DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexA and plxna4

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_001004495.1 Gene:plxna4 / 325938 ZFINID:ZDB-GENE-030131-4663 Length:1903 Species:Danio rerio


Alignment Length:1946 Identity:810/1946 - (41%)
Similarity:1133/1946 - (58%) Gaps:173/1946 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 NHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDC--PLNAVRSPTD 134
            |||.||...|.|::|.|||:|:|||.|::..:.:|||..|:..|    .:..|  ||..    |:
Zfish    54 NHLAVDHRNGNVYLGAVNRIYKLSPGLDIQVSHQTGPDEDNRNCYPPRIVQPCSEPLTL----TN 114

  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSSTVAFI 192
            |.||:||:|...:||:|||||:||.|.:..|.::..:       ||.:..   .|::.|.....:
Zfish   115 NVNKMLLMDYRENRLLACGSLYQGICKLLRLDDLFKLGEPFHKKEHYLSG---VNESGSVFGVIV 176

  Fly   193 APGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVTTGTR 247
            :.|...   .:.::|.........|   .|.::||.|    |:..||      :..:|.:...:.
Zfish   177 SYGDAS---PDKLFVATAVDGRPEY---FPTISSRKLTRNSEEDGMFAYVFHDEFVASMIKIPSD 235

  Fly   248 TFINSYARETYFVNYVYGFSSERFSYFLTTQLK--------HSHHSSPKEYITKLVRICQEDSNY 304
            ||.   ....:.:.|||||||..|.||||.|.:        .|.....:.|.:||||:|::|:.:
Zfish   236 TFT---VVPDFDIYYVYGFSSGNFVYFLTLQPEMGGGPTTGSSSAGREQVYTSKLVRLCKDDTAF 297

  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTP---TN 366
            .||.|:|:.|:   :||.::.|:||.:|.|..:.||:||||...||:|:||||||:...|   :.
Zfish   298 NSYVEVPLGCV---KGGVEYRLLQAAYLSKAGTILARSLGIGPDDDILYAVFSKGQKRRPKESSQ 359

  Fly   367 NSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGE 431
            .||||:::||.|..:....::||:.|.|...|.::........:.|.||.::|||||:|:|||..
Zfish   360 ESALCVFTLKEINERIKDRLQSCYKGEGTLDLAWLKVKDISCSSALLTIDDNFCGLDMNAPLGVS 424

  Fly   432 TPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSI-ANEYASFAVDLGSEI 494
            ..:..:|: :....|:|||.|.....:::.||||..|.|||:.::..:. |.:|.:..|.....|
Zfish   425 EMVRGIPLFSESKDKMTSVIAYVYKNHSLAFVGTRGGRLKKIRVDGPTYGALQYETIQVVDNGPI 489

  Fly   495 NRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDA 559
            .|||.|.:...::||||::::::|.|..|..|.:|.:|||:.||:||||.|.:.|:.:..| :.:
Zfish   490 LRDMAFSSDQHFLYVMSESQLTRVPVEACEQYSSCNECLGSGDPHCGWCVLHSMCTRKEKC-ERS 553

  Fly   560 NDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFTTEDKALFTNAT 622
            ::|..:.| ...:|..: ||.|:.:. .:..::.|:::  ::|:|...:.|.|  ||.|.. :..
Zfish   554 SEPRRFAS-NIKQCVRL-SVHPNNIS-VSQYSVMLVLEAHNVPELSAGVNCTF--EDLAEM-DGL 612

  Fly   623 KKRNGVNCTTPRTDMLPQI--EQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSE 685
            .:.|.:.|::|....:|:|  :||.|............|....:|.|.|::||.|.||..||.|.
Zfish   613 VEGNRITCSSPAEKEVPRIIVDQGDHQIVQLYLKSKETGLAFANTSFVFYNCSVHKSCLSCVGSP 677

