DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Plxna4

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_786926.2	Gene:	Plxna4 / 243743	MGIID:	2179061	Length:	1893	Species:	Mus musculus

Alignment Length:	1949	Identity:	823/1949 - (42%)
Similarity:	1141/1949 - (58%)	Gaps:	190/1949 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 NHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVRSPTDNY 136
            |||:||..||.:::|.|||:|:||.||::..|.:|||..|:.:|    .:..|  |...:.|:|.
Mouse    51 NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTC--NEPLASTNNV 113

  Fly   137 NKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD--------AVVANDANS 186
            ||:||||...:||||||||:||.|.:..|:::..:       ||.:..        .|:.:.:|.
Mouse   114 NKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYSNF 178

  Fly   187 STVAFIA---PGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTK----MF------QIA 238
            ....|||   .|.|::                     .|.::||.|.|..    ||      :..
Mouse   179 DDKLFIATAVDGKPEY---------------------FPTISSRKLTKNSEADGMFAYVFHDEFV 222

  Fly   239 SSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQ--LKHSHHSSPKE--YITKLVRICQ 299
            :|.:...:.||.   ....:.:.|||||||..|.||||.|  :.....|:.||  |.:||||:|:
Mouse   223 ASMIKIPSDTFT---VIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCK 284

  Fly   300 EDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN-- 362
            ||:.:.||.|:|:.|   .:.|.::.|:||.:|.|..:.|.::||:...||:||.|||||:..
Mouse   285 EDTAFNSYVEVPIGC---ERNGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLLFTVFSKGQKRKM 346

  Fly   363 TPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFIS-PSMPCVLTKLQTIGEDFCGLDVNS 426
            ...:.|||||:.||.|..:....::||:.|.|...|.::. ..:|| .:.|.||.::|||||:|:
Mouse   347 KSLDESALCIFILKQINDRIKDRLQSCYRGEGTLDLAWLKVKDIPC-SSALLTIDDNFCGLDMNA 410

  Fly   427 PLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIES-SSIANEYASFAVD 489
            |||....:..:|| .....::|||.|.....:::.||||..|.|||:.::. ...|.:|.:..|.
Mouse   411 PLGVSEMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPKGNALQYETVQVV 475

  Fly   490 LGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSN 554
            ....:.|||.|...:..:|:||:.::::|.|..|..|::||:|||:.||:||||.|.|.|:.:..
Mouse   476 DSGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYRSCGECLGSGDPHCGWCVLHNTCTRKER 540

  Fly   555 CQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAF--TTEDK 615
            | :.:.:|..:.| :..:|..:| |.|:.:..:....| |:::  ::|:|...:.|.|  .:|..
Mouse   541 C-ERSREPRRFAS-EMKQCVRLT-VHPNNISVSQYNVL-LVLETYNVPELSAGVNCTFEDLSEMD 601

  Fly   616 ALFTNATKKRNGVNCTTPRTDMLPQI--EQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSS 677
            .|...     |.:.|.:|....:|:|  |.|.|| ..:|.:::: .|....||.|.|::||.|:|
Mouse   602 GLVIG-----NQIQCYSPAAKEVPRIITENGDHH-VVQLQLKSKETGMTFASTSFVFYNCSVHNS 660

  Fly   678 CTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINATGDGS 738
            |..||.|.:.|.||...|.|||| ...|              |::.|    |..||.:...   .
Mouse   661 CLSCVESPYRCHWCKYRHVCTHD-PNTC--------------SFQEGRVKLPEDCPQLLRV---D 707

  Fly   739 EVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEG---RVTSLNAQLLGDTIYCDSMEFQYTS 799
            ::||.....|.|.:|...:.| ...|..:.|..||:|   ||.:|  :....::.|.:..:.|..
Mouse   708 KILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGIEQRVPAL--RFNSSSVQCQNTSYSYEG 770

  Fly   800 RS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEE 863
            .. .||.....|:|.|...:|||....|.:|:|..|.:|||:||.....:.||||.|...|.:.:
Mouse   771 MEINNLPVELTVVWNGHFNIDNPAQNKVYLYKCGAMRESCGLCLKADPDFECGWCQSPGQCTLRQ 835

  Fly   864 QCNKNKEGKTDWLNRS---EICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG 925
            .|..:   ::.||..|   ..|.||.|....|.|||.||||.:||||.|||..:.||.|.|::||
Mouse   836 HCPAH---ESRWLELSGANSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAG 897

  Fly   926 INCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQI------GDYRGESKEDYEFVDPKILDFN 984
            :.|.|....||..:||||.:   ||.........|:|      .::...|.:.|.|:...:.|..
Mouse   898 VECSPLVDGYIPAEQIVCEM---GEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLADLK 959

  Fly   985 PKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFD 1049
            |..||.||||::.|||.:|||||.:....... ||.......|..||.|::|..:::.::.:..|
Mouse   960 PNRGPMSGGTQVTITGTNLNAGSNVVVMFGSQ-PCLFHRRSPSYIICNTTSSEEVLDMKVTVQVD 1023

