DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexA and Plxnb1

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_001101658.2 Gene:Plxnb1 / 316009 RGDID:1310564 Length:2121 Species:Rattus norvegicus


Alignment Length:2230 Identity:713/2230 - (31%)
Similarity:1048/2230 - (46%) Gaps:505/2230 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 AAF---DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SIL--DCPL 126
            |||   .|.|.||..|..||.::||..|.|:||||.|:|...|.|||.|||.:|  .::  :|| 
  Rat    26 AAFTANGTHLQHLARDPTTGTLYVGATNFLFQLSPGLQLEAVVSTGPVNDSRDCLPPVIPDECP- 89

  Fly   127 NAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVS--IIEHEVP---DAVVANDANS 186
              ...||:|.|::||:  :...|:.|||:.||.|.:|:|..:.  ::..|.|   ..|.|||...
  Rat    90 --QAQPTNNPNQLLLV--SPEALVVCGSVHQGICELRSLGQIRQLLLRPERPGDTQYVAANDPAV 150

  Fly   187 STVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL-----------EKTKMFQIASS 240
            |||..:|.|....|   :::||..||:.. ....||.:.:|:|           |:|.  ::|..
  Rat   151 STVGLVAQGLAGEP---LLFVGRGYTSRG-VGGGIPPITTRALRPPDPQAAFSYEETA--KLAVG 209

  Fly   241 AVTTGTRTFINSYARET--YFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSN 303
            .::..:..|::::.|.|  ||:             ||...||....:. :.|::   |:|.:|.:
  Rat   210 RLSEYSHHFVSAFVRGTSAYFL-------------FLRRDLKAPSRAF-RAYVS---RVCLQDQH 257

  Fly   304 YYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSK---------- 358
            ||||.|:|:.|    ||| ::.|:||..:. .|.:.|:.       ::|||.||.          
  Rat   258 YYSYVELPLAC----QGG-RYGLIQAAAVA-TSKEAARG-------EILFAAFSSVAPPTVDWPL 309

  Fly   359 GEGNTPTNNSALCIYSLKSIRRKFMQNIKSCF-------NGSGMRGL--DFISPSMPCVLTKLQT 414
            ......:..|.||.:.|..:.:.......:|:       ||:.:..:  |.:|   .|....:.|
  Rat   310 SASTGASGTSVLCAFPLDEVDQLANDTRDACYTREGRAENGTKVADIAYDVLS---DCAQLPVDT 371

  Fly   415 IGEDFCGLD-VNSPLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESS 477
            .....||.| ..||:....|:.:.|: .:...:||:||.|...|:|:.|:|.|.|.|.:|.:...
  Rat   372 PDAFPCGSDHTPSPMVSCVPLEATPILELPGVQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPG 436

  Fly   478 SIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGW 542
            ..|..|:..::..||.:|||:.||....::||.::|.:.||.|..|:.:..|..||..|||||||
  Rat   437 RSAAPYSKQSIQPGSAVNRDLTFDGTFEHLYVATQTTLVKVPVAPCAQHLDCDSCLAHRDPYCGW 501

  Fly   543 CSLENKCSPRSNCQDDANDPLYWV-SYKTG-KCTTITSVVPHQLQRTTARTLELIIDHLPQL--K 603
            |.|..:||.||.| ..|..|..|: |:::. .|..:.:|.|..:.|...|.:.|.:..||.|  :
  Rat   502 CVLLGRCSRRSEC-SRAQGPEQWLWSFQSELGCLRVVAVSPANISRGERREVFLSVPGLPSLWPE 565

  Fly   604 ENLICAF-TTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLV-STD 666
            |:..|.| ..:..||.|:     :||.|.:|.....|.:::|..|.:  ::|..|.|..:: :|.
  Rat   566 ESYFCYFGDQQSPALLTS-----SGVMCPSPDPSEAPVLQRGADHIS--VNVELRFGAVVIANTS 623

  Fly   667 FTFFDCST------HSSCTRCVSSEFPCDWCVEAHRCTHDT------------------------ 701
            .:|:||..      .:.|..||||.:.|:|||....|||..                        
  Rat   624 LSFYDCMAVTEFFPSAPCRACVSSRWGCNWCVWQQLCTHKASCDSGPMVASQQSPLLPLIPPARD 688

