DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and Plxnb3

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:XP_008771853.1 Gene:Plxnb3 / 363517 RGDID:1560615 Length:1920 Species:Rattus norvegicus


Alignment Length:1994 Identity:675/1994 - (33%)
Similarity:1001/1994 - (50%) Gaps:252/1994 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVRSP 132
            :...|||::....|:::||.||.|:||||:||:.....|||..||.:|    .:.:||...:   
  Rat    41 NASFNHLVLAPDQGKLYVGAVNHLFQLSPELEMESVAITGPVIDSPDCVPFRDLAECPQAQL--- 102

  Fly   133 TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDA-----VVANDANSSTVAFI 192
            |||.|::||:......|:|||.:.||.|..|.|.:|:.:.::..|.     |.||....:||..:
  Rat   103 TDNANQLLLVSSRAQELVACGQVRQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLV 167

  Fly   193 APGPPQHPVTNVMYV--GVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSYAR 255
            .|.|.:    :::.|  |:.    ....:.:|.:..|.|...:.|    |:...| |..:..:: 
  Rat   168 VPLPGR----DLLLVARGLA----GKLSAGVPPLTVRQLAGPQPF----SSEGLG-RLVVGDFS- 218

  Fly   256 ETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQG 320
             .|..:||..||....:||:   .:.....:..||.:.:.|:|..|.|.|||.|:|:.|  ..||
  Rat   219 -DYNNSYVGAFSDAHSAYFV---FRRRGARAQTEYRSYVARVCLGDVNLYSYVEVPLTC--HGQG 277

  Fly   321 GTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPTNNSALCIYSLKSIRRKFMQN 385
                 |:||.||.               .|.|...||.|   |....:|||.:.|..:.....|.
  Rat   278 -----LIQAAFLA---------------PDTLLGAFSAG---TSQAQAALCAFPLADLDGSMEQA 319

  Fly   386 IKSCF--NGSGMRGLDFISPSMPCVLTKLQTIGEDF-----CGLD-VNSPLGGETPITSVPVAMF 442
            .:.|:  .|.|..|::..:.... |.::..|:..|.     ||.: ..||:.|..|:.:.|:...
  Rat   320 RRLCYTTGGQGPNGMEEATVEYG-VTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQL 383

  Fly   443 NTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYI 507
            ...:::|||..|.|:|:.|:|.::|.|.||.:.||.....::......||.|:.|:..||...|:
  Rat   384 GQPISAVAALQTDGHTIAFLGDTEGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDNSGDYL 448

  Fly   508 YVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWV-SYKTG 571
            ||::..:|.::.|..|..:..|..||.||||.||||.|:.:|:.|:.| ..|..|..|: ||:..
  Rat   449 YVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRAEC-GRAVQPNQWLWSYEDN 512

  Fly   572 KCTTITSVVPHQLQRTTARTLELIIDHLPQL--KENLICAFTTEDKALFTNATKKRNGVNCTTPR 634
            .|..|.|::|.|..|.....:.|.:..||.|  .|...|||...:..    |..:.:.|.|.||.
  Rat   513 HCLHIQSLLPAQHPRQEHGQITLSVPGLPNLAMDEYFYCAFGDYNSL----AQVEEHHVVCATPP 573

  Fly   635 TDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCS------THSSCTRCVSSEFPCDWCVE 693
            .|.:|....|..|.|..|::...: ..|.:|.|:|:|||      ..:.|..||||.:.|.||.:
  Rat   574 QDRMPPNPPGSDHVTLPLALMFED-VVLAATTFSFYDCSAIQALEVAAPCRTCVSSLWRCHWCPQ 637

  Fly   694 AHRCTHDTAENCRN-----------DILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTS 747
            :..|.:  .|.|..           ||||           .||..||.:.  |..|..||..|..
  Rat   638 SSHCVY--GERCPEGEKAVYSAQEVDILV-----------RGPEACPQVK--GLASPQLVPVGWE 687

