DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and PLXND1

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_055918.3 Gene:PLXND1 / 23129 HGNCID:9107 Length:1925 Species:Homo sapiens


Alignment Length:2072 Identity:654/2072 - (31%)
Similarity:987/2072 - (47%) Gaps:416/2072 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 TKLNHLLVDTITGRVFVGGVNRLYQLS-PDLELSETVKTGPQNDSVECSILDCPLNAVRSP---T 133
            |..|:..:|...|.|::..|||||||| .:|.|......||..||..|.....|..:...|   |
Human    57 TPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLT 121

  Fly   134 DNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDA---------------VVAND 183
            |||||:|.:|.....::.|||::||.|.:|...|:|.:....|.|               |.||.
Human   122 DNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANH 186

  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYT---------NNS--PYRSE-IPAVASRSLEK----T 232
            .|:|||..:.| |......:.:.||.|||         |.|  .:|.| .|.:|.|||:.    .
Human   187 PNASTVGLVLP-PAAGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLA 250

  Fly   233 KMFQIASSAVTTGTRTF-----------INSYARETYFVNYVYGF--------SSERFSYFLTTQ 278
            |:|            ||           |...|:|.:.:.:|..|        .::.::|.   .
Human   251 KLF------------TFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAYL---A 300

  Fly   279 LKHSHHSSPKEYITK--LVRICQE-----DSNYY--SYTEIPVECISDAQGGTKFNLVQAGFLGK 334
            |.....:..||...:  |.|||..     |:...  ||.::.::|...|..|..::.:.:.|..:
Human   301 LNSEARAGDKESQARSLLARICLPHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPAR 365

  Fly   335 PSSDLAQSLGISIQDDVLFAVFSKGEGNTPTN--NSALCIYSLKSIRRKFMQNIKSCFNGSGMRG 397
                           :.|||||.:.:|:....  .:|||.:....:|........:|        
Human   366 ---------------ERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTAC-------- 407

  Fly   398 LDFISPSMPCVLTKLQTIGEDF------------------CG-LDVNSPLGGETPITSVPVAMFN 443
              |:.|: |.|:..|.::.:..                  || ..:..||....|:.:.||  |.
Human   408 --FVEPA-PDVVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPV--FR 467

  Fly   444 TK-LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNL-Y 506
            .. |||||..|.:.||.||:||.:|.|.|:.:..|..........|..|..::..||||..:. |
Human   468 APGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSGY 532

  Fly   507 IYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTG 571
            :|:|:..::::|||..|:.:.|||||:||.|.|||||:||.:|:.:.:|.:.:... :|.|...|
Human   533 LYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQH-FWTSASEG 596

  Fly   572 --KCTTITSVVPHQL---QRTTARTLELIIDHLPQLK-ENLICAFTTEDKALFTNATKKRNGVNC 630
              :|..:| |:|.::   |......|: |...||.|. ..:.|.:                |.|.
Human   597 PSRCPAMT-VLPSEIDVRQEYPGMILQ-ISGSLPSLSGMEMACDY----------------GNNI 643

  Fly   631 TT-------------------PRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCS--- 673
            .|                   || |..|.....:.|.|.::|||. ||.::|..:||.:|||   
Human   644 RTVARVPGPAFGHQIAYCNLLPR-DQFPPFPPNQDHVTVEMSVRV-NGRNIVKANFTIYDCSRTA 706

  Fly   674 ---THSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYR-SGPGFCP-TINA 733
               .|::||.|:|:::||.||.:.|.|             |:..||...|.. :.|..|| |:.:
Human   707 QVYPHTACTSCLSAQWPCFWCSQQHSC-------------VSNQSRCEASPNPTSPQDCPRTLLS 758

  Fly   734 ------TGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFV------CQFNIEGRVTSLNAQLLGD 786
                  ||....:||.                 :..|.|.      |.|.:|   ....|..:.:
Human   759 PLAPVPTGGSQNILVP-----------------LANTAFFQGAALECSFGLE---EIFEAVWVNE 803

  Fly   787 TIY-CDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSE-KYN 849
            ::. ||.:....|.:|.....:..:....::.||:|..:.|::|.|...:..|..||...: .:.
Human   804 SVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHL 868

  Fly   850 CGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNY 914
            |.|   ::.|.:......          .:..||.||||..:|.:||.:|||.:||||.|||:..
Human   869 CMW---SDGCRLRGPLQP----------MAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRL 920

  Fly   915 NDIYSGVRIAGINCMPFPQFYIDTKQIVC-TVDSPGEQMYRNGKIVVQIGDYRGESKEDYEFVDP 978
            :|:..||.|.|:.|.|.|..|..:::||| |..:||.   .:|.:.|. ....|:|::.:.:|.|
Human   921 SDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGP---LSGVVTVN-ASKEGKSRDRFSYVLP 981

  Fly   979 KILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPC-KILSTDSSQA------------- 1029
            .:....|..||.:|||.|.|.|..|:.||.:|..:||..|| :::.||:|.|             
Human   982 LVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVP 1046

