|  ::.::       |.|.
Human  1086 DRV-----IGKGHFGVVYHGEY---------------------IDQA--QNRIQ-------CAIK 1115

  Fly  1225 SLSR----QQLTC--RPPSEATATKSMNGPEVIVRIGTSL 1258
            ||||    ||:..  |   |....:.:|.|.|:..||..|
Human  1116 SLSRITEMQQVEAFLR---EGLLMRGLNHPNVLALIGIML 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	117/483 (24%)
		PSI	522..574	CDD:279745	16/53 (30%)
		PSI	671..>699	CDD:279745	0/27 (0%)
		PSI	830..883	CDD:279745	7/52 (13%)
		IPT_plexin_repeat1	885..977	CDD:238585	26/110 (24%)
		IPT_plexin_repeat2	978..1063	CDD:238584	14/105 (13%)
		IPT	1078..1177	CDD:301692	18/122 (15%)
		IPT_PCSR	1196..>1255	CDD:238337	15/64 (23%)
		Plexin_cytopl	1353..1916	CDD:285529
MST1R	XP_005265227.2	Sema_RON	27..523	CDD:200540	117/484 (24%)
		PSI	526..>565	CDD:279745	15/49 (31%)
		IPT_plexin_repeat1	569..683	CDD:238585	27/129 (21%)
		IPT_plexin_repeat2	684..768	CDD:238584	23/92 (25%)
		IPT	769..860	CDD:214657	26/133 (20%)
		TyrKc	1086..1339	CDD:197581	24/105 (23%)
		PTKc_Met_Ron	1087..1348	CDD:270649	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810