  Fly   702 --------------------------AENCRNDIL------------------------------ 710
                                      |.:..:|:|                              
  Rat   689 VLTPFPLTVPRATATPTPNTFPAEPRAPSIASDVLPGAKPSRLSLWGPWAGPGPILSPTSTESPL 753

  Fly   711 ----------------VTGVSRIGP---------SY------------RSGPGFCPTI------- 731
                            |...:.:||         ||            ..||...|::       
  Rat   754 HEKPLPPEPPTTPGTTVPAPADLGPLTTPEDLLASYPFPSDAAAVSPTEPGPETLPSMVALDQPP 818

  Fly   732 ---------NATGD-----------GSEVLVA----GGTSK------------------------ 748
                     .|||.           |.|:|.|    ||.:.                        
  Rat   819 GTAPATLFPGATGSMKPVLDWLTKGGGELLEAEEWMGGDTPAFSTSTLLSGDGDSAEHEGPSAPL 883

  Fly   749 ------------------------------------SIKVKVHIIGQFIVQTRFV---------- 767
                                                |:.:.||:..:..::.|.:          
  Rat   884 ILLSSLDYQYDTPGLWELGEVNQRVSSCPCVENVQGSLLIPVHVKREVQLRGRNLWLFQDGPRSS 948

  Fly   768 -CQFNIEGRVTSLNAQL----LGDT---IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNI 824
             |...:||...::.||:    ..||   |.|...:|.|.:..|.|.....:.|.|...:|:...:
  Rat   949 ECVLVLEGLEVAVEAQVECEPPPDTWCHIKCQQHQFSYEASKPELQVGLFLRWAGGLRVDSADGL 1013

  Fly   825 HVVIYRCREMADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIH 888
            |||:|.|......|..|.....:|:|.||...: .|...|.||:.:...|.       ||.|.||
  Rat  1014 HVVLYDCSVGHGDCSRCQTAMPQYDCVWCEGEHPRCVAREACNEAETVATQ-------CPAPLIH 1071

  Fly   889 TFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY 953
            :.:|.|||.:|||.:||||.|||::..|:...||:||:.|......|..:..:||...|.||:: 
  Rat  1072 SVEPLTGPIDGGTRVTIRGSNLGQHVQDVLGMVRVAGVPCAVDVGEYDVSSSLVCITGSSGEEV- 1135

  Fly   954 RNGKIVVQI-GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAG--SRIQASIND 1015
             .|.:.|:: |...|.|:..:.:.|||:|...|..||.:|||.:.:.|..|..|  ..|:..:.|
  Rat  1136 -TGAVAVEVPGRGHGVSEFSFAYQDPKVLSIFPVHGPRAGGTHLTLHGSKLLTGRLEDIRVVVGD 1199

  Fly  1016 HLPCK-ILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQI 1079
            . ||. :|...|.|..|.||.:|...|..:.:.|....|......|||..||.:  .|.||:   
  Rat  1200 Q-PCHLLLEQQSEQLHCETSPNPVPAELPVMVWFGATERRLQHSQFKYTADPNI--TSVGPA--- 1258

  Fly  1080 KVPKGIPAGGIRISVTGTQFTSIQNPNIYVV------YNG-----------EMYASPCRVQSDTE 1127
               |...:||..|.|.|.....:|.|.|.|.      .:|           |....||.|.|   
  Rat  1259 ---KSFFSGGREIWVRGQNLDVVQMPRIRVTVIPRVPQHGQGLGQKHHVVPEKIEEPCLVNS--- 1317

  Fly  1128 MECASPVVDVDSHVIEAERPIL--------LEYGFLMDNVLRVQNLSKVHNNHFE---LYPNPEY 1181
                       ||:|....|.|        ::..|::||::            |:   |.|.|..
  Rat  1318 -----------SHLIMCRSPALPGPPQDPWVQVEFILDNMV------------FDFATLSPTPFS 1359

  Fly  1182 FIFEERVKYFKSE------------YLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCR 1234
            :..:..::....|            ..::.|.|||.|..:.:|...||:|.|.:.:|:|..|.|.
  Rat  1360 YEADPTLRSLNPEDPTTPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCE 1424

  Fly  1235 PPSE---------ATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGEN-VIFAVIAT-- 1287
            ||.|         ..|..::  ||..|::| :|.:.:|.:.|:        ||: |.|.|.|.  
  Rat  1425 PPVEQPLPHHHALREAPDAL--PEFTVQMG-NLRFSLGHVQYD--------GESPVAFPVAAQVG 1478