  Fly   748 KSIKVKVHIIGQFI-VQTRFVCQFNIEGRVTSLNAQLLGDT------IYCDSMEFQYTSRSPNLT 805
            ..:.:.:..:..|. :...:.|...:.|::..|.| .|.:|      |:|.:.:|..:.....|.
  Rat   688 SHVTLHIENLHYFRGLPALYYCWLELPGKLRKLPA-FLEETSRNSGLIHCQAQQFHPSMSQWELP 751

  Fly   806 ATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNK 869
            ....|..|..:.|||..::||.:|.|......|..|.|.:...:|.||.... .|.....|   .
  Rat   752 VPIYVTRGEIQRLDNTGDLHVTLYDCAMGHPDCSHCQAANGSLSCLWCGDGQPACRYGPLC---P 813

  Fly   870 EGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQF 934
            .|..:     ::||.|.|...:|.|||.|||..|||.|.|||:.:||:.:.|.:||..|.|.|..
  Rat   814 PGAVE-----QLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSL 873

  Fly   935 YIDTKQIVCTVDSPGEQMYRNGKIVVQIGDY-RGESKEDYEFVDPKILDFNPKFGPTSGGTEIHI 998
            |..:.:||| |.||... ..:|.:.|.|... .|.|.:.:.:.||.:|..||::||.:|||::.|
  Rat   874 YRISARIVC-VTSPAPN-GTSGPVQVAIKSRPPGISAQHFTYQDPVLLSLNPQWGPQAGGTQLTI 936

  Fly   999 TGKHLNAGSRIQASINDHLPCKILSTDSSQA-ICRT--SASPGIIEGRLKMSFDNGPREFNDYNF 1060
            .|::|..|..:.|.:.|. ||.|......:| ||.|  ...||  |..:.:.|.:..|:.....|
  Rat   937 HGQYLQTGGNVSAFVGDQ-PCPIQEPVCPEAIICHTMPQMEPG--EAVVFVVFGHVERKLLTTPF 998

  Fly  1061 KYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQS- 1124
            :|..:|.:  |.:.||...:      .||..|.|.||....:..|.:.|....|.......||: 
  Rat   999 RYTANPQL--VEAEPSVSFR------GGGRVIRVRGTGLDVVWQPLLSVWLEDEFQVKALGVQAQ 1055

  Fly  1125 --DTEMECASPVVD------VDSHVIEA-------ERPILLEYG-------------FLMDNVLR 1161
              :....|.:|..|      ::|.:::.       ...:||.:.             |.:|| ::
  Rat  1056 DVNPRRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDGALPKRVFFALDN-MQ 1119

  Fly  1162 VQNLSKVHNNHFELYPNP-------EYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNG 1219
            |...|......|...|||       |......|:|  ....|.:.|..|:....:.:|:|.||:|
  Rat  1120 VDFASASGGQGFLYQPNPRLAPLSHEGITHPYRLK--PGHVLDVEGEGLNLGISKEEVQVHIGDG 1182

  Fly  1220 FCNITSLSRQQLTCRPPSEATATKSMNG--PEVIVRIGTSLEYRIGILSYESSNII--------- 1273
            .|.:.:|:...|.|.||.:|....:.:|  |:.:|::| ::...:|.:.||:..:|         
  Rat  1183 KCLVKTLTLTHLYCEPPQQAPQPTNGSGTLPQFVVQMG-NVRLALGPVQYEAEPMISTFPVEAQV 1246

  Fly  1274 -LDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAE 1337
             |..|..::   ||.:::|.|:       |:.||.::.|..:.:..|::.||..|..:|::.|.:
  Rat  1247 GLGMGAAML---IAAVLLLTLM-------YRHKSKQALRDYQKVLVQLENLETGVGDQCRKEFTD 1301

  Fly  1338 LQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNH-----EDHIVLQWERPELLRKEKGLRIFGQL 1397
            |.|||||||.||.:.||||||||:||.:..||.|     :..:....|....:...:||.....|
  Rat  1302 LMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGPGEEGRRVTVCQGLTQLSNL 1366

