Protein Alignment PlexA and plxnb1

DIOPT Version :10

• Sequence 1: NP_524637.2
• Gene: PlexA / 43832
• FlyBaseID: FBgn0025741
• Length: 1945
• Species: Drosophila melanogaster
• Sequence 2: XP_012817153.2
• Gene: plxnb1 / 100498269
• XenbaseID: XB-GENE-856606
• Length: 2221
• Species: Xenopus tropicalis
• Alignment Length: 2289
• Identity: 710/2289 - (31%)
• Similarity: 1042/2289 - (45%)
• Gaps: 510/2289 - (22%)

  Fly    61 LNSTITNVAAF--DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC---S 120
            ::.||..||..  :|..|||.:|..||.::||..|.||||:.:|.:...|:|||..||.||   .
 Frog    21 VSGTIPYVAFVQNNTIFNHLTLDANTGTLYVGATNSLYQLTENLAVEMLVRTGPVWDSKECLPPV 85

  Fly   121 ILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII----EHEV-PDAVV 180
            ..|||   ....|:|:||:||:..:...||.|||::||.|..|.|.:|..:    |..| ...|.
 Frog    86 STDCP---QAQNTNNHNKLLLVVPSKRELIVCGSVYQGICESRRLGSVQTVLFRPERPVDTQYVA 147

  Fly   181 ANDANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAV--- 242
            |||.|.:||..:|......|   :::||..||:..  ...||.:.:|:||.....::.|.:|
 Frog   148 ANDPNVTTVGLVALSKDGSP---LLFVGRGYTSKG--AGGIPPITTRNLEVGGDSEMESHSVFSY 207

  Fly   243 -TTGTRTFINSYARETYFVNYVYGFSSERFSYFL--TTQLKHSHHSSPKEYITKLVRICQEDSNY 304
             .|.....:...:.  |..:::..|:.:...|||  ...||    |..:||.|.:.|||..||:|
 Frog   208 EDTAKLAVVGRLSE--YNHHFIKAFTHKSNVYFLFYRRDLK----SQSREYKTYISRICPNDSHY 266

  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPT--NN 367
            |||.|:|:.|.:..:   .:||:||.::.:|...||:.: :....|||||.||:.:..:..  ..
 Frog   267 YSYVELPLSCRTKDK---SYNLLQAAYVTQPGERLAKGV-LKTDGDVLFAAFSQWQAASGKVGEE 327

  Fly   368 SALCIYSLKSIRRKFMQNIKSCFNGSGM----RGLDFISPSMP--CVLTKLQTIGEDFCGLD-VN 425
            |.||:||:..|.|...|...:|:...|.    |.:.:|...:.  ||.....|:....||.| ..
 Frog   328 SGLCLYSMDLIDRLINQTRDTCYTKDGKAEDGREVAYIEYDVKSNCVQLPSDTLDAYPCGSDHTP 392

  Fly   426 SPLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVD 489
            ||:..:.|:.:.|: ....|:.|::|......:|:.|:|.|.|:|.||.:.......:|:|....
 Frog   393 SPMASKDPLEATPLFESATTRFTAIAVHVEGEHTIAFIGDSKGYLNKVYLGGEQDTRQYSSVGTQ 457

  Fly   490 LGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSN 554
            ..|.:..|:.||.:..::|:::::.|.||.:.:||.:..|..||.|.|||||||.|..|||....
 Frog   458 SNSAVLPDLLFDQEEKHLYILTQSTVMKVPLSECSTFTDCDSCLSAGDPYCGWCVLYGKCSRSYE 522

  Fly   555 C-QDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTARTLELIIDHLPQL--KENLICAFTTEDKA 616
            | :....:...|...:..:|..:.|:.|..:.:...|.:.|.|..||.|  :|:..|.|  ||
 Frog   523 CLRSGQKNQWLWAYDQNQQCLAVQSLSPANISKEEKRNIFLSIPDLPALEHEESYSCFF--ED-- 583

  Fly   617 LFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCST------H 675
            ..:.|..:..||.|.:|.....|.|:.|..|...||.:|. ....:.||:|||:||..      :
 Frog   584 FESRAVIRDTGVMCPSPDPSKTPAIKPGTDHVQVKLVLRF-GEVTICSTEFTFYDCMAVAQLYKN 647

  Fly   676 SSCTRCVSSEFPCDWCVEAHRCTHDTA---------------------------ENCRNDILVTG 713
            :.|..||||::.|:||::.|.|||...                           |.....:|.|.
 Frog   648 APCRGCVSSDWGCNWCIQQHHCTHKATCEEGTIIYNKLTQIPFLDPTIPPEVPFELTTTVVLSTV 712

