DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and Plxna2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_006497303.1	Gene:	Plxna2 / 18845	MGIID:	107684	Length:	1901	Species:	Mus musculus

Alignment Length:	1972	Identity:	812/1972 - (41%)
Similarity:	1152/1972 - (58%)	Gaps:	216/1972 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTD 134
            |...|||.|...||.|:||.:||:|:|:.:|.:....||||:.|:..|  .::..|.:.|.:.|:
Mouse    47 DWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTN 111

  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD---------AVVAND 183
            |.||:|:||.:.:||:|||||:||.|.:..|.::.|:       ||.:..         .:|.::
Mouse   112 NVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSE 176

  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAV 242
            .....                :::|........|   .|.::||.|    |.:.|  :::.|..|
Mouse   177 GEDGK----------------LFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFV 222

  Fly   243 TTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLKHS-----HHSSPKEYITKLVRICQED 301
            ::..:...::.|..::| :.|:|||:|..|.||||.|.:..     :.:....|.:::||:|::|
Mouse   223 SSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDD 287

  Fly   302 SNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG--NTP 364
            ..::||..:|..|   .:.|.::.|:||.:|.||...|||:..||..:|||||:||||:.  :.|
Mouse   288 PKFHSYVSLPFGC---TRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHP 349

  Fly   365 TNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGLDVNSP 427
            .::||||.:.:::|..:..:.::||::|.|...|:: :...:.|  ||... |.::|||||:|.|
Mouse   350 PDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQC--TKAPVPIDDNFCGLDINQP 412

  Fly   428 LGGETPITSVPVAMFNT---KLTSVAATSTSGYTVVFVGTSDGFLKKVVIES---SSIANEYASF 486
            |||.||:..  :.::.|   :|||||:...:||:||||||..|.|||:..:.   ..:..|..|.
Mouse   413 LGGSTPVEG--LTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSV 475

  Fly   487 AVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSP 551
            ..| ||.|.|||.|....||:||||:.:|::|.|..|..|.|||:||.:.||:||||:|.|.||.
Mouse   476 FKD-GSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSR 539

  Fly   552 RSNCQD--DANDPLYWVSYKTGKCTTITSVVPHQLQRTT-ARTLELIIDHLPQLKENLICAFTTE 613
            |..||.  :||.    .:....:|.:: .|.|:.:..:. :|.|.|:::..|.|.|.:.||
Mouse   540 RDKCQRAWEANR----FAASISQCMSL-EVHPNSISVSDHSRLLSLVVNDAPNLSEGIACA---- 595

  Fly   614 DKALFTNATKKRNGVN-----CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDC 672
                |.|.|:....|:     |.:|....:|.|...:..|..:|.:|:: .|...|||:|.|::|
Mouse   596 ----FGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNC 656

  Fly   673 STHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINA 733
            |.|..|..||:|.|.|.||...:.||||.. .|              |::.|    ...||.:..
Mouse   657 SAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TC--------------SFQEGRINVSEDCPQLVP 706

  Fly   734 TGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQ 796
            |   .|:|:..|..|.|.:|...:.| ...|..:.|..:|:|.|..:.| :....::.|.:..:|
Mouse   707 T---EEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQ 768

  Fly   797 YTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCE 860
            |.... .||...|||:|.|:..:|||.::.|.:|:|....:|||:||....|:.|||||....|.
Mouse   769 YDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCT 833

  Fly   861 VEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAG 925
            :.:.|........||.:.:..|.||:|......:||.||||.:||.|:|||.::::|...|::||
Mouse   834 LHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAG 898

  Fly   926 INCMPFPQFYIDTKQIVCTVDSPGEQMY--RNGKIVVQIGDYRGE----SKEDYEFVDPKILDFN 984
            :.|.|.|..||..:||||.:   |..:.  .:|.:.:.||:.:.|    |.:.|.||:|.:|..:
Mouse   899 VPCTPIPGEYIIAEQIVCEM---GHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLS 960

  Fly   985 PKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAIC-RTSASPGIIEGRLKMSF 1048
            |..||.||||.:.|||.:|.|||.:...:.:. .|:......::.:| ...:|.|:....:.:|.
Mouse   961 PIRGPESGGTMVTITGHYLGAGSSVAVYLGNQ-TCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSV 1024

  Fly  1049 DNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNIYVVYN 1112
            |.. |..:...|:|:.||.|:.:.         |: .|.:|...:::||.....||.|.:.|.:|
Mouse  1025 DRA-RVDSSLQFEYIDDPRVQRIE---------PEWSITSGHTPLTITGFNLDVIQEPRVRVKFN 1079

