DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxnc1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_031754770.1	Gene:	plxnc1 / 100492725	XenbaseID:	XB-GENE-856588	Length:	1523	Species:	Xenopus tropicalis

Alignment Length:	2006	Identity:	508/2006 - (25%)
Similarity:	784/2006 - (39%)	Gaps:	653/2006 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TITNVAAFDTKLNHLLVDTI------TGRVFVGGVNRLYQLSPDLELSETV-KTGPQNDSVECSI 121
            :|.:|.:.|.:   |||..:      :..|.|...:.||..  |..||:.: :|.....|.||.
Frog    18 SIDSVLSEDPR---LLVSAVRNIAVGSDYVVVATESCLYLF--DHTLSQRLAETSANESSTECR- 76

  Fly   122 LDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDAVVANDANS 186
            ...|..|.......||.:||:.|  ..:::|.......|..|.|.....|....||.:..|
Frog    77 GSAPGQATMGQKPPYNMLLLVYR--DIVLSCWITNTSFCNERKLNKFENISSITPDLLTPN---- 135

  Fly   187 STVAFIAPGPPQHPVTNVMYVGVTYTNNSPY---------RSEIPAVASRSLEKTKMFQIASSAV 242
                           |::...|:.::|...|         .|::..|:.::.|
Frog   136 ---------------TSLSAAGIVFSNEQTYLILATFTNKHSDLHPVSIKTRE------------ 173

  Fly   243 TTGTRTFI----NSYA--RETYFVNYVYGFSSER---FSYFLTTQLKHSHHSSPKEYITKLVRIC 298
               |..||    ||||  ..|..:.:|..||.||   |.||:           |:....|::.:.
Frog   174 ---TMGFITENENSYAELNTTTVLQFVNAFSWERIFFFPYFV-----------PELDNAKILSVK 224

  Fly   299 Q---EDSNYYSYTEIPVECISDAQGG---TKFNLVQAG---FLGKPSSDLAQSLGISIQDDVLFA 354
            .   .|...:....:|  |.||.:.|   :.|:.:::|   :.|                  :|.
Frog   225 NPKGADLQLWGLAHLP--CGSDIRRGVILSSFHFMKSGGHFWAG------------------IFT 269

  Fly   355 VFSKGEGNTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDFISPSMPCVLTKLQTIGEDF 419
              |:.:..:| :.:|||||:|.::    |:..|.|                         |.|||
Frog   270 --SQSQAMSP-DKTALCIYNLTNM----MKQEKEC-------------------------IAEDF 302

  Fly   420 ---CGLDVNSPLGGETPITSVPVAMFNT-------KLTSVAATSTSGYTVVFVGTSDGFLKKVVI 474
               |....:|..      .|:|:...|.       .|::|.|.......|.|:||.:|.:.||.:
Frog   303 RDECSSKDHSAK------NSLPILPINLGPTLTHGNLSAVFAVEVQNKMVFFLGTGNGQVLKVTL 361

  Fly   475 ESSSIAN-EYASFAVDLGSEINRDMQFDNQN-LYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARD 537
            :|...|| ....|..|..:.::|.::.|..| .||||.::.|:.::||.:|..:||..:||.|:|
Frog   362 DSEWKANCPEILFQFDNDTAVSRTIKADPVNSTYIYVAAENKIKRIKVANCESFKTYKECLSAKD 426

  Fly   538 PYCGWCSLENKCSPRSNCQDDANDPLYW--VSYKTGKCTTITSVVP---HQLQRTTARTLELIID 597
            ||||||..:.:|:..:.| ..::.|..|  :|.:.|...... |||   .|| |.||::..
Frog   427 PYCGWCHSQTRCTLNAEC-IPSDVPGNWNGMSEEGGNYLDFL-VVPIKDKQL-RITAKSSN---- 484

  Fly   598 HLPQLKENLICAFTTE----DKALFTNATKKRNGVNC-----TTPRTDMLPQIEQGKHHFTAKLS 653
                 .:|.....|.:    :|.| .|...::|.:.|     ||..:|            ..:|.
Frog   485 -----AKNTTWQCTVQNVGTNKTL-CNGVAEKNSMKCSCLVSTTGLSD------------NDQLG 531

  Fly   654 VRTRNGPDLVSTDFTFFDC-STHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRI 717
            :...||...||..|.|..| ...:.|..|:.|  .|.||
Frog   532 IELTNGKRSVSDVFQFKKCRQLQNRCMECIQS--GCLWC-------------------------- 568

  Fly   718 GPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTSLNAQ 782
                        |.|||
Frog   569 ------------TTNAT------------------------------------------------ 573

  Fly   783 LLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEK 847
                   |.|                        || .|                   |....||
Frog   574 -------CTS------------------------PL-TP-------------------CKDYGEK 587

  Fly   848 YNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQ----PKTGPWEGGTNITIRGI 908
            .||                            :.:.|.|   |:|    |:....:...||:|:.|
Frog   588 ANC----------------------------TALPPKP---TYQVMALPENSMLDNKDNISIKSI 621

  Fly   909 N-------------LGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVV 960
            :             .|:|..::||.:.....:|   |...::..|||           .:...|:
Frog   622 SSDRISYLGKDILITGENLQNLYSVLLFGTSSC---PAQNVEISQIV-----------NDTHAVL 672

  Fly   961 QIGDYRGESK--------------EDYEFVD-PKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQ 1010
            .:...|.|.|              :...:|. |...:.:|......||..|.||||:::..:.:.
Frog   673 SLPKSRKEVKSICFNPKENGCSENKTINYVSLPSCFNISPNTAWHGGGRNITITGKNMDIVNSLI 737

