DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and Met

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_032617.2 Gene:Met / 17295 MGIID:96969 Length:1379 Species:Mus musculus


Alignment Length:1784 Identity:355/1784 - (19%)
Similarity:590/1784 - (33%) Gaps:662/1784 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 APIKNAKNLNS--TITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLS-PDLELSETVKTGPQN 114
            |.:|:..|:|.  .:.|..| :|.:.::::.  ...:::|..|.:|.|: .||:.....||||..
Mouse    29 ALVKSEMNVNMKYQLPNFTA-ETPIQNVVLH--GHHIYLGATNYIYVLNDKDLQKVSEFKTGPVL 90

  Fly   115 DSVEC-SILDCPLNAVRSP---TDNYNKVLLIDR-ATSRLIACGSLFQGTCTVRNL--QNVSIIE 172
            :..:| ...||...|..|.   .||.|..||:|. ...:||:|||:.:|||....|  .|.:.|:
Mouse    91 EHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQ 155

  Fly   173 HEV-------------PDAVV----ANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSE 220
            .||             ||.||    |....|....||.           .:||.|..::.|....
Mouse   156 SEVHCMFSPEEESGQCPDCVVSALGAKVLLSEKDRFIN-----------FFVGNTINSSYPPGYS 209

  Fly   221 IPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHS 285
            :.:::.|.|::|   |.....:|..:...:....:::|.:.|::.|.|..|.||||.|   ....
Mouse   210 LHSISVRRLKET---QDGFKFLTDQSYIDVLPEFQDSYPIKYIHAFESNHFIYFLTVQ---KETL 268

  Fly   286 SPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTK------FNLVQAGFLGKPSSDLAQSLG 344
            ..:.:.|:::|.|..||..:||.|:|:|||...:...:      ||::||.::.||.::||:.:|
Mouse   269 DAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIG 333

  Fly   345 ISIQDDVLFAVF--SKGEGNTPTNNSALCIYSLKSIRRKFMQ----------------NIKSCFN 391
            .|..||:||.||  ||.:...|.|.||:|.:.:|.:...|.:                |.:.|||
Mouse   334 ASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFN 398

  Fly   392 GSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSV--PVAMFNTKLTSVAATST 454
            .:.:|.      |..|     :...:::           .|..|:.  .|.:|..:|..|..||.
Mouse   399 RTLLRN------SSGC-----EARSDEY-----------RTEFTTALQRVDLFMGRLNQVLLTSI 441

  Fly   455 SGY-----TVVFVGTSDGFLKKVVIESSSIANEYASFAVD---LGSEINRDMQFDNQNLYIYVMS 511
            |.:     |:..:|||:|...:||:..::....:.:|.:|   :..|:..:.. .|||.|..|::
Mouse   442 STFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHP-SNQNGYTLVVT 505

  Fly   512 KTKVSKVKV--FDCSDYKTCGDCLGARDPY---CGWCSLENKCSPRSNCQDDANDPLYWVSYKTG 571
            ..|::|:.:  ..|..:::|..||.|  ||   ||||                            
Mouse   506 GKKITKIPLNGLGCGHFQSCSQCLSA--PYFIQCGWC---------------------------- 540

  Fly   572 KCTTITSVVPHQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTD 636
                                                                             
Mouse   541 ----------------------------------------------------------------- 540

  Fly   637 MLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDT 701
                                                  |:.|.|...                  
Mouse   541 --------------------------------------HNQCVRFDE------------------ 549

  Fly   702 AENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRF 766
                                      ||:              ||                    
Mouse   550 --------------------------CPS--------------GT-------------------- 554

  Fly   767 VCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRC 831
                                                                             
Mouse   555 ----------------------------------------------------------------- 554

  Fly   832 REMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGP 896
                                                       |  ..||| .|.::...|.:.|
Mouse   555 -------------------------------------------W--TQEIC-LPAVYKVFPTSAP 573

  Fly   897 WEGGTNITIRGINLG---KNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKI 958
            .||||.:||.|.:.|   .|..|:.....:.|............|..:.|||   |..|..:..:
Mouse   574 LEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTV---GPAMSEHFNV 635

  Fly   959 VVQIGDYRGESK-EDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKIL 1022
            .|.|.:.|..:: ..:.:|||.|...:|::||.:|||.:.:|||:||:|:....||... .|.:.
Mouse   636 SVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGK-TCTLK 699

  Fly  1023 STDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPA 1087
            |...|...|.|.|.....|..:|:..|...||.:  :|.|..||.|.        :|...|...:
Mouse   700 SVSDSILECYTPAQTTSDEFPVKLKIDLANRETS--SFSYREDPVVY--------EIHPTKSFIS 754