  Fly   714 VSRIGPSY--------------------------------------------------------- 721
            ||...||.
 Frog   713 VSETSPSEAPVTTASPTPSTTTFTTIPETSPTTFPPTTIPTTLPVTTPATTPTTVLQPDPSTAIL 777

  Fly   722 --------------------RSGPGFCPT------------------------------------ 730
                                .|.|...||
 Frog   778 DLATEDTIPDITMEPSTEEPTSRPTTIPTTMFVDIATSPPVTDNEYEEFTEESVLPELVTTEGST 842

  Fly   731 ------------------------------------INATG------------------------ 735
                                                :.:||
 Frog   843 TFYMTTTPVPVPPPTTPETQEEHPWVPTILHPTQEELTSTGQPITTPNQASSVSSLPGSPDEFHS 907

  Fly   736 --------------DGSE---------------------------VLVAG-----GTSKS----- 749
                          ||:|                           .:::|     |.|.|
 Frog   908 EIPFSEEPPTVPSEDGTEENLDQTEADDWADSASMDNDTSSFSASTILSGDGESDGVSPSFPGIL 972

  Fly   750 -------------------------------------------IKVKVHIIGQFI-----VQTRF 766
                                                       ::.|:.::|:..     .|..:
 Frog   973 EPDLDYQFDSPGLFEMDEEELIWGPEACPCVESIQSASLLPVNVERKITLVGKNFHHYQDQQMDY 1037

  Fly   767 VCQFNIEGRVTSLNAQLLGDT-------IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNI 824
            .|...:|||....:|.|..|.       |.|...::.|::......|...|.......:|:..::
 Frog  1038 DCVLLLEGRTVVTDAVLELDPEEESKYYITCQLHQYSYSALQLEFNAMVFVRIQSYLRVDSAEDL 1102

  Fly   825 HVVIYRCREMADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIH 888
            :|.:|.|......|..|.....||||.||..:: .|..:|.|.:..||         .||.|.||
 Frog  1103 YVTLYNCSVGHPDCSRCQTADPKYNCVWCGGSHPNCMYQETCKEKVEG---------TCPAPLIH 1158

  Fly   889 TFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY 953
            :.:|.:||.||||.|||.|.|||:...||...|.:|||.|......|..:.:|||.:.|...:
 Frog  1159 SIEPLSGPMEGGTRITITGSNLGQKLEDIVDTVTVAGIQCQVDLLRYEISSRIVCVIASSLTE-- 1221

  Fly   954 RNGKIVVQI-GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAG--SRIQASIND 1015
            |.|.:.|:: |...|.|.:.:.:.:|.:..|:|..||.||||.:.:||..|..|  |.|...|.|
 Frog  1222 RLGHVAVEVPGGGHGISSQVFSYQNPVLHSFSPTRGPKSGGTRLTLTGTKLLTGRPSDITVLIGD 1286

  Fly  1016 HLPCKILSTDSSQAI-CRTSASPGIIEGRLKMSFDNGPREFNDYN--FKYVLDPTVEHVSSGPSG 1077
             :||.|.|......: |.|.:|....:  |:::...|.:....|.  |.|..||.:  .|:.|:
 Frog  1287 -IPCHIYSEMQENMLECLTGSSNSTAD--LQVTIKYGDQVLRTYESPFTYTADPNI--TSASPA- 1345

  Fly  1078 QIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNG----------------------------- 1113
                 |...:||..|.|:|.....:|.|.|.|..:.
 Frog  1346 -----KSFISGGRMIFVSGQNLDVVQAPKIRVTVSPRERRRKRSLSRHRRIVPETECPENALCTV 1405

  Fly  1114 EMYASPCRVQSDTEMECASPV---------VDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVH 1169
            |.:...|.:.|...:.|.:|.         |||:               |::||:  ..|...::
 Frog  1406 EKFEELCLINSSFLLLCKTPAINRLHWNSRVDVE---------------FILDNL--HFNFGAIN 1453

  Fly  1170 NNHFELYPNP--EYFIFEERVKYFK---SEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQ 1229
            :..|...|:|  :....|:.||.::   ...:::.|.|||.|..:.::...||:|.|.:.:|:|.
 Frog  1454 SVPFTYEPDPVLKQLNPEDPVKPYRHKPGSVISVEGENLDLAITKDEMVAMIGDGVCMVKTLTRN 1518

  Fly  1230 QLTCRPPSEATATKSMNG-------PEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIAT 1287
            .|.|.||.:..|.:....       ||..|:|| .:...:|.:.|::.:.:....|..|...:.|
 Frog  1519 HLYCEPPEKQPAPRQPQKREGVDSLPEFTVQIG-RMYLVLGKVQYDTESQLTFPLEAQIGLGVGT 1582

