DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Plxna2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001099458.2	Gene:	Plxna2 / 289392	RGDID:	1305325	Length:	1894	Species:	Rattus norvegicus

Alignment Length:	1970	Identity:	815/1970 - (41%)
Similarity:	1153/1970 - (58%)	Gaps:	219/1970 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTD 134
            |...|||.|...||.|:||.:||:|:|:.:|.:....||||:.|:..|  .::..|.:.|.:.|:
  Rat    47 DWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTN 111

  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD---------AVVAND 183
            |.||:|:||.:.:||:|||||:||.|.:..|.::.|:       ||.:..         .:|.::
  Rat   112 NVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSE 176

  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAV 242
            .....                :::|........|   .|.::||.|    |.:.|  :::.|..|
  Rat   177 GEDGK----------------LFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFV 222

  Fly   243 TTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLKHSHHSSPKE----------YITKLVR 296
            ::..:...::.|..::| :.|:|||:|..|.||||.|     ..:|:.          |.:::||
  Rat   223 SSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQ-----PETPEGMAINSAGDLFYTSRIVR 282

  Fly   297 ICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG 361
            :|::|..::||..:|..|   .:.|.::.|:||.:|.||...|||:..||.::|||||:||||:.
  Rat   283 LCKDDPKFHSYVSLPFGC---TRAGVEYRLLQAAYLAKPGEALAQAFNISSEEDVLFAIFSKGQK 344

  Fly   362 --NTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGL 422
              :.|.::||||.:.:::|..:..:.::||::|.|...|:: :...:.|  ||... |.::||||
  Rat   345 QYHHPPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQC--TKAPVPIDDNFCGL 407

  Fly   423 DVNSPLGGETPITSVPVAMFNT---KLTSVAATSTSGYTVVFVGTSDGFLKKVVIES---SSIAN 481
            |:|.||||.||:..  :.::.|   :|||||:...:||:||||||..|.|||:..:.   ..:..
  Rat   408 DINQPLGGSTPVEG--LTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQY 470

  Fly   482 EYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLE 546
            |..|...| ||.|.|||.|....||:||||:.:|::|.|..|..|.|||:||.:.||:||||:|.
  Rat   471 EMVSVFKD-GSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALH 534

  Fly   547 NKCSPRSNCQD--DANDPLYWVSYKTGKCTTITSVVPHQLQRTT-ARTLELIIDHLPQLKENLIC 608
            |.||.|..||.  :||.    .:....:|.:: .|.|:.:..:. :|.|.|:::..|.|.|.:.|
  Rat   535 NMCSRRDKCQRAWEANR----FAASISQCMSL-EVHPNSISVSDHSRLLSLVVNDAPNLSEGIAC 594

  Fly   609 AFTTEDKALFTNATKKRNGVN-----CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVSTDF 667
            |        |.|.|:....|:     |.:|....:|.|...:..|..:|.:|:: .|...|||:|
  Rat   595 A--------FGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEF 651

  Fly   668 TFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFC 728
            .|::||.|..|..||:|.|.|.||...:.||||.. .|              |::.|    ...|
  Rat   652 KFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TC--------------SFQEGRINVSEDC 701

  Fly   729 PTINATGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCD 791
            |.:..|   .|:|:..|..|.|.:|...:.| ...|..:.|..||:|.|..:.| :....::.|.
  Rat   702 PQLVPT---EEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAVHRVPALRFNSSSVQCQ 763

  Fly   792 SMEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSS 855
            :..:||.... .||...|||:|.|:..:|||.::.|.:|:|....:|||:||....|:.|||||.
  Rat   764 NSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSG 828

  Fly   856 TNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSG 920
            ...|.:.:.|........||.:.:..|.||:|......:||.||||.:||.|:|||.::::|...
  Rat   829 ERRCTLRQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHH 893

  Fly   921 VRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY--RNGKIVVQIGDYRGE----SKEDYEFVDPK 979
            |::||:.|.|.|..||..:||||.:   |..:.  .:|.:.:.||:.:.|    |.:.|.||:|.
  Rat   894 VQVAGVPCTPIPGEYIIAEQIVCEM---GHALMGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPS 955

  Fly   980 ILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAIC-RTSASPGIIEGR 1043
            :|..:|..||.||||.:.|||.:|.|||.:...:.:. .|:......::.:| ...:|.|:....
  Rat   956 VLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQ-TCEFYGRSMNEIVCVSPPSSNGLGPVP 1019

