DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Plxna1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_002729444.2	Gene:	Plxna1 / 362398	RGDID:	1560871	Length:	1912	Species:	Rattus norvegicus

Alignment Length:	1962	Identity:	818/1962 - (41%)
Similarity:	1129/1962 - (57%)	Gaps:	202/1962 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 AFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVR 130
            |.|..|.||:|...||.|:||.|||:|:||.:|.|.....|||..|:.:|    |:..||...
  Rat    62 ASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGL-- 124

  Fly   131 SPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSST 188
            ..|||.||:||:|.|.:||:||||..||.|....|.::..:       ||.:..   ..:|.|..
  Rat   125 GSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSS---VREAGSMA 186

  Fly   189 VAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVT 243
            ...|| |||...... ::||......|.|   .|.::||.|    |...||      :..||.:.
  Rat   187 GVLIA-GPPGQGQAK-LFVGTPIDGKSEY---FPTLSSRRLMANEEDADMFGFVYQDEFVSSQLK 246

  Fly   244 TGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKE-----YITKLVRICQEDSN 303
            ..:.|.....|.:.|   |||.|.||:|.|:||.|| .:..:||..     :.:|:||:|..|..
  Rat   247 IPSDTLSKFPAFDIY---YVYSFRSEQFVYYLTLQL-DTQLTSPDAAGEHFFTSKIVRLCVNDPK 307

  Fly   304 YYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTN 366
            :|||.|.|:.|   .|.|.::.|||..:|.:|...||:.||::..:||||.||::|:.|  .|..
  Rat   308 FYSYVEFPIGC---EQAGVEYRLVQDAYLSRPGKALAKQLGLAEDEDVLFTVFAQGQKNRVKPPK 369

  Fly   367 NSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGG 430
            .||||:::|::|:.|..:.|:||:.|.|...|.: ::..:.|:.:.|| |.:||||.|.|.||||
  Rat   370 ESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQ-IDDDFCGQDFNQPLGG 433

  Fly   431 ETPITSVPVAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIE----SSSIANEYASFAV 488
            ...|...|  :|..|   ||:|||....|.||||.||..|.::|::::    |...|..|.|...
  Rat   434 TVTIEGTP--LFVDKEDGLTAVAAYDYQGRTVVFAGTRSGRIRKILVDLANPSGRPALAYESVVA 496

  Fly   489 DLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRS 553
            ..|:.|.||:.....:.|:|.|::.:|::|.|..|..|.:|..|||:|||:||||.|.:.||.:.
  Rat   497 QEGNPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQD 561

  Fly   554 NCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFT--TED 614
            .| :.|.:|..:.| ...:|..:| |.|..:..|.:: :.|::.  ::|.|...:.|:|.  ||.
  Rat   562 AC-ERAEEPQRFAS-DLLQCVQLT-VQPRNVSVTMSQ-VPLVLQAWNVPDLSAGVNCSFEDFTET 622

  Fly   615 KALFTNATKKRNGVNCTTPRTDMLPQIEQGK-HHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSS 677
            :::..:..     ::|.:|....:..|.||: .....||.:::: .|....|.||.|::||.|.|
  Rat   623 ESILEDGR-----IHCHSPSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQS 682

  Fly   678 CTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLV 742
            |..||:..|||.||...|.||::.|: |              ::..|     .:|.:.|..::|
  Rat   683 CLACVNGSFPCHWCKYRHVCTNNAAD-C--------------AFLEG-----RVNMSEDCPQIL- 726

  Fly   743 AGGTSKSIKVKVHIIGQFIVQTR-----------FVCQFNIEG---RVTSLNAQLLGDTIYCDSM 793
               .|..|.|.|.::....:..|           :.|.|:|.|   |||:|  :....::.|.:.
  Rat   727 ---PSTHIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGNPARVTAL--RFNSSSLQCQNS 786

  Fly   794 EFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTN 857
            .:.|.... .:|....:|:|.|:..:|||.||...:|:|..:..|||:||....::.||||.:..
  Rat   787 SYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRQSCGLCLKADPRFECGWCVAER 851

  Fly   858 TCEVEEQCNKNKEGKTDWLNR---SEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYS 919
            .|.:...|  ..:....|::.   |..|.:|:|....|:|||.:|||.:||.|.|||..:.|:..
  Rat   852 RCSLRHHC--PADSPASWMHAHHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRL 914

  Fly   920 GVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGD----YRGESKEDYEFVDPKI 980
            ||.:..:.|.|....||..:||||.:.........:..:.|.:.|    ||..|.:.:.||.|..
  Rat   915 GVHVGKVLCSPVESEYISAEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTF 979

  Fly   981 LDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGR-- 1043
            ...:|..||.||||.|.|.|.||||||.:..||... ||.....:|.:..|.|  .||...|.
  Rat   980 YRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSIGGR-PCSFSWRNSREIRCLT--PPGQTPGSAP 1041