  Fly  1030 ICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIP-AGGIRIS 1093
            :|......|.:.|.|              .|.|:.:|.:..:|         |:..| :||..|:
Human  1047 VCVRFERRGCVHGNL--------------TFWYMQNPVITAIS---------PRRSPVSGGRTIT 1088

  Fly  1094 VTGTQFTSIQNPNIYVVYNGEMYASP--CRVQSDTEMECASPVVDVDSHVIEAERPI--LLEYGF 1154
            |.|.:|..:||.::.|.:.|.   .|  |:|.:.|.:.|.||     ..:..|..|:  .:....
Human  1089 VAGERFHMVQNVSMAVHHIGR---EPTLCKVLNSTLITCPSP-----GALSNASAPVDFFINGRA 1145

  Fly  1155 LMDNVLRVQNL----SKVHNNHFEL--YPNPEYFIF--EERVKYFKSEYLT--INGRNLDRACKE 1209
            ..|.|...:.|    .....:.|.|  .|||::...  |:.:|:...|.||  |:........:.
Human  1146 YADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQS 1210

  Fly  1210 SDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIG-TSLEYRIGILSYESSNII 1273
            .:..||||...|:|..:|.:.:.|      :..:|:.     ..:| ..:..::|..:...:.:.
Human  1211 HEYRVKIGQVSCDIQIVSDRIIHC------SVNESLG-----AAVGQLPITIQVGNFNQTIATLQ 1264

  Fly  1274 LDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAEL 1338
            |...|..|...|....:|||:.|..|..:..||..:.|..:....||:.:|.::..|.::.||||
Human  1265 LGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAEL 1329

  Fly  1339 QTEMTDLTGDLT-SGGIPFLDYRSYAMKILFPN----HEDHIVL--------------------- 1377
            ||:|||||.:|. |.|||||:|:.:..:..||.    :|:..||                     
Human  1330 QTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLG 1394

  Fly  1378 QWERPELLR--KEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYC 1440
            :|:.||..|  .|:|:.:|..|:.||.||::|:..||..:.|::|:|.::|||:.:.|..||||.
Human  1395 EWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYY 1459

  Fly  1441 TDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVK 1505
            |.|:|.||.|||:  .....:|||:|||||||.||||:.|.:..:|..|:|..|||.::|..|:|
Human  1460 TSIMKELLVDLID--ASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIK 1522

  Fly  1506 GQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVL 1570
            .|::||.:||.|.:|||:||||.|:|::|:.:|.|:            |:.......:::||:.:
Human  1523 QQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNL------------NVSFQGCGMDSLSVRAM 1575

  Fly  1571 DCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQ 1635
            |.||:.|||||.||...:|:|.||.||.:|:||||...:|...||.|.|.||..|...||||||.
Human  1576 DTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLA 1640

  Fly  1636 HYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSPLNNDMHENG 1700
            ||.:|:||.|::          |::..|:....:.:.|:..|                       
Human  1641 HYKIPEGASLAM----------SLIDKKDNTLGRVKDLDTEK----------------------- 1672

  Fly  1701 LRYWHLV----------KHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTA 1755
              |:|||          |.|....:|      |::.||||||||:||||||||:||||:.|.|. 
Human  1673 --YFHLVLPTDELAEPKKSHRQSHRK------KVLPEIYLTRLLSTKGTLQKFLDDLFKAILSI- 1728

  Fly  1756 HRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVD 1820
             |....|||:||.||||::||:..||:||:.:|.||:||||||||||::|||.|||||.|::.:|
Human  1729 -REDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHID 1792

  Fly  1821 SCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAML 1885
            :||||:||.|:|:||.||.:||||||::||||||:||||||.|.|||:.|:||:|:|:|:|||.|
Human  1793 ACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHL 1857

  Fly  1886 AEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIM 1942
            |||||.:..|||||.|:.|:|.||.:|..|:...||.:..:::.:|..|.|||..:|
Human  1858 AEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALM 1914

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 137/530 (26%)
PSI 522..574 CDD:279745 21/53 (40%)
PSI 671..>699 CDD:279745 14/33 (42%)
PSI 830..883 CDD:279745 7/53 (13%)
IPT_plexin_repeat1 885..977 CDD:238585 36/92 (39%)
IPT_plexin_repeat2 978..1063 CDD:238584 27/98 (28%)
IPT 1078..1177 CDD:301692 26/109 (24%)
IPT_PCSR 1196..>1255 CDD:238337 12/60 (20%)
Plexin_cytopl 1353..1916 CDD:285529 264/599 (44%)
PLXND1NP_055918.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Sema_plexin_D1 49..547 CDD:200508 139/533 (26%)
PSI 549..601 CDD:396154 21/52 (40%)
TIG_plexin <627..700 CDD:407808 21/90 (23%)
PSI 711..753 CDD:214655 16/54 (30%)
IPT_plexin_repeat1 891..979 CDD:238585 36/91 (40%)
IPT_plexin_repeat2 981..1067 CDD:238584 28/99 (28%)
IPT_plexin_repeat3 1069..1174 CDD:238586 28/121 (23%)
Plexin_cytopl 1345..1888 CDD:400574 264/599 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I9806
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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