  Fly   686 FPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGGT 746
            :.|.||...|.||||.: :|              |::.|    |..||.:.   ....:||....
Zfish   678 YQCHWCKYRHTCTHDPS-SC--------------SFQEGRVKQPEECPQLL---PADRILVPVNV 724

  Fly   747 SKSIKVKVHIIGQ-FIVQTRFVCQFNIEG---RVTSLNAQLLGDTIYCDSMEFQYTS-RSPNLTA 806
            .|.|.::...:.| ...|..:.|...|:|   ||.:|  :....::.|.:..:.|.. ...:|..
Zfish   725 VKPITLRAKNLPQPQSGQRGYECVLTIQGVEQRVPAL--RFNSSSVQCQNTSYMYDGMEMSSLPV 787

  Fly   807 TFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEG 871
            ...|||.|...:|||....|.:|:|....:|||:||.....:.|.||...|.|.:::.|:   ..
Zfish   788 DLTVIWNGDFSIDNPAQNKVHLYKCDARRESCGLCLKADPLFGCVWCKGENRCSLKQHCS---YP 849

  Fly   872 KTDWLNRSEI---CPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQ 933
            ::.||..:.|   |.:|.|....|..||.||||.:||||.|||..:::|...|::|.:.|.|.|:
Zfish   850 QSMWLEHNGINSKCTHPRITKITPLRGPREGGTLVTIRGENLGLEFSEIKDHVKVADVECTPVPE 914

  Fly   934 FYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGE----SKEDYEFVDPKILDFNPKFGPTSGGT 994
            .||..:||||.: ...|:....|.:.|.:|:.|.|    |.:.|.||.|::|...|..||.||||
Zfish   915 GYIPAEQIVCEM-GKAERSQFAGNVQVCVGECRPEFMAKSSKYYYFVIPQLLSLKPSRGPISGGT 978

  Fly   995 EIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMS---FDNGPREFN 1056
            .::|||.:|:|||.:.....|. .|...........||:.||   ::|...:|   :.:......
Zfish   979 IVNITGGNLDAGSNVSIMFKDQ-KCTYQRRGGQWITCRSHAS---MQGYGNVSVSVYVDKAHIHK 1039

  Fly  1057 DYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCR 1121
            |..|:||.|||:.        :::....|.:|...::|:||....|..|.|...|......:.|:
Zfish  1040 DLKFEYVEDPTIT--------KLEPEWSIFSGNTPLTVSGTNLDIIHTPLIRAKYKNLETINICQ 1096

  Fly  1122 VQSDTEMECASPVV--DVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIF 1184
            |.|.|.|:|.:|.:  .:..|....|||.  |:||::||   ||::..::|.:|..||||   :|
Zfish  1097 VLSPTTMQCMAPELPYSISKHKDVPERPD--EFGFILDN---VQSVLALNNTNFVYYPNP---VF 1153

  Fly  1185 E----ERVKYFK-SEYLTINGRNL----DRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEAT 1240
            |    ..|:..| ...:.:.|||.    .....:.:..|.||:..|.:| :|..||.|..|:...
Zfish  1154 EPLSVSGVQELKPGSPIILKGRNFLPPTPGGNGKLNYTVLIGDKPCALT-VSDTQLLCESPNLTG 1217

  Fly  1241 ATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKK 1305
            ..|      |:.|:| .:|:..|::...|.:.:   ....:.::.....:|:...|.:|:|||:|
Zfish  1218 RHK------VLARVG-GIEFSPGVVHITSDSPL---SSTAVISIAGAGGLLIFFIVIVLIAYKRK 1272

  Fly  1306 SSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPN 1370
            |.||...|:.:|.|||.||.|||.|||||||||||::.:||.||...||||||||:|.|::|||.
Zfish  1273 SRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPG 1337

  Fly  1371 HEDHIVLQ-WERPELLRK--EKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVT 1432
            .|:|.||: .|.|...::  ||||::|||||.||.|||.|||||||.|.||||:|.|||||||..
Zfish  1338 IEEHPVLRDLEVPGYRQEQVEKGLKLFGQLINNKVFLLSFIRTLESQRGFSMRDRGNVASLIMTV 1402

