DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexA and PLXNB2

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_001363793.1 Gene:PLXNB2 / 23654 HGNCID:9104 Length:1917 Species:Homo sapiens


Alignment Length:2068 Identity:657/2068 - (31%)
Similarity:987/2068 - (47%) Gaps:393/2068 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVR----SP 132
            :.:||||.||..:|.|::|.||.||||...|:|.:.|.|||..|:.:|:   .|:.|.:    ..
Human    31 EKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCT---PPIEASQCHEAEM 92

  Fly   133 TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSI-IEHE----VPDAVVANDANSSTVAFI 192
            |||.|::||:|....||:.|||||:|.|.:|.|.|:|: :.:|    ....|.:||...:||..:
Human    93 TDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLV 157

  Fly   193 A---PGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKT---KMFQIASSAVT-------T 244
            :   ||..:     |::||   ..|.|:.:.| .|::|.|::|   :.|:..:...|       |
Human   158 SSTGPGGDR-----VLFVG---KGNGPHDNGI-IVSTRLLDRTDSREAFEAYTDHATYKAGYLST 213

  Fly   245 GTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTE 309
            .|:.|:.::....| |.:|:           ..|.||     |....|.|.|:|:||.|||||.|
Human   214 NTQQFVAAFEDGPY-VFFVF-----------NQQDKH-----PARNRTLLARMCREDPNYYSYLE 261

  Fly   310 IPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPTNNSALCIYS 374
            :.::|.........|....|..:..|.|           ..||:||||:...::....:.||::.
Human   262 MDLQCRDPDIHAAAFGTCLAASVAAPGS-----------GRVLYAVFSRDSRSSGGPGAGLCLFP 315

  Fly   375 LKSIRRKFMQNIKSCFNGSGMRGLDFISP----------------SMPCVLTKLQTIGEDFCGLD 423
            |..:..|...|..:|:.|:......|..|                |.||        |.:    .
Human   316 LDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPC--------GSE----H 368

  Fly   424 VNSPLGGETPITSVPVAM-FNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFA 487
            :..|||....:....|.. ....||:|...:.:.:||.|:|||||.:.||.:.....::||.|..
Human   369 LPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSIL 433

  Fly   488 VDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPR 552
            |::...:.||:........:|.|::.||.::.|.:|..|.||..|..::|||||||.:|.:|:.:
Human   434 VEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRK 498

  Fly   553 SNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQLKE--NLICAFTTEDK 615
            :.| ..|.:..:|:..::..|..:||..|..:.|.....::|.:..||.|.|  .|:|.|.....
Human   499 AEC-PRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPP 562

  Fly   616 ALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGP-DLVSTDFTFFDCSTHSS-- 677
               ..|..:...|.|.:|.:  :|....|:.|....:.:..|.|. .|.|..:.|:||....|  
Human   563 ---HPARVEGEAVICNSPSS--IPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLE 622

  Fly   678 ----CTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGS 738
                |..|||:.:.|.|.:..|.| .:.:.|..:.|:...:.          ..||         
Human   623 ENLPCISCVSNRWTCQWDLRYHEC-REASPNPEDGIVRAHME----------DSCP--------- 667

  Fly   739 EVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQ------LLGDTIY--CDSMEF 795
                                ||:..:..|...|.|   |.:|.|      :.|.:::  .|.::|
Human   668 --------------------QFLGPSPLVIPMNHE---TDVNFQGKNLDTVKGSSLHVGSDLLKF 709

  Fly   796 Q----------YTSRSPNLT---------ATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGIC 841
            .          :..|:|.|:         ..:...:|  |.:|:  .:||.:|.|......|.:|
Human   710 MEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYG--KNIDS--KLHVTLYNCSFGRSDCSLC 770

  Fly   842 LALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIR 906
            .|.:..|.|.||...:.|..|..||...|           ||.|.|...||:|||..||..|||.
Human   771 RAANPDYRCAWCGGQSRCVYEALCNTTSE-----------CPPPVITRIQPETGPLGGGIRITIL 824

  Fly   907 GINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGESKE 971
            |.|||....|| ..:.:||.||...|:.|..:.:|||.::: .|..:..| :.|.:....|.|..
Human   825 GSNLGVQAGDI-QRISVAGRNCSFQPERYSVSTRIVCVIEA-AETPFTGG-VEVDVFGKLGRSPP 886

  Fly   972 DYEFV--DPKILDFNPKFGPTSGGTEIHITGKHLNAGSR--IQASINDHLPCKILSTDSSQAICR 1032
            :.:|.  .||.|...|:.||.:|||.:.|.|.||:.||:  ::.::|. :|||: :...:|..|.
Human   887 NVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNG-VPCKV-TKFGAQLQCV 949

  Fly  1033 TSASPGIIEGRLKMSFDNG------PREFNDYNFKYVLD-------------------------- 1065
            |  .|....|::.:....|      |..|..|....||.                          
Human   950 T--GPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFARNPDGHTRGSTLTRPRV 1012

