DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Plxna3

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_032909.2	Gene:	Plxna3 / 18846	MGIID:	107683	Length:	1872	Species:	Mus musculus

Alignment Length:	1947	Identity:	786/1947 - (40%)
Similarity:	1116/1947 - (57%)	Gaps:	181/1947 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVRSP 132
            ||.|.||.|..:||.||||.|||:::|:|:|.......|||..|:..|    |:..|....|  |
Mouse    31 DTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLV--P 93

  Fly   133 TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSSTVA 190
            .||.||:||||.|..||:||||::||.|....|.::..:       ||.:..| ...|:.:..:.
Mouse    94 VDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGA-QEPDSMAGVIV 157

  Fly   191 FIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVTTG 245
            ....||.:      ::||......|.|   .|.::||.|    :...||      :..||.:...
Mouse   158 EQVQGPSK------LFVGTAVDGKSEY---FPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIP 213

  Fly   246 TRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSH----HSSPKEYITKLVRICQEDSNYYS 306
            :.|.....|.:.|   |:|||.|..|.||||.||....    .:..|.:.:|:||:|..||.:||
Mouse   214 SDTLSLYPAFDIY---YIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYS 275

  Fly   307 YTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNNSA 369
            |.|.|:.|   :..|.::.|||:..|.||...|||:||:...:||||.:||:|:.|  .|...:.
Mouse   276 YVEFPIGC---SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTI 337

  Fly   370 LCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETP 433
            ||:::|.||.....:.|:||:.|.|...|.: ::..:||:.|.|| |..:||||.:|.||||...
Mouse   338 LCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQ-INGNFCGLVLNQPLGGLHV 401

  Fly   434 ITSVPVAMFNTK-LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRD 497
            |..:|:...:|. :.||||.:...::|||:||..|.||||.::.|..|..|.:.:|..||.|.||
Mouse   402 IEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGSPILRD 466

  Fly   498 MQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDP 562
            :.|...:.:||::|:.:||::.|..|..|.:|..|||:.||:||||.|:::|.....| ..|:.|
Mouse   467 LLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGAC-PGASAP 530

  Fly   563 LYWVSYKTGKCTTITSVVPHQLQRTTART-LELIIDHLPQLKENLICAF--TTEDKALFTNATKK 624
             :..:.:..||..: .|.|:.:..|::.. |.:.:.::|.|...:.|:|  .||.:|:...:.:.
Mouse   531 -HGFAEELSKCIQV-RVRPNNVSVTSSGVQLTVAMRNVPDLSVGVSCSFEEVTESEAILLPSGEL 593

  Fly   625 RNGVNCTTPRTDMLPQIEQGKHHFT-----AKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSS 684
            |    |.:|....|..:.:| |..|     ..||:.|  |......||.|::||...||..||.|
Mouse   594 R----CPSPSLQELQTLTRG-HGATHTVRLQLLSMET--GVRFAGVDFVFYNCSALQSCMSCVGS 651

  Fly   685 EFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGG 745
            .:||.||...|.||....| |              |::.|    |..||.|...||   :|:..|
Mouse   652 PYPCHWCKYRHVCTSHPHE-C--------------SFQEGRVHSPEGCPEILPQGD---LLIPVG 698

  Fly   746 TSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQYT-SRSPNLTAT 807
            ..:.:.::...:.| ...|..:.|...::||...:.| :....::.|.:..:.|. ....:....
Mouse   699 VMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELD 763

  Fly   808 FAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGK 872
            |:|:|.|..|:|.|.:...::|:|.....|||:||....::|||||.|.:.|::...|   ...|
Mouse   764 FSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHC---PAPK 825

  Fly   873 TDWLNRSE---ICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQF 934
            ::|::.|:   .|.:|.|....|.|||.||||.:||.|.|||....::  |:|:||:.|...|..
Mouse   826 SNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREV--GLRVAGVRCNSIPTE 888

  Fly   935 YIDTKQIVCTVDSPGEQMYRNGKIVVQIG----DYRGESKEDYEFVDPKILDFNPKFGPTSGGTE 995
            |:..::|||.::.........|...:.:|    |:|.:|::.|.||.|.....:|..||.||||.
Mouse   889 YVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTR 953

  Fly   996 IHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASP-GIIEGRLKMSFDNGPREFNDYN 1059
            :.|:|..|:||||:...|.|. .|:.:..|:...:|.:..|. |..:..:.::.|:.........
Mouse   954 LTISGISLDAGSRVTVIIRDG-ECQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVI 1017

  Fly  1060 FKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQS 1124
            :.|..||||.|:....|        |..|...|:|:||...::|.|.:...|.|....:.|:|.:
Mouse  1018 YTYTQDPTVTHLEPTWS--------IINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVIN 1074

