DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxnb1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_012817153.2	Gene:	plxnb1 / 100498269	XenbaseID:	XB-GENE-856606	Length:	2221	Species:	Xenopus tropicalis

Alignment Length:	2289	Identity:	710/2289 - (31%)
Similarity:	1042/2289 - (45%)	Gaps:	510/2289 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LNSTITNVAAF--DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC---S 120
            ::.||..||..  :|..|||.:|..||.::||..|.||||:.:|.:...|:|||..||.||   .
Frog    21 VSGTIPYVAFVQNNTIFNHLTLDANTGTLYVGATNSLYQLTENLAVEMLVRTGPVWDSKECLPPV 85

  Fly   121 ILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII----EHEV-PDAVV 180
            ..|||   ....|:|:||:||:..:...||.|||::||.|..|.|.:|..:    |..| ...|.
Frog    86 STDCP---QAQNTNNHNKLLLVVPSKRELIVCGSVYQGICESRRLGSVQTVLFRPERPVDTQYVA 147

  Fly   181 ANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAV--- 242
            |||.|.:||..:|......|   :::||..||:..  ...||.:.:|:||.....::.|.:|
Frog   148 ANDPNVTTVGLVALSKDGSP---LLFVGRGYTSKG--AGGIPPITTRNLEVGGDSEMESHSVFSY 207

  Fly   243 -TTGTRTFINSYARETYFVNYVYGFSSERFSYFL--TTQLKHSHHSSPKEYITKLVRICQEDSNY 304
             .|.....:...:.  |..:::..|:.:...|||  ...||    |..:||.|.:.|||..||:|
Frog   208 EDTAKLAVVGRLSE--YNHHFIKAFTHKSNVYFLFYRRDLK----SQSREYKTYISRICPNDSHY 266

  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPT--NN 367
            |||.|:|:.|.:..:   .:||:||.::.:|...||:.: :....|||||.||:.:..:..  ..
Frog   267 YSYVELPLSCRTKDK---SYNLLQAAYVTQPGERLAKGV-LKTDGDVLFAAFSQWQAASGKVGEE 327

  Fly   368 SALCIYSLKSIRRKFMQNIKSCFNGSGM----RGLDFISPSMP--CVLTKLQTIGEDFCGLD-VN 425
            |.||:||:..|.|...|...:|:...|.    |.:.:|...:.  ||.....|:....||.| ..
Frog   328 SGLCLYSMDLIDRLINQTRDTCYTKDGKAEDGREVAYIEYDVKSNCVQLPSDTLDAYPCGSDHTP 392

  Fly   426 SPLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVD 489
            ||:..:.|:.:.|: ....|:.|::|......:|:.|:|.|.|:|.||.:.......:|:|....
Frog   393 SPMASKDPLEATPLFESATTRFTAIAVHVEGEHTIAFIGDSKGYLNKVYLGGEQDTRQYSSVGTQ 457

  Fly   490 LGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSN 554
            ..|.:..|:.||.:..::|:::::.|.||.:.:||.:..|..||.|.|||||||.|..|||....
Frog   458 SNSAVLPDLLFDQEEKHLYILTQSTVMKVPLSECSTFTDCDSCLSAGDPYCGWCVLYGKCSRSYE 522

  Fly   555 C-QDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQL--KENLICAFTTEDKA 616
            | :....:...|...:..:|..:.|:.|..:.:...|.:.|.|..||.|  :|:..|.|  ||
Frog   523 CLRSGQKNQWLWAYDQNQQCLAVQSLSPANISKEEKRNIFLSIPDLPALEHEESYSCFF--ED-- 583

  Fly   617 LFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCST------H 675
            ..:.|..:..||.|.:|.....|.|:.|..|...||.:|. ....:.||:|||:||..      :
Frog   584 FESRAVIRDTGVMCPSPDPSKTPAIKPGTDHVQVKLVLRF-GEVTICSTEFTFYDCMAVAQLYKN 647

  Fly   676 SSCTRCVSSEFPCDWCVEAHRCTHDTA---------------------------ENCRNDILVTG 713
            :.|..||||::.|:||::.|.|||...                           |.....:|.|.
Frog   648 APCRGCVSSDWGCNWCIQQHHCTHKATCEEGTIIYNKLTQIPFLDPTIPPEVPFELTTTVVLSTV 712

  Fly   714 VSRIGPSY--------------------------------------------------------- 721
            ||...||.
Frog   713 VSETSPSEAPVTTASPTPSTTTFTTIPETSPTTFPPTTIPTTLPVTTPATTPTTVLQPDPSTAIL 777