  Fly  1011 ASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGP 1075
            .|...|....|:....:.:.|:..| |...          .|.::.:.|.. |:|.|.
Frog   738 VSNTLHQWRPIILCPGNISQCKFLA-PQFA----------APTQWLNINMS-VVDNTF------- 783

  Fly  1076 SGQIKVPKGIPAGGIRISVTGTQFTSIQNP--NIYVVYNGEMYASPCRVQSDTEMECASPVVDVD 1138
                     |..|.::.         ::||  ..:.|.|          ..|||:|......:.:
Frog   784 ---------IACGSLKY---------LENPCFTSFAVLN----------DIDTELELRIKKTNDN 820

  Fly  1139 SHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNL 1203
            ..:...|..|.:.|            |:|::                :.:.|           |:
Frog   821 LGIQRQEMQIHIYY------------LNKIY----------------DCIVY-----------NI 846

  Fly  1204 DRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIG---TSLEY----R 1261
            .:..|||.|       ||.....||.::            .::..:|.|.:|   |.||.    |
Frog   847 TQNLKESTV-------FCKAKKDSRDKI------------DVSIMKVNVTLGNFTTILETPGFPR 892

  Fly  1262 IGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELR 1326
            :.||                  ::..::.|||:.:|..:..|:||.|.|   ..:.||::.||..
Frog   893 LYIL------------------LVLLLIPLLLVIIAACLVTKRKSKEMS---NKLSEQLEQLECD 936

  Fly  1327 VAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHE----DHIVLQWE------R 1381
            |..|.:..|||||.:..|:|.: :.|.||||||:.:|::...|..|    |.....:|      |
Frog   937 VIEEIRSGFAELQMDKLDMTVE-SLGTIPFLDYKHFALRTFLPEMEESKNDFTEKMYENVPSPFR 1000

  Fly  1382 PELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKT 1446
            ...:.:.:.|.:..:|...|.||:..|.|||....||:|:|...||.:.::.||.|.|.|::|:.
Frog  1001 NRTVDENEHLHLLRKLFEKKRFLVHLIHTLEHQSNFSVRDRCRFASFLTISFQSNLVYLTELLEV 1065

  Fly  1447 LLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKG 1511
            |:.||:::  .....|||:|||||||.||:|:.|.:..||.:|:|..|||||:|...:..::.||
Frog  1066 LIKDLMDQ--SSNKQPKLMLRRTESVVEKLLTNWMSTCLYGYLREFVGEPLYLLVCMLNQRIHKG 1128

  Fly  1512 PVDACTHEARYSLSEEKLIRQ------SIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVL 1570
            |:||.|.:|.|:|:|:.|:.|      |:|   :|||        |.|..:  .:.||::.|.||
Frog  1129 PIDAITCKALYTLNEDSLLWQINAKFSSLD---LNVY--------FPNGSE--ENVTESIKVTVL 1180

  Fly  1571 DCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVI--------LYDEDVTSKT-ES 1626
            ||||:||.|||.::..:         .|...:..:....||.|:        |.|.|.||.. |:
Frog  1181 DCDTVGQAKEKIVQKFF---------IKKGYNWGFPLHDTGLVLHHGQLQKQLSDIDNTSVVLEN 1236

  Fly  1627 EWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSP 1691
            ...|||||:||.:.||..:.::                          |.|
Frog  1237 GIIKLNTLKHYKIEDGVTVKVI--------------------------IQK-------------- 1261

  Fly  1692 LNNDMH--ENGLRYWHLV-KHHDSDMQKEGERVNK-----LVSEIYLTRLLATKGTLQKFVDDLF 1748
             |.|:.  ||..:|:||| .......|.|||. |:     .|.|:|||:||:||..:...|:.||
Frog  1262 -NCDVQDLENSSKYYHLVLPSSQGSEQIEGEE-NQGKHKFQVKELYLTKLLSTKVAIHSSVEKLF 1324

  Fly  1749 ETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDI 1813
            .:|::..  .:..|.|:||.||.||.||::..|||.:|:|.||:||||||||||::|||.||||:
Frog  1325 RSIWTIP--TNKPPTAVKYFFDLLDSQAEIKKITDLDVLHIWKTNSLPLRFWVNILKNPQFVFDL 1387

  Fly  1814 HKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISD 1878
            .|:::::|||||:||.||||.|.|:..|||.||::|||||||||.:::.|..||:.|||..|:|.
Frog  1388 KKTHLLESCLSVIAQAFMDSFSISEQHLGKSSPTNKLLYAKDIPMFKEEVKNYYKGIRDAPPVSS 1452

  Fly  1879 QDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEED---EFSQKQRL 1931
            .::|..|..||:.|..||..:.||.|||.|..:|::.:...||::   |..|||.|
Frog  1453 AELNEFLMAESKKHENEFKEDVALLELYKYIKRYHQVVLDMLEKEPGFEDEQKQLL 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	107/490 (22%)
		PSI	522..574	CDD:279745	19/53 (36%)
		PSI	671..>699	CDD:279745	7/28 (25%)
		PSI	830..883	CDD:279745	5/52 (10%)
		IPT_plexin_repeat1	885..977	CDD:238585	21/122 (17%)
		IPT_plexin_repeat2	978..1063	CDD:238584	17/84 (20%)
		IPT	1078..1177	CDD:301692	15/100 (15%)
		IPT_PCSR	1196..>1255	CDD:238337	11/58 (19%)
		Plexin_cytopl	1353..1916	CDD:285529	224/595 (38%)
plxnc1	XP_031754770.1	Sema	32..410	CDD:417757	105/485 (22%)
		PSI	411..458	CDD:396154	17/47 (36%)
		IPT	704..>739	CDD:214657	9/34 (26%)
		Plexin_cytopl	962..1488	CDD:400574	224/593 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D90434at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010