  Fly  1113 GEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFEL 1175
            |:...:.|.|.:.|.:.|.:|.:..|..  :...|||.  |:|||.:|   ||:|...::..|..
Mouse  1080 GKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPD--EFGFLFNN---VQSLLIYNDTKFIY 1139

  Fly  1176 YPNPEY------FIFEERVKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNITSLSR 1228
            ||||.:      .|.:::    ....:.:.|:||   |..:      :..|.||...|.:| :|.
Mouse  1140 YPNPTFELLSPTGILDQK----PGSPIILKGKNL---CPPASGGAKLNYTVMIGETPCTVT-VSE 1196

  Fly  1229 QQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILL 1292
            .||.|.||       ::.|. :|:|.:| .:.:..|.:|..|.:::.   ...|.::.|...:||
Mouse  1197 TQLLCEPP-------NLTGQHKVMVHVG-GMVFSPGSVSVISDSLLT---LPAIISIAAGGSLLL 1250

  Fly  1293 LIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFL 1357
            :|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...|||:|
Mouse  1251 IIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYL 1315

  Fly  1358 DYRSYAMKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRTLESNR 1415
            |||:|||::|||..|||.||:    ||       ...||.|::|.|||.||.|||.||||||..|
Mouse  1316 DYRTYAMRVLFPGIEDHPVLR----ELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQR 1376

  Fly  1416 YFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAW 1480
            .||||:|.|||||||..||.:|||.||:||.||.|||:|.:|.|:|||||||||||||||||:.|
Mouse  1377 SFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNW 1441

  Fly  1481 FTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASI 1545
            |.|||:|||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.|:      |.::
Mouse  1442 FAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIE------YKTL 1500

  Fly  1546 IQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDL------- 1603
            |   :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:||
Mouse  1501 I---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLATHPFHP 1560

  Fly  1604 EWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSH 1668
            |||.|...||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|.
Mouse  1561 EWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASA 1618

  Fly  1669 KYETLNISKYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEI 1728
            .....:||:|.||     ||...|:..|:.....|:|::.|||||:||...||||:|.:|:||||
Mouse  1619 SISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEI 1683

  Fly  1729 YLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSN 1793
            ||||||||||||||||||||||:|||.||||||||||||||||||:||..|.|.|.:|.||||||
Mouse  1684 YLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSN 1748

  Fly  1794 SLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPE 1858
            .||||||||:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.
Mouse  1749 CLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPS 1813

  Fly  1859 YRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEED 1923
            |:.||:|||.||..:..||||||||.|||:||||.||||...||:|:|:|..||:|:|...||:|
Mouse  1814 YKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQD 1878

  Fly  1924 EFSQKQRLAFKLEQVHNIMSSE 1945
            |.:::||||:|:|.:.|.||.|
Mouse  1879 EQARRQRLAYKVEHLINAMSIE 1900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	160/484 (33%)
		PSI	522..574	CDD:279745	22/53 (42%)
		PSI	671..>699	CDD:279745	12/27 (44%)
		PSI	830..883	CDD:279745	16/52 (31%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	978..1063	CDD:238584	24/85 (28%)
		IPT	1078..1177	CDD:301692	29/101 (29%)
		IPT_PCSR	1196..>1255	CDD:238337	18/65 (28%)
		Plexin_cytopl	1353..1916	CDD:285529	361/581 (62%)
Plxna2	XP_006497303.1	Sema_plexin_A2	38..552	CDD:200533	184/535 (34%)
		TIG_plexin	566..654	CDD:375449	25/95 (26%)
		PSI	655..702	CDD:366642	18/61 (30%)
		TIG_2	708..802	CDD:375492	27/93 (29%)
		PSI	806..855	CDD:366642	15/48 (31%)
		IPT_plexin_repeat1	858..953	CDD:238585	35/97 (36%)
		IPT_plexin_repeat2	954..1037	CDD:238584	24/84 (29%)
		IPT_plexin_repeat3	1041..1141	CDD:238586	31/113 (27%)
		TIG	1143..1227	CDD:366832	22/99 (22%)
		Plexin_cytopl	1311..1870	CDD:369821	360/580 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	710	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1362	1.000	Inparanoid score	I132
Isobase	1	0.950	-	0	Normalized mean entropy	S4424
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm43935
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3977
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.800