  Fly  1398 IMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHP 1462
            :.:|.|||..|.|||....||.|:|.:||||:.:.|.|||||.|||::||||||....:.  .:|
  Rat  1367 LNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVH--KNP 1429

  Fly  1463 KLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEE 1527
            ||:|||||::.||:|:.|.:..||.||||.|||||||||||:|.|||||||||.|.:|:.:|::.
  Rat  1430 KLMLRRTETMVEKLLTNWLSICLYAFLKEVAGEPLYMLFRAIKYQVDKGPVDAVTGKAKRTLNDS 1494

  Fly  1528 KLIRQSIDFRPMNVYASIIQQPIFCNNLDMLP--------SHTENVSVKVLDCDTIGQVKEKCLE 1584
            .|:|:.::|||:.:.|.:            .|        |....|..:|||.|||.|||||.|:
  Rat  1495 HLLREDVEFRPLTLMALV------------GPGAGGAAGNSEVHRVPARVLDTDTITQVKEKVLD 1547

  Fly  1585 TIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVP 1649
            .||:..|.||||....||||||:|..|.:.|.|||:||.|::.||:|||||||.|||||.:.|:|
  Rat  1548 QIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVVLIP 1612

  Fly  1650 KQSSIYNFSILSDKNEKS--HKYETLNISKYTS--SSPTFSRAGSPLNNDMHENGLRYWHLVK-- 1708
            :   ::|...:|...|::  |..|:.::|...|  ..|... :.:|:..|..|.|:|.|||||  
  Rat  1613 Q---LHNGGTVSQSLEQTGCHSGESESLSPDLSICQEPQLC-SDTPMLEDGEEGGVRLWHLVKAT 1673

  Fly  1709 --------HHDSDMQKEGERVN-KLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLA 1764
                    ...|..::|.||.. |.:.||||||||:.||||||||||.|:.|.|   ....:|:|
  Rat  1674 EETEGAKVRRSSLRERERERARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILS---MNRPVPIA 1735

  Fly  1765 IKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQT 1829
            :||:|||||:.|:.|||.|||.:|.||:|||.||||||.:|||..:||:..|:..|:.|:|:|||
  Rat  1736 VKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNEDAILAVIAQT 1800

  Fly  1830 FMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTT 1894
            |:|||..|:|::|:|||.:|||||::||.|::.|::||.|||..||.|.|:||:.|||.|..:|:
  Rat  1801 FIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYTS 1865

  Fly  1895 EFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQV 1938
            ..|...||.|||.:..:|.:|:...||||..:||.:||.:|:||
  Rat  1866 APNCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQV 1909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 131/463 (28%)
PSI 522..574 CDD:279745 21/52 (40%)
PSI 671..>699 CDD:279745 12/33 (36%)
PSI 830..883 CDD:279745 10/53 (19%)
IPT_plexin_repeat1 885..977 CDD:238585 36/92 (39%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/87 (32%)
IPT 1078..1177 CDD:301692 23/127 (18%)
IPT_PCSR 1196..>1255 CDD:238337 18/60 (30%)
Plexin_cytopl 1353..1916 CDD:285529 275/590 (47%)
Plxnb3XP_008771853.1 Sema_plexin_B3 37..462 CDD:200538 131/467 (28%)
PSI 464..514 CDD:279745 21/50 (42%)
PSI 622..658 CDD:214655 11/37 (30%)
IPT_plexin_repeat1 824..915 CDD:238585 36/92 (39%)
IPT_plexin_repeat2 916..1001 CDD:238584 28/87 (32%)
IPT 1004..1135 CDD:301692 27/139 (19%)
TIG <1165..1232 CDD:280079 18/67 (27%)
Plexin_cytopl 1317..1887 CDD:285529 275/590 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.920

Return to query results.
Submit another query.