  Fly  1066 --------------------PTVEHVSS----------GPSGQIKVPKGIPA-----------GG 1089
                                ||..|..:          |..|:.:.....||           ||
Human  1013 PPAHLRHSLVLSTSHRVAPLPTETHTCTWKPRVVRARVGGDGRAEAAGTTPASRAHEGTALRSGG 1077

  Fly  1090 IRISVTGTQFTSIQNPNIYVVYNGEMYASPCRV-QSDTEMECASPVVDV--------DSHVI--- 1142
            ..|:|||..|:.||...:.|:      |.|.:. |...|.|...|:..|        |:.|:   
Human  1078 RSINVTGQGFSLIQRFAMVVI------AEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLS 1136

  Fly  1143 --EAERP------ILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTIN 1199
              ..|.|      :|:|    ||.   .:.|.:.....||..|:|.:..|...||...::.:...
Human  1137 PAVPEEPEAYNLTVLIE----MDG---HRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHAR 1194

  Fly  1200 GRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATK-------SMNGPEVIVRIGTS 1257
            |.||::|....:.|..:|...|.:.:|:...|.|.||......|       :.|.||.||:.| |
Human  1195 GTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFG-S 1258

  Fly  1258 LEYRIGILSYES--SNIILDWGENVIFAVIATIVILLLIFVALLV-AYKKKSSESSRVLRNMQEQ 1319
            .|:.:|.:.|::  |::.|.       .::..:::.:::.:|:.| .|.:||.::.|....::.|
Human  1259 REWVLGRVEYDTRVSDVPLS-------LILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQ 1316

  Fly  1320 MDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHED-----HIVLQW 1379
            ::.||..|...||:.|.:|..||.|.|.|:...|||.|||::|..::.|...:|     .|..:.
Human  1317 LEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKL 1381

  Fly  1380 ERPELLRK--EKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTD 1442
            :.||..|.  |:.|..|..|:.:|:||:.||.|||:.|.||.|.:|..|||:.|.|..||||.||
Human  1382 DIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTD 1446

  Fly  1443 ILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQ 1507
            |:.||..:|:|:.:..| :|||:|||:|:|.|:|||.|.:..||::||:.||||||.||:|:|.|
Human  1447 IMHTLFLELLEQYVVAK-NPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQ 1510

  Fly  1508 VDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDC 1572
            |:||||||...:|:|:|::..|:...:::.|:.|  |:|.|.   ..:|.:|       ||||:|
Human  1511 VEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTV--SVIVQD---EGVDAIP-------VKVLNC 1563

  Fly  1573 DTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHY 1637
            |||.|||||.::.:||..|.|..||.|.:.||||.|:|.: ||.|.|:||:.|..||::|||.||
Human  1564 DTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQ-ILSDLDLTSQREGRWKRVNTLMHY 1627

  Fly  1638 NVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKY-TSSSPTFSRAGSPLNNDMH---E 1698
            ||.|||                            ||.:||. .|..|..|:...|  .:.|   |
Human  1628 NVRDGA----------------------------TLILSKVGVSQQPEDSQQDLP--GERHALLE 1662

  Fly  1699 NGLRYWHLVKHHDS--------DMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTA 1755
            ...|.||||:..|.        ...||.|| .|.::||||||||:.|||||:|||:.|:::.:..
Human  1663 EENRVWHLVRPTDEVDEGKSKRGSVKEKER-TKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPG 1726

  Fly  1756 HRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVD 1820
            |   |:|.|:||.|||||:||:.|.|.|.:.:|.||:||||||||||::|||:|:||:|...:||
Human  1727 H---AVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVD 1788

  Fly  1821 SCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAML 1885
            :.|||:||||||:|:.::|:|.:||||:||||||:|..|:|.|:.||:.||.|..:||||||..|
Human  1789 ASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHL 1853

  Fly  1886 AEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQV 1938
            ||.||.||...||..|||:||.|..||.:::...||||..:||.:|||:|:|:
Human  1854 AEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQI 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 138/483 (29%)
PSI 522..574 CDD:279745 17/51 (33%)
PSI 671..>699 CDD:279745 11/33 (33%)
PSI 830..883 CDD:279745 13/52 (25%)
IPT_plexin_repeat1 885..977 CDD:238585 33/93 (35%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/92 (30%)
IPT 1078..1177 CDD:301692 30/129 (23%)
IPT_PCSR 1196..>1255 CDD:238337 18/65 (28%)
Plexin_cytopl 1353..1916 CDD:285529 268/581 (46%)
PLXNB2NP_001363793.1 Sema_plexin_B2 27..467 CDD:200537 138/487 (28%)
PSI 468..518 CDD:214655 17/50 (34%)
TIG_plexin 526..613 CDD:375449 21/91 (23%)
PSI 759..>799 CDD:366642 12/39 (31%)
IPT_plexin_repeat1 803..894 CDD:238585 33/93 (35%)
IPT_plexin_repeat2 895..981 CDD:238584 28/89 (31%)
Plexin_cytopl 1350..1883 CDD:369821 268/580 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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