DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Mst1r

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_006511717.1	Gene:	Mst1r / 19882	MGIID:	99614	Length:	1406	Species:	Mus musculus

Alignment Length:	1739	Identity:	343/1739 - (19%)
Similarity:	533/1739 - (30%)	Gaps:	681/1739 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVRSPTDNYNKVLLIDRA 145
            |:....|||...|.|:.|.|||:..|.:.|||..:....:...|.......|.|....||:::..
Mouse    65 DSTNSAVFVATRNHLHVLGPDLQFIENLTTGPIGNPGCQTCASCGPGPHGPPKDTDTLVLVMEPG 129

  Fly   146 TSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDAVV--ANDANSSTVAFIAPGPPQHPVTNV---- 204
            ...|::|||..||.|.:..|:......|....|.:  ||:............|....||.|
Mouse   130 LPALVSCGSTLQGRCFLHELEPRGKALHLAAPACLFSANNNKPEACTDCVASPLGTRVTVVEQGH 194

  Fly   205 ---MYVGVTYTNNSPYRSEIPA------VASRSLEK-TKMFQIASSAVTTGTRTFINSYARETYF 259
               .||.      |....|:.|      |:.|.|:. |..||....:::.     :..|. .:|.
Mouse   195 ASYFYVA------SSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSV-----LPKYL-ASYL 247

  Fly   260 VNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVEC-------ISD 317
            :.|||.|.|..|.||||.| ..|..|.|....|:|||:...:.....|.|:.::|       ...
Mouse   248 IKYVYSFHSGDFVYFLTVQ-PISVTSPPSALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRRG 311

  Fly   318 AQGGTK-FNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVF----SKGEGNTPTNNSALCIYSLKS 377
            |..||: :.::||.......:.||..|.||...:|||.||    ..|.|..|  ||.:|.:.:..
Mouse   312 APEGTQPYPVLQAAHSAPVDAKLAVELSISEGQEVLFGVFVTVKDGGSGMGP--NSVVCAFPIYH 374

  Fly   378 IRRKFMQNIKSCFNGSG-----MRGLDFI-SPSMPCVLTKLQTIGEDFCGLDVNSPLGGET---- 432
            :.....:.::.|.:.|.     .|||||. :||              ||    .:|.|||.
Mouse   375 LNILIEEGVEYCCHSSNSSSLLSRGLDFFQTPS--------------FC----PNPPGGEASGPS 421

  Fly   433 ------PI----TSVPVAMFN-----TKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANE 482
                  |:    :...|.:||     .|:|::..|.....||..:||.||.:.:|.|..|.....
Mouse   422 SRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTVDGRVLQVEIARSLNYLL 486

  Fly   483 YAS-FAV-DLGSEINRDM-QFDNQNLYIYVMSKTKVSKVKVF--DCSDYKTCGDCLGA-RDPYCG 541
            |.| |:: ..|..::||: :..|..|:   .|..:|.||.:.  .|..:.||..||.| |...||
Mouse   487 YVSNFSLGSSGQPVHRDVSRLGNDLLF---ASGDQVFKVPIQGPGCRHFLTCWRCLRAQRFMGCG 548

  Fly   542 WCSLENKCSPRSNCQDDANDPLYWVSYKTGKC-TTITSVVPHQ--LQRTTARTLELIIDHLPQLK 603
            ||.  ::|..:..|..         |::...| ..|:...||.  |:.||..||
Mouse   549 WCG--DRCDRQKECPG---------SWQQDHCPPEISEFYPHSGPLRGTTRLTL----------- 591

  Fly   604 ENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFT 668
                |                  |.|......|::|   :|.|..|.
Mouse   592 ----C------------------GSNFYLRPDDVVP---EGTHQITV------------------ 613

  Fly   669 FFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINA 733
                           .:.||                           |:.|...|.|
Mouse   614 ---------------GQSPC---------------------------RLLPKDSSSP-------- 628

  Fly   734 TGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYT 798
             ..||                  :.:||.:        :|..:..|..|.:|.|
Mouse   629 -RPGS------------------LKEFIQE--------LECELEPLVTQAVGTT----------- 655

  Fly   799 SRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEE 863
                                    ||.:||
Mouse   656 ------------------------NISLVI----------------------------------- 661

  Fly   864 QCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINC 928
                                                 ||:.     .||::       |:.||:.
Mouse   662 -------------------------------------TNMP-----AGKHF-------RVEGISV 677

  Fly   929 MPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGG 993
                                                     :|.:.||:|.:....|.|||.:||
Mouse   678 -----------------------------------------QEGFSFVEPVLTSIKPDFGPRAGG 701