  Fly  1288 IVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSG 1352
            ..:.|::.:.:|: |::||.::.|..:.:|.|::.||..|...||:.|.:|.|||.|||.||...
 Frog  1583 SFVALIVLIIVLI-YRRKSKQALRDYKKVQIQLENLETSVRDRCKKEFTDLMTEMMDLTSDLVGT 1646

  Fly  1353 GIPFLDYRSYAMKILFPNH-EDHIVLQWERPELLRK--EKGLRIFGQLIMNKTFLLLFIRTLESN 1414
            |||||||:|||.:|.||.| |..:....:.||..|:  |:||.....|:.:|.||..||.||||.
 Frog  1647 GIPFLDYKSYAERIFFPGHRESPLQRDLDVPEGRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQ 1711

  Fly  1415 RYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSA 1479
            |.||.|:|..||||:.|:|..||||.||||||||.||:|:.:  ..:|||:|||||:|.||:|:.
 Frog  1712 RTFSARDRAYVASLLTVSLHGKLEYFTDILKTLLNDLVEQYV--AKNPKLMLRRTETVVEKLLTN 1774

  Fly  1480 WFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYAS 1544
            |.:..||.|:::.||||||||||.:|.||||||||..|.:|:|:|::.:|:|..::::.:.:.|
 Frog  1775 WMSICLYTFVRDSAGEPLYMLFRGIKHQVDKGPVDCVTGKAKYTLNDNRLLRDDVEYKTLTLNA- 1838

  Fly  1545 IIQ--QPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRT 1607
            |:|  ..|.|.      ...:.:.||:||||||.|||||.|:.||:..|...||..:.||||||:
 Frog  1839 IMQTNTGITCE------EEAQGLPVKLLDCDTITQVKEKILDQIYKGTPYCNRPNPEALDLEWRS 1897

  Fly  1608 GATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYET 1672
            |..|.:||.|||:||.....||::||||||.|||||.::|||:.|        ...:.::|.|
 Frog  1898 GLAGHLILSDEDLTSVVHGSWKRVNTLQHYKVPDGATVALVPRLS--------KHIHPENHDY-- 1952

  Fly  1673 LNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVK--------HHDSDMQKEGERVNKLVSEIY 1729
                        .....:|:..|..|.|:|.|||||        .|.....::.||. |.:.|||
 Frog  1953 ------------IPGEKTPMLEDSDEGGVRVWHLVKPTDEPELPKHRRGSLRDRERA-KAIPEIY 2004

  Fly  1730 LTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNS 1794
            |||||:.||||||||||||:.|.||:.   .:|||:||.||.||:||..|||.|||.:|.||:||
 Frog  2005 LTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFDLLDEQAISHGINDPETIHIWKTNS 2066

  Fly  1795 LPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEY 1859
            ||||||:|:||||.||.|:..|:.||:.|||:||||||||:.:||:||:|||.:|||||:|||.|
 Frog  2067 LPLRFWINIIKNPQFVCDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARDIPRY 2131

  Fly  1860 RKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDE 1924
            ::.|:|||.|||.....|||:||:.|||.||..:.|.|:..||||||.|..||.:|:...||||.
 Frog  2132 KQMVERYYSDIRQTISASDQEMNSALAELSRNCSGELNSLVALHELYKYINKYYDQIIEALEEDP 2196

  Fly  1925 FSQKQRLAFKLEQV 1938
            .:||.:|.::|:|:
 Frog  2197 TAQKMQLGYRLQQI 2210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	145/468 (31%)
		PSI	522..574	CDD:396154	19/52 (37%)
		TIG_plexin	580..670	CDD:465588	28/91 (31%)
		PSI	671..>702	CDD:396154	14/36 (39%)
		TIG_2	738..829	CDD:465619	22/182 (12%)
		PSI	830..883	CDD:396154	14/53 (26%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	978..1063	CDD:238584	28/89 (31%)
		IPT	1078..1177	CDD:472823	23/136 (17%)
		TIG	<1196..>1246	CDD:460355	16/49 (33%)
		Plexin_cytopl	1353..1911	CDD:462434	285/570 (50%)
plxnb1	XP_012817153.2	Sema_plexin_B1	30..489	CDD:200536	146/476 (31%)
		PSI	491..542	CDD:396154	19/50 (38%)
		TIG_plexin	550..636	CDD:465588	28/90 (31%)
		PSI	650..>677	CDD:214655	12/26 (46%)
		TIG_2	1011..1107	CDD:465619	17/95 (18%)
		PSI	1108..1153	CDD:214655	14/53 (26%)
		IPT_plexin_repeat1	1155..1246	CDD:238585	35/92 (38%)
		IPT	1247..1334	CDD:472823	28/89 (31%)
		IPT	1337..1461	CDD:472823	26/148 (18%)
		Plexin_cytopl	1647..2183	CDD:462434	285/570 (50%)