DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plx-1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001294554.1	Gene:	plx-1 / 246019	WormBaseID:	WBGene00004047	Length:	1956	Species:	Caenorhabditis elegans

Alignment Length:	1979	Identity:	771/1979 - (38%)
Similarity:	1133/1979 - (57%)	Gaps:	172/1979 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NVAAFDTKL-----NH--------LLVDTITGRVFVGGVNRLYQL-SPDLELSETVKTGPQNDSV 117
            ||.:.|..|     :|        :.:|..|.|||||.||.||.| |.||.:...|:||||:||.
Worm    22 NVYSIDDNLVFKNPSHDGHEVFEKMAIDPSTTRVFVGAVNSLYDLTSADLTVRRHVQTGPQDDSP 86

  Fly   118 EC----SILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDA 178
            .|    :..:|.....|  |:::.|.|.:...:|:||.|.:|:||.|.:|||.|:|.:..|..:.
Worm    87 LCRDARNREECRHQLSR--TNSHTKALSVYDKSSKLIECSNLYQGRCRLRNLHNISEVISEAIEP 149

  Fly   179 VVANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVT 243
            .|:||.:||.|.|:..||.......|:|||.|..:....|.   :|:|..|...|.|::....:.
Worm   150 RVSNDTSSSVVIFVGSGPANLSSEPVLYVGATIGSGDHDRM---SVSSLFLRPQKAFEVVFPGLY 211

  Fly   244 TGTRTFINSYAR--ETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYS 306
            .||...::..:|  ..|.::|:.||.|..::||:|.|..:....|..:  ::|||:|..|.|::|
Worm   212 GGTHVSLDYRSRGYYKYQIDYINGFESGDYAYFVTRQRVNIADDSSIQ--SRLVRVCTGDKNFHS 274

  Fly   307 YTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNT-----PTN 366
            |||:|:||   .|.|.:|||||..::.:...:||:||.||:.|.||:.||.:|:.|:     ||.
Worm   275 YTEVPLEC---TQNGVEFNLVQDVYVTRAGYELAKSLDISVSDPVLYGVFWEGDKNSYRSQEPTG 336

  Fly   367 NSALCIYSLKSIRRKFMQNIKSCFNG-SGM-RGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLG 429
            .||:|:::::.|...|.|||..|:.| ||: :.|.:.|.:..|..|.|...|.. ||.||||.:|
Worm   337 KSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSSNDDCRFTTLPWEGIK-CGKDVNSKIG 400

  Fly   430 GETPI-TSVPVAMFNTK--LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLG 491
            |:||| ||....|.::.  ||::|..:|...||.||||..|.|.|::|||...|.:||:..:...
Worm   401 GDTPISTSATYVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKILIESKRSAEKYATEMLTDN 465

  Fly   492 SEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKT-CGDCLGARDPYCGWCSLENKCSPRSNC 555
            ..|..||:|.....::|:::.:||.|:....|....| |..||.:||||||||...|.|:...:|
Worm   466 EPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESC 530

  Fly   556 QDDA-NDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQLK-ENLIC--AFTTEDKA 616
            :.:. :....|:.::..||..|.||.|.|:|..||..|.:.|::|...| ..:.|  .|:|.| |
Worm   531 EREVPHTSRGWLDFQNSKCPRIRSVKPDQIQINTADYLNVTIENLQAPKGRRMQCLFQFSTGD-A 594

  Fly   617 LFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGP-DLVSTDFTFFDCSTHSSCTR 680
            :.::.......:.|.||..:.||:|...::|..|||.|.:.... .|.:|:|:|:||:.::||:.
Worm   595 VVSDPMPFDGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNRYTSCST 659

  Fly   681 CVSSEFPCDWCVEAHRCTHD--TAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVA 743
            |.:|:||||||:|::.|...  |.:.||...:|.|::|.|.|.|.||..||.|.|  ..|::.||
Worm   660 CSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPHIVA--PVSKMSVA 722

