DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexA and PLXNC1

DIOPT Version :9

Sequence 1:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster
Sequence 2:NP_005752.1 Gene:PLXNC1 / 10154 HGNCID:9106 Length:1568 Species:Homo sapiens


Alignment Length:1953 Identity:507/1953 - (25%)
Similarity:790/1953 - (40%) Gaps:556/1953 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 VFVGGVNRLYQLSPDLE--LSETVKTGPQNDSVECSILDCPLNAVRSPTDNYNKVLLIDR----A 145
            |||...:.|.||...||  ||...:....|.:...|:  .|....| |..:::|:||..|    .
Human    57 VFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSL--APPARPR-PGSSFSKLLLPYREGAAG 118

  Fly   146 TSRLIACGSLF-QGTCTVRNLQNVSIIEHEVPDAVVANDANSSTVAFIAPGPPQHPVTNVMY--- 206
            ...|:..|..| :|.|.||.|.|:|           .|...:.|.  :....||.....|:|   
Human   119 LGGLLLTGWTFDRGACEVRPLGNLS-----------RNSLRNGTE--VVSCHPQGSTAGVVYRAG 170

  Fly   207 --------VGVTYTNNSPYR-------------------SEIPAVASRSLEKTKMFQIASSAVTT 244
                    |..||....|..                   :|..::|::.|.:.|:.:.|      
Human   171 RNNRWYLAVAATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCEGA------ 229

  Fly   245 GTRTFINSYA--RETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSY 307
            |:..|::::.  ...||..|.|.::|...:.:                 ..:.||.|.       
Human   230 GSLHFVDAFLWNGSIYFPYYPYNYTSGAATGW-----------------PSMARIAQS------- 270

  Fly   308 TEI------PVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFS--KGEG--- 361
            ||:      .::|......|.:..|         ||.|.::|      ||...|||  .|||   
Human   271 TEVLFQGQASLDCGHGHPDGRRLLL---------SSSLVEAL------DVWAGVFSAAAGEGQER 320

  Fly   362 NTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNS 426
            .:|| .:|||::.:..|:.:           :.....||.:....|                   
Human   321 RSPT-TTALCLFRMSEIQAR-----------AKRVSWDFKTAESHC------------------- 354

  Fly   427 PLGGETPITSVPVA---MFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAV 488
             ..|:.|....|:|   :.::.||||..|.....||:|:||.||.|.||::..:..:|     ..
Human   355 -KEGDQPERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSN-----CP 413

  Fly   489 DLGSEINRD-------MQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLE 546
            ::..||..:       :....:|:|||:.:..:|.:::|.:|:.:|:|.:||.|.||:||||...
Human   414 EVIYEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSL 478

  Fly   547 NKCSPRSNCQDDANDPLYWVSYKTG--KCTTITSVVPHQLQRTTARTLELIIDHLPQLKENLICA 609
            .:|:.:.:|....|.. .|:...:|  ||..| .::....::|   |:.::....|:..:   |.
Human   479 QRCTFQGDCVHSENLE-NWLDISSGAKKCPKI-QIIRSSKEKT---TVTMVGSFSPRHSK---CM 535

  Fly   610 FTTED--KALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDC 672
            ....|  :.|..|.::......|:.|        .:..:...:.::|....|...:|..|.|.:|
Human   536 VKNVDSSRELCQNKSQPNRTCTCSIP--------TRATYKDVSVVNVMFSFGSWNLSDRFNFTNC 592

  Fly   673 STHSSCTRCVSSEFPCDWCVEAHRCTH-----DTAENCRND----ILVTGVSRIG-PSYRSGPGF 727
            |:...|..||  |..|.||..|.||.|     |.::..||.    :.|...|..| |....|   
Human   593 SSLKECPACV--ETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPKENKG--- 652

  Fly   728 CPTINATGDGSEVLVAGGTSKSIK-VKVHIIGQ---FIVQTRFVCQFNIEGRVTSLNAQLLGDTI 788
                |.|....:|...    |||: .||..:|:   .:....|....||        ..:|..|.
Human   653 ----NRTNQALQVFYI----KSIEPQKVSTLGKSNVIVTGANFTRASNI--------TMILKGTS 701

  Fly   789 YCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWC 853
            .||....|.                 |..|::.|....:....:||.|   :|:    :::.|.|
Human   702 TCDKDVIQV-----------------SHVLNDTHMKFSLPSSRKEMKD---VCI----QFDGGNC 742

  Fly   854 SSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIY 918
            ||.              |...::      ..|......|.|....||.|||:.|.|.....|.|.
Human   743 SSV--------------GSLSYI------ALPHCSLIFPATTWISGGQNITMMGRNFDVIDNLII 787

  Fly   919 SGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYRGESKEDYEFVDPKILDF 983
            |......||...:           |                  :..|.|       |:.|.:   
Human   788 SHELKGNINVSEY-----------C------------------VATYCG-------FLAPSL--- 813