  Fly  1125 DTEMECASPVVDVDSHV---IEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEE 1186
            ||.|.|.:|.:.: .|.   .:.|.|.  |:|||:|:|...::|::   :.|..||:|.   ||.
Mouse  1075 DTAMLCKAPGIFL-GHPQPRAQGEHPD--EFGFLLDHVQAARSLNR---SSFTYYPDPS---FEP 1130

  Fly  1187 -------RVKYFKSEYLTINGRNLDRACKES---DVEVKIGNGFCNITSLSRQQLTCRPPSEATA 1241
                   .||  ...::.:.|:||..|...|   :..|.||...|.:| :|..||.|..||:.
Mouse  1131 LGPSGVLDVK--PGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALT-VSDTQLLCDSPSQT-- 1190

  Fly  1242 TKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV---ILLLIFVALLVAYK 1303
                ....|:|.:| .||:.:|.|...:...:      .:.|::....   :|||....:|||||
Mouse  1191 ----GRQPVMVLVG-GLEFWLGTLHITADRAL------TLPAMVGLAAGGGLLLLAITVVLVAYK 1244

  Fly  1304 KKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILF 1368
            :|:.::.|.|:.:|.|||.||.|||.|||||||||||::.:||..:....|||||||:||:::||
Mouse  1245 RKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLF 1309

  Fly  1369 PNHEDHIVL-QWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVT 1432
            |..|.|.|| :.:.|.  ..||.||:||||:.::.|||.||.|||:...||||:|..||||.||.
Mouse  1310 PGIEAHPVLKELDTPP--NVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVA 1372

  Fly  1433 LQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPL 1497
            |||:|:|.|.:||.||.|||||.:|.|:|||||||||||||||||:.||||||:|||||||||||
Mouse  1373 LQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPL 1437

  Fly  1498 YMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHT 1562
            ::|:.|:|.|::|||:||.|.||||||||:|||||.||::.:.::.       .|...:    .:
Mouse  1438 FLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHC-------VCPESE----GS 1491

  Fly  1563 ENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESE 1627
            ..|.||||:||:|.|.|:|.|:|:|:.||.||||:.:|:|||||.|...|:||.|||:|:|.|.:
Mouse  1492 AQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECD 1556

  Fly  1628 WKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTS-----SSPTFSR 1687
            ||::|:|.||.|.||:.::|||||.|.||.:       .|..: |.::|:|.|     |||...|
Mouse  1557 WKRVNSLAHYQVTDGSLVALVPKQVSAYNMA-------NSFTF-TRSLSRYESLLRAASSPDSLR 1613

  Fly  1688 AGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIF 1752
            :.:|:.....|.|.:.||||::||....:||:|.:|:||||||||||||||||||||||||||:|
Mouse  1614 SRAPMLTPDQEAGTKLWHLVRNHDHTDHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVF 1678

  Fly  1753 STAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSN 1817
            |||||||||||||||||||||:||....|:||:|.||||||.||||||||:||||.|||||||::
Mouse  1679 STAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNS 1743

  Fly  1818 IVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMN 1882
            |.|:||||||||||||||||:|||||||||:|||||||||.|:.||:||||||..|:.||||||:
Mouse  1744 ITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMD 1808

  Fly  1883 AMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMSS 1944
            |.|.|:||||..:||...||.|||.|..||.:::..:|:.|...:|.:|..||||:..::||
Mouse  1809 AYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSS 1870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	169/473 (36%)
		PSI	522..574	CDD:279745	18/51 (35%)
		PSI	671..>699	CDD:279745	13/27 (48%)
		PSI	830..883	CDD:279745	17/55 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	978..1063	CDD:238584	23/85 (27%)
		IPT	1078..1177	CDD:301692	28/101 (28%)
		IPT_PCSR	1196..>1255	CDD:238337	18/61 (30%)
		Plexin_cytopl	1353..1916	CDD:285529	344/568 (61%)
Plxna3	NP_032909.2	Sema_plexin_A3	22..490	CDD:200534	171/477 (36%)
		PSI	491..>531	CDD:279745	17/41 (41%)
		PSI	638..685	CDD:214655	19/61 (31%)
		PSI	789..830	CDD:214655	15/43 (35%)
		IPT_plexin_repeat1	841..935	CDD:238585	33/95 (35%)
		IPT_plexin_repeat2	936..1022	CDD:238584	24/86 (28%)
		IPT_plexin_repeat3	1024..1124	CDD:238586	33/113 (29%)
		IPT_PCSR	1126..1209	CDD:238337	27/95 (28%)
		Plexin_cytopl	1295..1842	CDD:285529	344/567 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1362	1.000	Inparanoid score	I132
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm43935
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860