  Fly   744 GGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVT--SLNAQLLGDTIYCDSMEFQ-YTSR---SP 802
            .|..::|.|||..:....:.. |.|:|.. |.||  .:..:...|||.||.|.|: |.:.   |.
Worm   723 TGERRNISVKVENVDATFMGD-FKCEFKY-GTVTHEKIAMRTSDDTITCDEMLFEPYGTSLLGSG 785

  Fly   803 NLTATFAVIWGG----------SKPLDNPHNIHVVIYRCREMADSCGICLAL-SEKYNCGWCSST 856
            :....|.|||..          ::.|||..::.:.:|.|..:|.:||.||.| ::||:|||||..
Worm   786 STPYGFNVIWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLD 850

  Fly   857 NTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGV 921
            :.|....||: |::...:|||.|::||||.|..|:||.|...|||.:||.|||||::.:|:...|
Worm   851 SKCARPHQCS-NRQIPENWLNASQLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAV 914

  Fly   922 RIAGINCMPFPQFYIDTKQIVC-TVDSPGEQMYRNGKIVVQIG----DYRGESKEDYEFVDPKIL 981
            :||.:.|....  |:.:::||| |..||.:.....|.:.|.:.    .:...|.|.:.:|.|.:.
Worm   915 QIANVPCEVVE--YVPSQKIVCVTGKSPIKGSNERGVVAVTLRHDSLKFFAHSTEHFSYVQPVVS 977

  Fly   982 DFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKM 1046
            ...|..||.||||::.:||..|:.|:.:..... .:.||||...|....||..||....:..|.:
Worm   978 SMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFG-QIGCKILERASGWLRCRMGASGEGGQFPLHI 1041

  Fly  1047 SFD----NGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNI 1107
            :||    |.|...   .|::..||:|:.:|..        |.||:|||.:.|.|..||.:|.|.
Worm  1042 AFDGQLQNLPIPI---YFEFTSDPSVQSISPN--------KTIPSGGITVDVYGQGFTLLQRPR- 1094

  Fly  1108 YVVYNG----EMYASPCRVQSDTEMECASPVV-DVDSHVIEAERPILLEYGFLMDNVLRVQNLSK 1167
             :|:.|    :.|...|.::.|..|:||:|.. ..||.....||  :.||.|..|.       ::
Worm  1095 -MVFTGLGDEKSYGPACSIEDDQMMKCATPTAPGKDSDRGSQER--ITEYAFDFDG-------AE 1149

  Fly  1168 VHNNHFELYPNPEY-FIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQL 1231
            ::.:..::.|:|.: .:.|.|......::||:||.:|:.|..|.|::||:|...|.:|:|:.:.|
Worm  1150 LYRSRIKVMPSPTFETLSEPRFVRPGEDFLTLNGNHLNLAASERDIDVKVGGEPCPLTALANKVL 1214

  Fly  1232 TCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFV 1296
            ||:||.:.........||::|.:|.: .:.||.:||:|..:    ..::.|.::..|:.::.:.:
Worm  1215 TCQPPVKKPRGAGKLNPEIVVTVGNA-SFSIGEVSYDSPGL----SSSLFFIIMFFIIFMIALII 1274

  Fly  1297 ALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSG--GIPFLDY 1359
            .|:|.|::||:...|.::.::.|||.:|::||.|||||||||||.:...|.||..|  ..|||:|
Worm  1275 CLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTADLPLGTPTAPFLEY 1339

  Fly  1360 RSYAMKILFPN-HEDHIVLQ-----WERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFS 1418
            :.|..::|||| .::|.||:     ..:.|.:  |.|||.|.:|:|||||||..:||:|:|:||.
Worm  1340 KDYCARVLFPNAGKNHAVLKNLEVDTHKAEAI--EAGLREFHKLLMNKTFLLTMVRTMEANKYFV 1402

  Fly  1419 MRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTF 1483
            .::||.|.||:||.||.|:.|||::||.||.:||||.:|.|..||:|.||:||:||:||:|||||
Worm  1403 GKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKFQPKILFRRSESIAERMLAAWFTF 1467