  Fly   722 --------------------RSGPGFCPT------------------------------------ 730
                                .|.|...||
Frog   778 DLATEDTIPDITMEPSTEEPTSRPTTIPTTMFVDIATSPPVTDNEYEEFTEESVLPELVTTEGST 842

  Fly   731 ------------------------------------INATG------------------------ 735
                                                :.:||
Frog   843 TFYMTTTPVPVPPPTTPETQEEHPWVPTILHPTQEELTSTGQPITTPNQASSVSSLPGSPDEFHS 907

  Fly   736 --------------DGSE---------------------------VLVAG-----GTSKS----- 749
                          ||:|                           .:::|     |.|.|
Frog   908 EIPFSEEPPTVPSEDGTEENLDQTEADDWADSASMDNDTSSFSASTILSGDGESDGVSPSFPGIL 972

  Fly   750 -------------------------------------------IKVKVHIIGQFI-----VQTRF 766
                                                       ::.|:.::|:..     .|..:
Frog   973 EPDLDYQFDSPGLFEMDEEELIWGPEACPCVESIQSASLLPVNVERKITLVGKNFHHYQDQQMDY 1037

  Fly   767 VCQFNIEGRVTSLNAQLLGDT-------IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNI 824
            .|...:|||....:|.|..|.       |.|...::.|::......|...|.......:|:..::
Frog  1038 DCVLLLEGRTVVTDAVLELDPEEESKYYITCQLHQYSYSALQLEFNAMVFVRIQSYLRVDSAEDL 1102

  Fly   825 HVVIYRCREMADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIH 888
            :|.:|.|......|..|.....||||.||..:: .|..:|.|.:..||         .||.|.||
Frog  1103 YVTLYNCSVGHPDCSRCQTADPKYNCVWCGGSHPNCMYQETCKEKVEG---------TCPAPLIH 1158

  Fly   889 TFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY 953
            :.:|.:||.||||.|||.|.|||:...||...|.:|||.|......|..:.:|||.:.|...:
Frog  1159 SIEPLSGPMEGGTRITITGSNLGQKLEDIVDTVTVAGIQCQVDLLRYEISSRIVCVIASSLTE-- 1221

  Fly   954 RNGKIVVQI-GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAG--SRIQASIND 1015
            |.|.:.|:: |...|.|.:.:.:.:|.:..|:|..||.||||.:.:||..|..|  |.|...|.|
Frog  1222 RLGHVAVEVPGGGHGISSQVFSYQNPVLHSFSPTRGPKSGGTRLTLTGTKLLTGRPSDITVLIGD 1286

  Fly  1016 HLPCKILSTDSSQAI-CRTSASPGIIEGRLKMSFDNGPREFNDYN--FKYVLDPTVEHVSSGPSG 1077
             :||.|.|......: |.|.:|....:  |:::...|.:....|.  |.|..||.:  .|:.|:
Frog  1287 -IPCHIYSEMQENMLECLTGSSNSTAD--LQVTIKYGDQVLRTYESPFTYTADPNI--TSASPA- 1345

  Fly  1078 QIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNG----------------------------- 1113
                 |...:||..|.|:|.....:|.|.|.|..:.
Frog  1346 -----KSFISGGRMIFVSGQNLDVVQAPKIRVTVSPRERRRKRSLSRHRRIVPETECPENALCTV 1405

  Fly  1114 EMYASPCRVQSDTEMECASPV---------VDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVH 1169
            |.:...|.:.|...:.|.:|.         |||:               |::||:  ..|...::
Frog  1406 EKFEELCLINSSFLLLCKTPAINRLHWNSRVDVE---------------FILDNL--HFNFGAIN 1453

  Fly  1170 NNHFELYPNP--EYFIFEERVKYFK---SEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQ 1229
            :..|...|:|  :....|:.||.::   ...:::.|.|||.|..:.::...||:|.|.:.:|:|.
Frog  1454 SVPFTYEPDPVLKQLNPEDPVKPYRHKPGSVISVEGENLDLAITKDEMVAMIGDGVCMVKTLTRN 1518

  Fly  1230 QLTCRPPSEATATKSMNG-------PEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIAT 1287
            .|.|.||.:..|.:....       ||..|:|| .:...:|.:.|::.:.:....|..|...:.|
Frog  1519 HLYCEPPEKQPAPRQPQKREGVDSLPEFTVQIG-RMYLVLGKVQYDTESQLTFPLEAQIGLGVGT 1582