  Fly  1088 GGIRISVTGTQFTSIQNPNIYVVYN--GEMYASPCRVQSDTEME-CASPVVDVDSHVIEAERPIL 1149
            ||..|:..|....|:..|.:.:..:  |..|...|:.:|::|:. |.:|.:    ..:..:.|:.
Mouse   755 GGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSL----KQLGLQLPLK 815

  Fly  1150 LEYGFLMDNVLRVQ-NLSKVHNNHFELYPNPEYF-IFEERVKYFKSEYLTINGRNLDRACKESDV 1212
            .:..||:|.:|... :|:.|||..||.:..|... |..|.|       :.|.|.|:|....:.:|
Mouse   816 TKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISIGNENV-------VEIKGNNIDPEAVKGEV 873

  Fly  1213 EVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSL--EYRIGILSYESSNIILD 1275
             :|:||..|.........:.|..||:            ::::.:.|  |::..:.|.....:|:.
Mouse   874 -LKVGNQSCESLHWHSGAVLCTVPSD------------LLKLNSELNIEWKQAVSSTVLGKVIVQ 925

  Fly  1276 WGEN----VIFAVIATIVILLLIFVALLVAYKKKSSESSRVLR-NMQEQMDILELRVAA------ 1329
            ..:|    :|.||..::|:|||..:.|.:..:|.....|.::| :.:.....|:..|:|      
Mouse   926 PDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPT 990

  Fly  1330 ---------ECKEAFAE--------------LQTEMTDLTGDLTSG----GIPFLDYRSYAMKIL 1367
                     :.:..|.|              :|..:|||:..||||    ..|.|          
Mouse   991 TEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLL---------- 1045

  Fly  1368 FPNHEDHIVLQWERPELLRKEKGLRI--------FGQLIMNKTFLLLFIRTL------------- 1411
              .:..||.|....|||::..:.:.|        |.::|....|..::..||             
Mouse  1046 --QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVK 1108

  Fly  1412 ESNRYFSMRE---------------RVNVASLIMVTLQSK------LEYCTDILKTLLGDLIEKC 1455
            ..||...:.|               ..||.||:.:.|:|:      |.|...      ||| ...
Mouse  1109 SLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH------GDL-RNF 1166

  Fly  1456 IEGKSH----------------------PKLLLRRTESVAEKMLSAWFTFLLYKF--LKECAGEP 1496
            |..::|                      .|..:.|..:....||...||..:..|  .::...:.
Mouse  1167 IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKE 1231

  Fly  1497 LYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQS--------------------IDFRPMNV 1541
            .|.:......::   ||.....|   ||..:|...:|                    .|....::
Mouse  1232 YYSVHNKTGAKL---PVKWMALE---SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDI 1290

  Fly  1542 YASIIQ-----QPIFCNN-------------LDMLPSHTENVS-VKVLDCDTIGQ---------V 1578
            ...::|     ||.:|.:             .:|.||.:|.|| :..:....||:         |
Mouse  1291 TIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYV 1355

  Fly  1579 KEKCLETIYRNIPSSQRPRKDDLDLEWRT 1607
            ..||:......:||     :|::|.|..|
Mouse  1356 NVKCVAPYPSLLPS-----QDNIDGEGNT 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 131/503 (26%)
PSI 522..574 CDD:279745 11/54 (20%)
PSI 671..>699 CDD:279745 3/27 (11%)
PSI 830..883 CDD:279745 3/52 (6%)
IPT_plexin_repeat1 885..977 CDD:238585 23/95 (24%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/84 (33%)
IPT 1078..1177 CDD:301692 26/102 (25%)
IPT_PCSR 1196..>1255 CDD:238337 12/58 (21%)
Plexin_cytopl 1353..1916 CDD:285529 67/369 (18%)
MetNP_032617.2 Sema 25..515 CDD:387663 138/528 (26%)
PSI 518..560 CDD:214655 20/362 (6%)
IPT_plexin_repeat1 562..655 CDD:238585 23/95 (24%)
IPT_plexin_repeat2 656..739 CDD:238584 29/85 (34%)
IPT 741..836 CDD:387656 23/106 (22%)
IPT_PCSR 838..917 CDD:238337 20/98 (20%)
PTKc_Met_Ron 1080..1341 CDD:270649 46/273 (17%)
Interaction with RANBP9. /evidence=ECO:0000250 1210..1379 33/179 (18%)
Interaction with MUC20. /evidence=ECO:0000250 1318..1357 9/38 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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