DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and Plxnc1

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:XP_038936027.1 Gene:Plxnc1 / 362873 RGDID:1307420 Length:1759 Species:Rattus norvegicus


Alignment Length:1949 Identity:497/1949 - (25%)
Similarity:788/1949 - (40%) Gaps:565/1949 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 NRLYQLSPDL--ELSETVKTGPQNDSVECSILDCPLNAVRSPTDNYNKVLLIDR--AT--SRLIA 151
            |||.:|..|.  ..:|.|...|.              |...|..:::|:||..|  ||  ..|:.
  Rat   259 NRLSRLYRDQAGNCTEPVSLAPP--------------ARPRPGSSFSKLLLPYREGATGLEGLLL 309

  Fly   152 CGSLF-QGTCTVRNLQNVSIIEHEVPDAVVANDANSST--VAFIAPGPPQHPVTNVMYVGV--TY 211
            .|..| :|.|.||.|.|::.........||:.....||  |.:.|.|      |::.|:.|  ||
  Rat   310 TGWTFDRGACEVRPLGNLNRSSLRNGTEVVSCHPQGSTAGVVYRASG------TDLWYLAVAATY 368

  Fly   212 TNNSPYRSE--IPAVASR----SLEKTKMFQIASSAV-------TTGTRTFINSYA--RETYFVN 261
            ....|..:.  .||.:.|    :|:.|:...:|:..:       :.|:..|::::.  ...||..
  Rat   369 VLPEPETANRCNPAASDRDTAIALKNTEGRSLATQELGRLKLRGSAGSLHFVDAFLWNGSVYFPY 433

  Fly   262 YVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEI------PVECISDAQG 320
            |.|.::|...:.:                 ..:.||.|.       ||:      .::|......
  Rat   434 YPYNYTSGAATGW-----------------PSMARIAQS-------TEVLFQGQAALDCGHGHPE 474

  Fly   321 GTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFS--KGEGNTPTN--NSALCIYSLKSIRRK 381
            |.:..|         ||.|.:::      |:...|||  .|||....:  .:|||::.:..|:.:
  Rat   475 GRRLLL---------SSSLVEAV------DIWAGVFSAATGEGQEKRSPATTALCLFRMSEIQAR 524

  Fly   382 FMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVPVA---MFN 443
                .:||       ..||.:....|                    ..|:.|....|:|   :.:
  Rat   525 ----ARSC-------SWDFQATEHNC--------------------KEGDQPEQVQPIASSTLIH 558

  Fly   444 TKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRD-------MQFD 501
            :.||||..|......|:|:||.||.|.|||:..:..:|     ..::..||..:       :...
  Rat   559 SDLTSVYGTVVMNRIVLFLGTGDGQLLKVVLGENLTSN-----CPEVIYEIKEETPVFYKLVPHP 618

  Fly   502 NQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWV 566
            .::.|||:.:..:|.:::|.:||..|:|..||.|.||:||||....:|:.:.:| ..|.....|:
  Rat   619 VKDTYIYLTAGKEVRRIQVANCSKRKSCFQCLAAADPHCGWCLPLQRCTFQGDC-THAGSFENWL 682

  Fly   567 SYKTG--KCTTITSVVPHQLQRTT--------ARTLELIIDHLPQLKENLICAFTTEDKALFTNA 621
            ...:|  ||..| .::....:|||        ||..|.::.:....|  |:|             
  Rat   683 DISSGPKKCPKI-QIIRSLRERTTVTIVGSVSARHSECVVKNADTGK--LLC------------- 731

  Fly   622 TKKRNGVN----CTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFT-----------FFD 671
             :.|:.:|    |..|.                    |..|...:|:..||           |.:
  Rat   732 -QGRSQMNRTCACNIPS--------------------RPSNNVFVVNATFTFPSWSVSERFNFTN 775

  Fly   672 CSTHSSCTRCVSSEFPCDWCVEAHRCTH-----DTAENCRNDILV----------TGVSRIGPSY 721
            |::...|..|:  |..|.||....||.|     :.::..||..|.          :|..|:..|.
  Rat   776 CASVRECPACI--ETGCAWCKRDKRCIHPFTPCEPSDYERNQELCHVAVEKPPKDSGGGRVKESK 838

  Fly   722 RSGPGFCPTINATGDGSEVLVAGGTSKSIK-VKVHIIGQ---FIVQTRFVCQFNIEGRVTSLNAQ 782
            |         |.|....:|...    |:|: .|:..:|:   .:....|....||        ..
  Rat   839 R---------NRTDPALQVFYI----KAIEPQKISTLGKSNVIVTGANFTQASNI--------TM 882

  Fly   783 LLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEK 847
            :|..|..|:....:.                 |..|::.|....:....:||.|   :|:    :
  Rat   883 ILRGTSTCEKDVIRV-----------------SHVLNDTHMKFSLPSSRKEMKD---VCI----Q 923

  Fly   848 YNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGK 912
            ::.|.|||.              |...::      ..|......|.|....||.||||    :|:
  Rat   924 FDGGNCSSA--------------GALSYI------ALPHCSLIVPATTWISGGQNITI----MGR 964