  Fly   994 TEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREF-ND 1057
            |.:.:.|:.|:.|:.....:|. ..|::...:..|.:|.|  .||....|:.:....|..|. ..
Mouse   702 TYLTLEGQSLSVGTSRAVLVNG-TQCRLEQVNEEQILCVT--PPGAGTARVPLHLQIGGAEVPGS 763

  Fly  1058 YNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRV 1122
            :.|.|..||.|..:|         || ....|..|.:.|...||..:..: ..::|
Mouse   764 WTFHYKEDPIVLDIS---------PK-CGYSGSHIMIHGQHLTSAWHFTL-SFHDG--------- 808

  Fly  1123 QSDTE-MECASPVVDVDSHVIEAERPILLEY---------------------GFLMDNVLRVQNL 1165
            ||..| .:||...|:.     :..|..|.||                     ||.:.....:...
Mouse   809 QSTVESRQCAGQFVEQ-----QQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRFLPPP 868

  Fly  1166 SKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQ 1230
            |.:.....||.|.      |..||.   ||:     .|........|.:.:|...|.
Mouse   869 SPLRAGLVELKPE------EHSVKV---EYV-----GLGAVADCVTVNMTVGGEVCQ-------- 911

  Fly  1231 LTCRPPSEATATKSMNGPEVIVRIGTSLEY-RIGILSYESSNIILDWGENVIFAV---------- 1284
                        ..:.|..||..:..||:. :.|:    ...:.:|.|.:::..|
Mouse   912 ------------HELRGDVVICPLPPSLQLGKDGV----PLQVCVDGGCHILSQVVRSSPGRASQ 960

  Fly  1285 ----IATIVILLLI---FVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEM 1342
                ||.:|::||:   .|||:...:::..:......:.....||.:....|...|..:|
Mouse   961 RILLIALLVLILLVAVLAVALIFNSRRRKKQLGAHSLSPTTLSDINDTASGAPNHEESSE----- 1020

  Fly  1343 TDLTGDLTSGGIPFLDYRSYAMK------------ILFPN-----HEDHIVLQWERPELLRKEKG 1390
               :.|.||  :|.|...|..::            :|.|:     |.|.::             |
Mouse  1021 ---SRDGTS--VPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVI-------------G 1067

  Fly  1391 LRIFGQL--------IMNKTFL----LLFIRTLESNRYFSMRERV--------NVASLIMVTLQS 1435
            ...||.:        ..|:|..    |..|..::....| :||.:        |:.:||.:.|..
Mouse  1068 KGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAF-LREGLLMRGLHHPNILALIGIMLPP 1131

  Fly  1436 KLEYCTDILKTLL-----GDLI----------EKC----IEGKSHPKLLLRRTESVAEKMLSAWF 1481
            :     .:.:.||     |||:          :.|    :...:||  .||...::
Mouse  1132 E-----GLPRVLLPYMRHGDLLHFIRSPQRVSDHCPGWEVSASTHP--CLRSPVTL--------- 1180

  Fly  1482 TFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASII 1546
                      |...|      .||..|..|...||..|   .|:|:|.:.:.:..|.
Mouse  1181 ----------CPQNP------TVKDLVSFGLQVACGME---YLAEQKFVHRDLAARN-------- 1218

  Fly  1547 QQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATG 1611
                 |    ||   .|:.:|||.|..            :.|.:          ||.|:.:....
Mouse  1219 -----C----ML---DESFTVKVADFG------------LARGV----------LDKEYYSVRQH 1249

  Fly  1612 RVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSIL 1660
            |        .::...:|..|.:||.|.         ...:|.:::|.:|
Mouse  1250 R--------HARLPVKWMALESLQTYR---------FTTKSDVWSFGVL 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	133/494 (27%)
		PSI	522..574	CDD:279745	15/53 (28%)
		PSI	671..>699	CDD:279745	2/27 (7%)
		PSI	830..883	CDD:279745	0/52 (0%)
		IPT_plexin_repeat1	885..977	CDD:238585	9/91 (10%)
		IPT_plexin_repeat2	978..1063	CDD:238584	22/85 (26%)
		IPT	1078..1177	CDD:301692	23/120 (19%)
		IPT_PCSR	1196..>1255	CDD:238337	7/58 (12%)
		Plexin_cytopl	1353..1916	CDD:285529	65/364 (18%)
Mst1r	XP_006511717.1	Sema_RON	29..525	CDD:200540	133/495 (27%)
		PSI	528..570	CDD:214655	14/52 (27%)
		IPT	571..685	CDD:387656	44/404 (11%)
		IPT_plexin_repeat2	686..770	CDD:238584	23/86 (27%)
		IPT	771..864	CDD:214657	24/117 (21%)
		PKc_like	1064..1352	CDD:389743	58/326 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810