  Fly  1484 LLYKFLKEC-AGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQ 1547
            ||:..||.. ||:.||.||..:|.|::|||.||.|.|||||||||||:|.:.:::.:.|:.|.
Worm  1468 LLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLLRATFEYKELMVFVSA-- 1530

  Fly  1548 QPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGR 1612
                   .|.:.|.|:::.|:|||||||.|||||||:..||....:.||...|::|||:||..|:
Worm  1531 -------SDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELEWKTGMNGK 1588

  Fly  1613 VILYDEDVTSKTE-SEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNF-----------SILSDKNE 1665
            :.|.|.|.:|:.| ..||:||||.|||||:.|.|:|..|.:|:||.           |||||::|
Worm  1589 MALQDIDSSSRVEGGNWKRLNTLAHYNVPNNAILTLTSKSNSLYNLVNFSSTSMKTASILSDRSE 1653

  Fly  1666 KSH---KYETLNISKYTSSSPTF--SRAGSPLNNDMHENGLRYWHLVK---HHDSDMQKEGERVN 1722
            ||.   |...:...|...:.|:.  ..|.|..:.|   ||.:.:||||   |..:|.|:
Worm  1654 KSSVSMKTPGVGSPKPWGAPPSVIADHASSSADTD---NGFKLYHLVKPTEHGPTDSQE------ 1709

  Fly  1723 KLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVV 1787
            |:|:||||||||..||||.||:..|.|:|||:    |.:|..|||||||:|:||:.|||.|||||
Worm  1710 KMVTEIYLTRLLMMKGTLAKFITSLLESIFSS----STVPPCIKYMFDFMDEQAREHGINDPEVV 1770

  Fly  1788 HTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLY 1852
            |.||||:|||||||||||||:|:|||.|...::.||||||||.||:|||.||:|.|||||||||:
Worm  1771 HAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCLSVVAQTLMDACSTQDHQLTKDSPSSKLLF 1835

  Fly  1853 AKDIPEYRKWVDRYYRDIRDMSP-ISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQL 1916
            |||:.:||..||.||.:| .|:| |.|..|.|.|:.|||.|..||:...||:|||.|..:|.|.:
Worm  1836 AKDMYQYRDLVDSYYTEI-SMTPRIDDATMGANLSAESRQHNGEFHVFSALNELYKYLDQYKESI 1899

  Fly  1917 TVTLEEDEFSQKQRLAFKLEQVHNIMSSE 1945
            ...||.:|.:|..||..:|:.:..:|.|:
Worm  1900 IDALESNEHAQASRLPGRLQDLLALMESD 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	171/474 (36%)
		PSI	522..574	CDD:279745	18/53 (34%)
		PSI	671..>699	CDD:279745	14/27 (52%)
		PSI	830..883	CDD:279745	22/53 (42%)
		IPT_plexin_repeat1	885..977	CDD:238585	32/96 (33%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/88 (31%)
		IPT	1078..1177	CDD:301692	29/103 (28%)
		IPT_PCSR	1196..>1255	CDD:238337	22/58 (38%)
		Plexin_cytopl	1353..1916	CDD:285529	298/590 (51%)
plx-1	NP_001294554.1	Sema_plexin_like	42..495	CDD:200497	169/463 (37%)
		PSI	496..550	CDD:366642	18/53 (34%)
		TIG_plexin	557..649	CDD:375449	28/92 (30%)
		PSI	650..710	CDD:366642	25/59 (42%)
		TIG_2	717..822	CDD:375492	30/106 (28%)
		PSI	823..876	CDD:366642	22/53 (42%)
		IPT_plexin_repeat1	878..973	CDD:238585	32/96 (33%)
		IPT_PCSR	974..1059	CDD:238337	27/88 (31%)
		IPT	1062..1146	CDD:387656	31/95 (33%)
		IPT_PCSR	1179..1248	CDD:238337	25/69 (36%)
		Plexin_cytopl	1333..1897	CDD:369821	297/588 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	528	1.000	Domainoid score	I141
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1239	1.000	Inparanoid score	I85
Isobase	1	0.950	-	0	Normalized mean entropy	S4424
OMA	1	1.010	-	-		QHG48715
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		oto20424
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	LDO	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.920