  Fly   913 NYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGESKEDYEFVD 977
            |: |:...:.|:                         .::..|..:.:.:.:|.  ......|:.
  Rat   965 NF-DVIDNLIIS-------------------------HELKGNINVSINVSEYC--MATSCRFLA 1001

  Fly   978 PKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEG 1042
            |.:   ....|.|:...::.:...:|:.|:                                   
  Rat  1002 PNL---KSSKGRTNVVVKLRVQDTYLDCGT----------------------------------- 1028

  Fly  1043 RLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNI 1107
               :.:...|| |..|..:..:|..:|         :|:.|                   :|.|.
  Rat  1029 ---LQYLEDPR-FTGYRVESEIDTELE---------VKIQK-------------------ENDNF 1061

  Fly  1108 YVVYNGEMYASPCRVQSDTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNH 1172
                         .:..|          |:|..:...|..   ::....:|:.|.|:|:.:    
  Rat  1062 -------------NISRD----------DIDITLFHGENK---QFNCSFENITRNQDLTTI---- 1096

  Fly  1173 FELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCRPPS 1237
                                                           .|.|.|:....      :
  Rat  1097 -----------------------------------------------LCKIKSIKNAN------T 1108

  Fly  1238 EATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAY 1302
            .||::|     :|.|::| :||     |..|..::...|     :.:||..::|.::.|..:|..
  Rat  1109 IATSSK-----KVRVKLG-NLE-----LYVEQESVPSTW-----YFLIALPILLAIVIVVAVVVT 1157

  Fly  1303 KKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKIL 1367
            :.||.|.|   |...:|:::||..:..|.::.|||||.:..|:....  |.:|||||:.:|::..
  Rat  1158 RHKSKELS---RKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSF--GTVPFLDYKHFALRTF 1217

  Fly  1368 FPNHE--DHIVLQ-WERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLI 1429
            ||...  .||..: ....:...|.:.|.....||.||:||:..|.|||..:.||:::|...||.:
  Rat  1218 FPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFL 1282

  Fly  1430 MVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAG 1494
            .:.||:||.|.|.||:.|..||:|:|  ....|||:|||||||.||:|:.|.:..|..||:|..|
  Rat  1283 TIALQTKLVYLTSILEVLTRDLMEQC--SNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVG 1345

  Fly  1495 EPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFR--PMNVYASIIQQPIFCNNLDM 1557
            ||.|:|...:..:::|||||..|.:|.|:|:|:.|:.|..:|.  .:||        :|    :.
  Rat  1346 EPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNV--------VF----EK 1398

  Fly  1558 LPSH-----TENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYD 1617
            :|.:     ..|:||.|||||||||.|||..:.......|....:.:::.||.:.|...:.:|  
  Rat  1399 IPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRQKELL-- 1461

  Fly  1618 EDVTSKT---ESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYT 1679
             |:.|.:   |....||||:.||.:.:|:.:.:..|   |.||:  ||.     :|...:.....
  Rat  1462 -DIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKK---IANFT--SDV-----EYSDDHCHLIL 1515

  Fly  1680 SSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFV 1744
            ..|..|...          .|.|  |..||...            |.|:|||:||:||..:...:
  Rat  1516 PDSEAFQVV----------QGKR--HRGKHKFK------------VKEMYLTKLLSTKVAIHSVL 1556

  Fly  1745 DDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNF 1809
            :.||.:|:|..:  |..|.||||.|||||.||:...||||:|||.||:||||||||||::|||.|
  Rat  1557 EKLFRSIWSLPN--SRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQF 1619

  Fly  1810 VFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMS 1874
            ||||.|:..:||||||:||.|||:.|.::.:|||::|::|||||||||.|::.|..||:.|||:.
  Rat  1620 VFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLP 1684

  Fly  1875 PISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEED---EFSQKQRLAFKL 1935
            |:|..:|...|.:||:.|..|||...||.|:|.|.|||.:::...||.:   |.:|||.|..|:
  Rat  1685 PLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKV 1748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 104/472 (22%)
PSI 522..574 CDD:279745 19/53 (36%)
PSI 671..>699 CDD:279745 9/27 (33%)
PSI 830..883 CDD:279745 9/52 (17%)
IPT_plexin_repeat1 885..977 CDD:238585 16/91 (18%)
IPT_plexin_repeat2 978..1063 CDD:238584 9/84 (11%)
IPT 1078..1177 CDD:301692 12/98 (12%)
IPT_PCSR 1196..>1255 CDD:238337 8/58 (14%)
Plexin_cytopl 1353..1916 CDD:285529 228/575 (40%)
Plxnc1XP_038936027.1 Sema_plexin_C1 229..638 CDD:200507 104/473 (22%)
PSI 639..692 CDD:396154 19/53 (36%)
PSI 775..819 CDD:396154 13/45 (29%)
TIG 851..937 CDD:396414 22/135 (16%)
IPT 940..1032 CDD:214657 21/164 (13%)
Plexin_cytopl 1203..1726 CDD:400574 228/575 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D90434at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.020

Return to query results.
Submit another query.