  Fly  1050 NGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNIYVVYNG 1113
            .. |...|..|:||.|||:..:.         |: .|.:|...|:|.||....||||.|...:.|
Mouse  1024 RA-RIRQDLVFQYVEDPTIVRIE---------PEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGG 1078

  Fly  1114 EMYASPCRVQSDTEMECASPVVDV--DSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELY 1176
            :.:.:.|.|.:.|||.|.:|.:.:  |......|||  .|:||::||   ||:|..::..:|..|
Mouse  1079 KEHINICEVLNATEMTCQAPALALGPDHQSDLTERP--EEFGFILDN---VQSLLILNKTNFTYY 1138

  Fly  1177 PNPEYFIFEER--VKYFKSEYLTINGRNLDRACKESDVE----VKIGNGFCNITSLSRQQLTCRP 1235
            |||.:..|...  ::......:.:.|:||.......:|:    |.:|...|.:| :|..||.|..
Mouse  1139 PNPVFEAFSPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVT-VSDVQLLCES 1202

  Fly  1236 PSEATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLV 1300
            |:      .:...:|:.|:| .:||..|:: |.:.:..|.....|..||...::|:.:  ||:|:
Mouse  1203 PN------LIGRHKVMARVG-GMEYSPGMV-YIAPDSPLSLPAIVSIAVAGGLLIIFI--VAVLI 1257

  Fly  1301 AYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMK 1365
            |||:||.||...|:.:|.|||.||.|||.|||||||||||::.:||.||...||||||||:|.|:
Mouse  1258 AYKRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMR 1322

  Fly  1366 ILFPNHEDHIVLQ-----WERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNV 1425
            :|||..|||.||:     ..|.|  |.||||::|.|||.||.|||.|||||||.|.||||:|.||
Mouse  1323 VLFPGIEDHPVLRDLEVPGYRQE--RVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNV 1385

  Fly  1426 ASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLK 1490
            |||||..|||||||.||:||.||.|||:|.:|.|:|||||||||||||||||:.|||||||||||
Mouse  1386 ASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLK 1450

  Fly  1491 ECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNL 1555
            |||||||:.||.|:|.|::|||:||.|.||||||||:|||||.|:::.:         .:.|.:.
Mouse  1451 ECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTL---------VLSCVSP 1506

  Fly  1556 DMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDV 1620
            |.:  ::..|.||:|:||||.|||||.|:.|::|:|.|.||:..|:|||||.|:..|:||.|||:
Mouse  1507 DNV--NSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDI 1569

  Fly  1621 TSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKS-HKYETLNISKYTSSSPT 1684
            |:|.|::||:|||:.||.||||:.::||.||.:.||....|..:..| .|||  |:.:|| .||.
Mouse  1570 TTKIENDWKRLNTVAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASKYE--NMIRYT-GSPD 1631

  Fly  1685 FSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFE 1749
            ..|:.:|:.....|:|::.|||||:|:...||||:|.:|:|||||||||||||||||||||||||
Mouse  1632 SLRSRTPMITPDLESGVKLWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFE 1696

  Fly  1750 TIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIH 1814
            ||||||||||||||||||||||||:||..|||.||.|.||||||.||||||||:||||.||||||
Mouse  1697 TIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIH 1761

  Fly  1815 KSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQ 1879
            |::|.|:||||||||||||||||:|||||||||:|||||||||.|:.||:|||.||..|..||||
Mouse  1762 KNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQ 1826

  Fly  1880 DMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMS 1943
            ||||.|||:||:|..||||..||.|:::|..||:|::...|:.|:...||:||:|||||..:||
Mouse  1827 DMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMS 1890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	162/484 (33%)
		PSI	522..574	CDD:279745	19/51 (37%)
		PSI	671..>699	CDD:279745	13/27 (48%)
		PSI	830..883	CDD:279745	17/55 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	38/97 (39%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/84 (32%)
		IPT	1078..1177	CDD:301692	33/101 (33%)
		IPT_PCSR	1196..>1255	CDD:238337	15/62 (24%)
		Plexin_cytopl	1353..1916	CDD:285529	366/568 (64%)
Plxna4	NP_786926.2	Sema_plexin_A4	38..510	CDD:200535	163/488 (33%)
		PSI	509..547	CDD:214655	17/38 (45%)
		PSI	654..701	CDD:279745	20/61 (33%)
		PSI	803..855	CDD:279745	17/54 (31%)
		IPT_plexin_repeat1	857..952	CDD:238585	38/97 (39%)
		IPT_plexin_repeat2	954..1037	CDD:238584	28/84 (33%)
		IPT_plexin_repeat3	1039..1139	CDD:238586	35/113 (31%)
		IPT_PCSR	1141..1221	CDD:238337	19/87 (22%)
		Plexin_cytopl	1310..1863	CDD:285529	366/568 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1362	1.000	Inparanoid score	I132
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm43935
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	LDO	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860