  Fly  1044 LKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNI 1107
            :.:|.|.. |..:...|:|:.||.|:.:.         |: .|.:|...:::||.....||.|.|
  Rat  1020 VSVSVDRA-RVDSSLQFEYIDDPRVQRIE---------PEWSITSGHTPLTITGFNLDVIQEPRI 1074

  Fly  1108 YVVYNGEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSKVHN 1170
            .|.:||:...:.|.|.:.|.:.|.:|.:..|..  :...|||.  |:|||.:|   ||:|...::
  Rat  1075 RVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPD--EFGFLFNN---VQSLLIYND 1134

  Fly  1171 NHFELYPNPEY------FIFEERVKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNI 1223
            ..|..||||.:      .|.:::    ....:.:.|:||   |..:      :..|.||...|.:
  Rat  1135 TKFIYYPNPTFELLSPTGILDQK----PGSPIILKGKNL---CPPASGGAKLNYTVMIGETPCTV 1192

  Fly  1224 TSLSRQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIAT 1287
            | :|..||.|.||       ::.|. :|:|.:| .:.:..|.:|..|.:::.   ...|.::.|.
  Rat  1193 T-VSETQLLCEPP-------NLTGQHKVMVHVG-GMVFSPGSVSVISDSLLT---LPAIISIAAG 1245

  Fly  1288 IVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSG 1352
            ..:||:|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...
  Rat  1246 GSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRS 1310

  Fly  1353 GIPFLDYRSYAMKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRT 1410
            |||:||||:|||::|||..|||.||:    ||       ...||.|::|.|||.||.|||.||||
  Rat  1311 GIPYLDYRTYAMRVLFPGIEDHPVLR----ELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRT 1371

  Fly  1411 LESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEK 1475
            ||..|.||||:|.|||||||..||.:|||.||:||.||.|||:|.:|.|:|||||||||||||||
  Rat  1372 LELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEK 1436

  Fly  1476 MLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMN 1540
            ||:.||.|||:|||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.|:
  Rat  1437 MLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIE----- 1496

  Fly  1541 VYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEW 1605
             |.::|   :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:||||
  Rat  1497 -YKTLI---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEW 1555

  Fly  1606 RTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKY 1670
            |.|...||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|...
  Rat  1556 RQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASASI 1613

  Fly  1671 ETLNISKYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYL 1730
            ...:||:|.||     ||...|:..|:.....|:|::.|||||:||...||||:|.:|:||||||
  Rat  1614 SRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYL 1678

  Fly  1731 TRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSL 1795
            ||||||||||||||||||||:|||.||||||||||||||||||:||..|.|.|.:|.||||||.|
  Rat  1679 TRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCL 1743

  Fly  1796 PLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYR 1860
            |||||||:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.|:
  Rat  1744 PLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYK 1808

  Fly  1861 KWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEF 1925
            .||:|||.||..:..||||||||.|||:||||.||||...||:|:|:|..||:|:|...||:||.
  Rat  1809 NWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQDEQ 1873

  Fly  1926 SQKQRLAFKLEQVHNIMSSE 1945
            :::||||:|:|.:.|.||.|
  Rat  1874 ARRQRLAYKVEHLINAMSIE 1893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	161/489 (33%)
		PSI	522..574	CDD:279745	22/53 (42%)
		PSI	671..>699	CDD:279745	12/27 (44%)
		PSI	830..883	CDD:279745	16/52 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	978..1063	CDD:238584	24/85 (28%)
		IPT	1078..1177	CDD:301692	30/101 (30%)
		IPT_PCSR	1196..>1255	CDD:238337	18/65 (28%)
		Plexin_cytopl	1353..1916	CDD:285529	361/574 (63%)
Plxna2	NP_001099458.2	Sema_plexin_A2	38..552	CDD:200533	185/540 (34%)
		PSI	655..702	CDD:279745	18/61 (30%)
		PSI	806..855	CDD:279745	15/48 (31%)
		IPT_plexin_repeat1	858..953	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	954..1037	CDD:238584	24/84 (29%)
		IPT_plexin_repeat3	1041..1141	CDD:238586	32/113 (28%)
		TIG	1143..1227	CDD:280079	22/99 (22%)
		Plexin_cytopl	1311..1864	CDD:285529	361/574 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I112
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I118
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm46024
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830