  Fly  1288 ----IVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGD 1348
                :.:|.|..:.:::.|::||.::.|..:.:|.|::.||..|...||:.|.:|.|||||||.|
  Rat  1479 LGVGVSLLALGVIVIVLIYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSD 1543

  Fly  1349 LTSGGIPFLDYRSYAMKILFPNHE------DHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLF 1407
            |...|||||||:.||.::.||.|:      |..|....||.:   |:||.....|:.:|.||..|
  Rat  1544 LLGSGIPFLDYKVYAERVFFPGHQESPLHRDLGVPDSRRPTV---EQGLGQLSNLLNSKLFLTKF 1605

  Fly  1408 IRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESV 1472
            |.||||.|.||.|:|..||||:.|.|..||||.||||:|||.||:.:|:  ..:|||:|||||:|
  Rat  1606 IHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQCV--AKNPKLMLRRTETV 1668

  Fly  1473 AEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFR 1537
            .||:|:.|.:..||.|:::..|||||||||.:|.||||||||:.|.:|:|:|::.:|:|:.:::|
  Rat  1669 VEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYR 1733

  Fly  1538 PMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLD 1602
            |:.:.|.:...|        .....::|.|||||||||.|.|||.|:.:|:.:|.:|||....||
  Rat  1734 PLTLNALLAVGP--------GAGEAQSVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDSRTLD 1790

  Fly  1603 LEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKS 1667
            :|||:|..|.:||.||||||:.|..|::|||||||.|||||.::|||..:.    .||.:..:  
  Rat  1791 VEWRSGVAGHLILSDEDVTSELEGLWRRLNTLQHYKVPDGATVALVPCLTK----HILRENQD-- 1849

  Fly  1668 HKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDS--------DMQKEGERVN-K 1723
                      |.....|      |:..|:.|.|:|.|||||..|.        ...:.|||.. |
  Rat  1850 ----------YVPGERT------PMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAK 1898

  Fly  1724 LVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVH 1788
            .:.||||||||:.||||||||||||:.|.||:.   .:|||:||.||.||:|||.|||:|.:.:|
  Rat  1899 AIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFDLLDEQAQQHGISDQDTIH 1960

  Fly  1789 TWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYA 1853
            .||:||||||||:|:||||.||||:..|:.:|:.|.|:||||||:|:.:||:||:|||.:|||||
  Rat  1961 IWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYA 2025

  Fly  1854 KDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTV 1918
            :|||.|::.|:|||.|||...|.|||:||::|||.||..:.:.....||||||.|..||.:|:..
  Rat  2026 RDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSRNCSADLGARVALHELYKYINKYYDQIIT 2090

  Fly  1919 TLEEDEFSQKQRLAFKLEQV 1938
            .||||..:||.:|.::|:|:
  Rat  2091 ALEEDGTAQKMQLGYRLQQI 2110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 142/487 (29%)
PSI 522..574 CDD:279745 22/53 (42%)
PSI 671..>699 CDD:279745 12/33 (36%)
PSI 830..883 CDD:279745 12/53 (23%)
IPT_plexin_repeat1 885..977 CDD:238585 34/92 (37%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/87 (32%)
IPT 1078..1177 CDD:301692 26/126 (21%)
IPT_PCSR 1196..>1255 CDD:238337 21/67 (31%)
Plexin_cytopl 1353..1916 CDD:285529 282/577 (49%)
Plxnb1NP_001101658.2 Sema 28..480 CDD:417757 144/495 (29%)
PSI 481..533 CDD:396154 22/52 (42%)
TIG_plexin 541..627 CDD:407808 24/92 (26%)
PSI 641..677 CDD:214655 12/35 (34%)
PHA03247 <669..824 CDD:223021 11/154 (7%)
TIG_2 919..1018 CDD:407859 23/98 (23%)
PSI 1019..1066 CDD:214655 12/53 (23%)
IPT_plexin_repeat1 1068..1159 CDD:238585 34/92 (37%)
IPT 1160..1247 CDD:417750 28/87 (32%)
IPT 1250..1362 CDD:417750 32/145 (22%)
Plexin_cytopl 1548..2088 CDD:400574 282/577 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.820

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