  Fly  1288 IVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSG 1352
            ..:.|::.:.:|: |::||.::.|..:.:|.|::.||..|...||:.|.:|.|||.|||.||...
Frog  1583 SFVALIVLIIVLI-YRRKSKQALRDYKKVQIQLENLETSVRDRCKKEFTDLMTEMMDLTSDLVGT 1646

  Fly  1353 GIPFLDYRSYAMKILFPNH-EDHIVLQWERPELLRK--EKGLRIFGQLIMNKTFLLLFIRTLESN 1414
            |||||||:|||.:|.||.| |..:....:.||..|:  |:||.....|:.:|.||..||.||||.
Frog  1647 GIPFLDYKSYAERIFFPGHRESPLQRDLDVPEGRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQ 1711

  Fly  1415 RYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSA 1479
            |.||.|:|..||||:.|:|..||||.||||||||.||:|:.:  ..:|||:|||||:|.||:|:.
Frog  1712 RTFSARDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYV--AKNPKLMLRRTETVVEKLLTN 1774

  Fly  1480 WFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYAS 1544
            |.:..||.|:::.||||||||||.:|.||||||||..|.:|:|:|::.:|:|..::::.:.:.|
Frog  1775 WMSICLYTFVRDSAGEPLYMLFRGIKHQVDKGPVDCVTGKAKYTLNDNRLLRDDVEYKTLTLNA- 1838

  Fly  1545 IIQ--QPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRT 1607
            |:|  ..|.|.      ...:.:.||:||||||.|||||.|:.||:..|...||..:.||||||:
Frog  1839 IMQTNTGITCE------EEAQGLPVKLLDCDTITQVKEKILDQIYKGTPYCNRPNPEALDLEWRS 1897

  Fly  1608 GATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYET 1672
            |..|.:||.|||:||.....||::||||||.|||||.::|||:.|        ...:.::|.|
Frog  1898 GLAGHLILSDEDLTSVVHGSWKRVNTLQHYKVPDGATVALVPRLS--------KHIHPENHDY-- 1952

  Fly  1673 LNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVK--------HHDSDMQKEGERVNKLVSEIY 1729
                        .....:|:..|..|.|:|.|||||        .|.....::.||. |.:.|||
Frog  1953 ------------IPGEKTPMLEDSDEGGVRVWHLVKPTDEPELPKHRRGSLRDRERA-KAIPEIY 2004

  Fly  1730 LTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNS 1794
            |||||:.||||||||||||:.|.||:.   .:|||:||.||.||:||..|||.|||.:|.||:||
Frog  2005 LTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFDLLDEQAISHGINDPETIHIWKTNS 2066

  Fly  1795 LPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEY 1859
            ||||||:|:||||.||.|:..|:.||:.|||:||||||||:.:||:||:|||.:|||||:|||.|
Frog  2067 LPLRFWINIIKNPQFVCDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARDIPRY 2131

  Fly  1860 RKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDE 1924
            ::.|:|||.|||.....|||:||:.|||.||..:.|.|:..||||||.|..||.:|:...||||.
Frog  2132 KQMVERYYSDIRQTISASDQEMNSALAELSRNCSGELNSLVALHELYKYINKYYDQIIEALEEDP 2196

  Fly  1925 FSQKQRLAFKLEQV 1938
            .:||.:|.::|:|:
Frog  2197 TAQKMQLGYRLQQI 2210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	145/468 (31%)
		PSI	522..574	CDD:279745	19/52 (37%)
		PSI	671..>699	CDD:279745	12/33 (36%)
		PSI	830..883	CDD:279745	14/53 (26%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	978..1063	CDD:238584	28/89 (31%)
		IPT	1078..1177	CDD:301692	23/136 (17%)
		IPT_PCSR	1196..>1255	CDD:238337	19/65 (29%)
		Plexin_cytopl	1353..1916	CDD:285529	287/575 (50%)
plxnb1	XP_012817153.2	Sema_plexin_B1	30..489	CDD:200536	146/476 (31%)
		PSI	491..542	CDD:396154	19/50 (38%)
		TIG_plexin	550..636	CDD:407808	28/90 (31%)
		PSI	650..>677	CDD:214655	12/26 (46%)
		TIG_2	1011..1107	CDD:407859	17/95 (18%)
		PSI	1108..1153	CDD:214655	14/53 (26%)
		IPT_plexin_repeat1	1155..1246	CDD:238585	35/92 (38%)
		IPT	1247..1334	CDD:417750	28/89 (31%)
		IPT	1337..1461	CDD:417750	26/148 (18%)
		Plexin_cytopl	1647..2188	CDD:400574	287/575 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22625
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110