  Fly  1044 LKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNI 1107
            :.::.:.......:..:.|..|||:..:.         |: .|.:||..::||||...:::.|.|
  Rat  1042 IVININRAQLSNPEVKYNYTEDPTILRID---------PEWSINSGGTLLTVTGTNLATVREPRI 1097

  Fly  1108 YVVYNGEMYASPCRVQSDTEMECASPVVD--VDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHN 1170
            ...|.|....:.|.|.:||.|.|.:|.:|  ..|.....|||.  |.||:|||   |:.|..:::
  Rat  1098 RAKYGGIERENSCMVYNDTTMVCRAPSIDNPKRSPPELGERPD--EIGFIMDN---VRTLLVLNS 1157

  Fly  1171 NHFELYPNPEYFIFEE-----RVKYFKSEYLTINGRNL---DRACKESDVEVKIGNGFCNITSLS 1227
            :.|..||:|   :.|.     .::...|..|.:.||||   .......:..|.||:..| |.::|
  Rat  1158 SSFLYYPDP---VLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPC-ILTVS 1218

  Fly  1228 RQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV-- 1289
            ..||.|..|       ::.|. :|.||.| ..|:..|:|...|.:::          .:..||
  Rat  1219 ETQLLCEAP-------NLTGQHKVTVRAG-GFEFSPGMLQVYSDSLL----------TLPAIVGI 1265

  Fly  1290 -----ILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDL 1349
                 :|||:.||:|:|||:||.::.|.|:.:|.|||.||.|||.|||||||||||::.:||.||
  Rat  1266 GGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTSDL 1330

  Fly  1350 TSGGIPFLDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESN 1414
            ...||||||||:|||::|||..|||.||: |.......||.|.:||||:..|.|||.||||||:.
  Rat  1331 DGAGIPFLDYRTYAMRVLFPGIEDHPVLK-EMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQ 1394

  Fly  1415 RYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSA 1479
            |.||||:|.|||||||..||.::||.|.:||.||.|||||.:|.|:|||||||||||||||||:.
  Rat  1395 RSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTN 1459

  Fly  1480 WFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYAS 1544
            ||||||||||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::.:.
  Rat  1460 WFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLT---- 1520

  Fly  1545 IIQQPIFCNNLDMLPSHTEN---VSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWR 1606
                 :.|.|    |.| ||   |.||.|:|||:.|||||.|:.:|:.:|.||||:..|:|||||
  Rat  1521 -----LNCVN----PEH-ENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRPKAGDMDLEWR 1575

  Fly  1607 TGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYE 1671
            .|...|:||.|||||:|.:::||:||||.||.|.||:.::|||||:|.||.|..|...:...:||
  Rat  1576 QGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYE 1640

  Fly  1672 TLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLAT 1736
            ::   ..|:|||...|:.:|:.....|:|.:.|||||:||...|:||:|.:|:||||||||||||
  Rat  1641 SM---LRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLAT 1702

  Fly  1737 KGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWV 1801
            |||||||||||||||||||||||||||||||||||||:||..|.|.|.:|.||||||.|||||||
  Rat  1703 KGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDSDVRHTWKSNCLPLRFWV 1767

  Fly  1802 NLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRY 1866
            |:||||.|||||||::|.|:||||||||||||||||:|:|||||||:|||||||||.|:.||:||
  Rat  1768 NVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERY 1832

  Fly  1867 YRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRL 1931
            |.||..|..||||||:|.|||:||||.::||:..||||:|:|..||.:::.|.||:||.:::|||
  Rat  1833 YADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYIAKYKDEILVALEKDEQARRQRL 1897

  Fly  1932 AFKLEQVHNIMS 1943
            ..|||||.:.|:
  Rat  1898 RSKLEQVVDTMA 1909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	172/480 (36%)
		PSI	522..574	CDD:279745	20/51 (39%)
		PSI	671..>699	CDD:279745	14/27 (52%)
		PSI	830..883	CDD:279745	14/55 (25%)
		IPT_plexin_repeat1	885..977	CDD:238585	32/95 (34%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/86 (31%)
		IPT	1078..1177	CDD:301692	33/101 (33%)
		IPT_PCSR	1196..>1255	CDD:238337	19/62 (31%)
		Plexin_cytopl	1353..1916	CDD:285529	359/565 (64%)
Plxna1	XP_002729444.2	Sema_plexin_A1	54..529	CDD:200532	174/486 (36%)
		PSI	530..>572	CDD:279745	19/42 (45%)
		PSI	676..723	CDD:279745	20/66 (30%)
		PSI	827..878	CDD:279745	13/52 (25%)
		IPT_plexin_repeat1	880..976	CDD:238585	32/95 (34%)
		IPT_plexin_repeat2	977..1062	CDD:238584	28/87 (32%)
		IPT_plexin_repeat3	1064..1164	CDD:238586	35/113 (31%)
		TIG	1166..1250	CDD:280079	25/95 (26%)
		Plexin_cytopl	1334..1882	CDD:285529	359/565 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340902
Domainoid	1	1.000	710	1.000	Domainoid score	I112
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I118
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm46024
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760