  Fly   984 NPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSF 1048
                  .|.....::|.|     .|:|   :.:|.|..|                          
Human   814 ------KSSKVRTNVTVK-----LRVQ---DTYLDCGTL-------------------------- 838

  Fly  1049 DNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNG 1113
                        :|..||                               :||..           
Human   839 ------------QYREDP-------------------------------RFTGY----------- 849

  Fly  1114 EMYASPCRVQS--DTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELY 1176
                   ||:|  |||:|                              :::|.    .|::|.: 
Human   850 -------RVESEVDTELE------------------------------VKIQK----ENDNFNI- 872

  Fly  1177 PNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNG-----FCNITSLSRQQ----LT 1232
                                           .:.|:|:.:.:|     .|:..:::|.|    :.
Human   873 -------------------------------SKKDIEITLFHGENGQLNCSFENITRNQDLTTIL 906

  Fly  1233 CRPPSEATATKSMN-GPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFV 1296
            |:.....||:...| ..:|.|::| :||     |..|..::...|    .|.::..::::::||.
Human   907 CKIKGIKTASTIANSSKKVRVKLG-NLE-----LYVEQESVPSTW----YFLIVLPVLLVIVIFA 961

  Fly  1297 ALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRS 1361
            |:.|. :.||.|.|   |...:|:::||..:..|.::.|||||.:..|:....  |.:|||||:.
Human   962 AVGVT-RHKSKELS---RKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSF--GTVPFLDYKH 1020

  Fly  1362 YAMKILFPNHE--DHIVLQ-WERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERV 1423
            :|::..||...  .||..: ....:...|.:.|.....||.||:||:..|.|||..:.||:::|.
Human  1021 FALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRC 1085

  Fly  1424 NVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKF 1488
            ..||.:.:.||:||.|.|.||:.|..||:|:|  ....|||:|||||||.||:|:.|.:..|..|
Human  1086 LFASFLTIALQTKLVYLTSILEVLTRDLMEQC--SNMQPKLMLRRTESVVEKLLTNWMSVCLSGF 1148

  Fly  1489 LKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCN 1553
            |:|..|||.|:|...:..:::|||||..|.:|.|:|:|:.|:.|..:|      :::....:|  
Human  1149 LRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEF------STVALNVVF-- 1205

  Fly  1554 NLDMLPSH-----TENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRV 1613
              :.:|.:     ..|:||.|||||||||.|||..:.......|....:.:::.||.:.|...:.
Human  1206 --EKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKE 1268

  Fly  1614 ILYDEDVTSKT---ESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNI 1675
            :|   |:.|.:   |....||||:.||.:.:|:.:.:..|   |.||:  ||.     :|...:.
Human  1269 LL---DIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKK---IANFT--SDV-----EYSDDHC 1320

  Fly  1676 SKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTL 1740
            ......|..|...          .|.|  |..||...            |.|:|||:||:||..:
Human  1321 HLILPDSEAFQDV----------QGKR--HRGKHKFK------------VKEMYLTKLLSTKVAI 1361

  Fly  1741 QKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIK 1805
            ...::.||.:|:|..:  |..|.||||.|||||.||:...||||:|||.||:||||||||||::|
Human  1362 HSVLEKLFRSIWSLPN--SRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILK 1424

  Fly  1806 NPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDI 1870
            ||.|||||.|:..:|.||||:||.|||:.|.::.:|||::|::|||||||||.|::.|..||:.|
Human  1425 NPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAI 1489

  Fly  1871 RDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEED---EFSQKQRLA 1932
            ||:.|:|..:|...|.:||:.|..|||...||.|:|.|.|||.:::...||.:   |.:|||.|.
Human  1490 RDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLH 1554

  Fly  1933 FKL 1935
            .|:
Human  1555 VKV 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 107/492 (22%)
PSI 522..574 CDD:279745 18/53 (34%)
PSI 671..>699 CDD:279745 12/27 (44%)
PSI 830..883 CDD:279745 9/52 (17%)
IPT_plexin_repeat1 885..977 CDD:238585 19/91 (21%)
IPT_plexin_repeat2 978..1063 CDD:238584 9/84 (11%)
IPT 1078..1177 CDD:301692 12/100 (12%)
IPT_PCSR 1196..>1255 CDD:238337 12/68 (18%)
Plexin_cytopl 1353..1916 CDD:285529 225/573 (39%)
PLXNC1NP_005752.1 Sema_plexin_C1 44..453 CDD:200507 107/493 (22%)
PSI 454..507 CDD:279745 18/53 (34%)
PSI 591..635 CDD:214655 16/45 (36%)
TIG 664..750 CDD:280079 26/135 (19%)
IPT 753..841 CDD:214657 28/178 (16%)
Plexin_cytopl 1012..1535 CDD:285529 225/573 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D90434at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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