  Fly  1433 LQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPL 1497
            |||||||.||:||.||.|||:|.:|.|:|||||||||||||||||:.||||||||||||||||||
Zfish  1403 LQSKLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPL 1467

  Fly  1498 YMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHT 1562
            :.||.|:|.|::|||:|:.|.||||||||:|||||.||::.:.|..             |.|.:.
Zfish  1468 FSLFCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIDYKTLVVNC-------------MHPDNE 1519

  Fly  1563 EN--VSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTE 1625
            ::  |.||||:|||:.|||||.|:.||:|:|.|.||:..|:|||||.|...||||.|||||:|.|
Zfish  1520 KSPEVQVKVLNCDTVSQVKEKILDAIYKNVPYSHRPKASDMDLEWRQGRVVRVILQDEDVTTKIE 1584

  Fly  1626 SEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKS-HKYETLNISKYTSSSPTFSRAG 1689
            ::||:||.|.||.|.|.|.::|||||.:.||....|..:..| .|||  |:.||| .||...|:.
Zfish  1585 ADWKRLNMLSHYQVTDNAVVALVPKQVTAYNSVNNSTVSRTSASKYE--NMIKYT-GSPDSLRSR 1646

  Fly  1690 SPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFST 1754
            :|:.....|:|::.|||||:|:...||||:|.:|:||||||||||||||||||||||||||||||
Zfish  1647 TPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFST 1711

  Fly  1755 AHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIV 1819
            |||||||||||||||||||:||..|.|.||.|.||||||.||||||||:||||.||||||||:|.
Zfish  1712 AHRGSALPLAIKYMFDFLDEQADKHNIHDPHVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKSSIT 1776

  Fly  1820 DSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAM 1884
            |:||||||||||||||||:|||||||||:|||||||||.|:.||:|||.||..|..||||||||.
Zfish  1777 DACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYSDISKMPAISDQDMNAY 1841

  Fly  1885 LAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMSSE 1945
            |||:||:|..||||..:|.|:|:|..||.|::...||:|:.::|||||:|||||...||.|
Zfish  1842 LAEQSRMHMNEFNTMSSLSEIYSYIGKYTEEIVSALEQDDGARKQRLAYKLEQVVAFMSLE 1902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 159/479 (33%)
PSI 522..574 CDD:279745 17/51 (33%)
PSI 671..>699 CDD:279745 13/27 (48%)
PSI 830..883 CDD:279745 15/55 (27%)
IPT_plexin_repeat1 885..977 CDD:238585 37/95 (39%)
IPT_plexin_repeat2 978..1063 CDD:238584 26/87 (30%)
IPT 1078..1177 CDD:301692 29/100 (29%)
IPT_PCSR 1196..>1255 CDD:238337 16/62 (26%)
Plexin_cytopl 1353..1916 CDD:285529 370/568 (65%)
plxna4NP_001004495.1 Sema 41..519 CDD:301699 160/483 (33%)
PSI 518..567 CDD:279745 17/50 (34%)
PSI 663..710 CDD:214655 20/61 (33%)
PSI 814..864 CDD:279745 14/52 (27%)
IPT_plexin_repeat1 866..960 CDD:238585 36/94 (38%)
IPT 962..1047 CDD:301692 27/88 (31%)
IPT_plexin_repeat3 1049..1149 CDD:238586 31/112 (28%)
TIG 1167..1238 CDD:280079 19/78 (24%)
Plexin_cytopl 1320..1873 CDD:285529 370/568 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580770
Domainoid 1 1.000 710 1.000 Domainoid score I116
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1364 1.000 Inparanoid score I128
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 1 1.000 - - otm24994
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - LDO PTHR22625
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3977
SonicParanoid 1 1.000 - - X591
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.790

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