DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and met

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001007125.1	Gene:	met / 100150664	ZFINID:	ZDB-GENE-041014-1	Length:	1382	Species:	Danio rerio

Alignment Length:	1809	Identity:	361/1809 - (19%)
Similarity:	588/1809 - (32%)	Gaps:	719/1809 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PIKNAKNLNSTITNVAAF---DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQND 115
            ||:::| |:.::|....:   ||.:..||  .|.|.|:||.|||||.||.||:.....||||.::
Zfish    29 PIESSK-LDLSVTYDLPYFVSDTPIQKLL--EINGTVYVGAVNRLYALSKDLKKKHEYKTGPVHE 90

  Fly   116 SVECSILDCPLNAVRSPTD-------------NYNKVLLIDRATS-RLIACGSLFQGTCTVRNLQ 166
            ..:|          ::|||             |.|..||::.... .|.:|||:..|.|:
Zfish    91 GPDC----------KTPTDQCSGCENKPRNINNTNMALLMETFYDLELFSCGSVGNGVCS----- 140

  Fly   167 NVSIIEHEVPDAVVA----------NDANSSTVAFIAPGPPQHPVTNVM---YVGVTYTNNSPYR 218
                 .|.:.|..:.          |:.:|........||....:.|:|   .|.....|:.|..
Zfish   141 -----RHVLEDGPLGAEVTCMYTKKNEGSSHGCPDCLAGPAGTQILNIMSGRVVRFFVANSEPLE 200

  Fly   219 SEIP----AVASRSLEKTK-MFQIASSAVTTGTRTFINSY------ARETYFVNYVYGFSSERFS 272
            |..|    .::.|.:.:|: .|:..|.          .||      .|..|.::|||.|.|..:.
Zfish   201 SNGPRLHHTISIRKMRETQDGFEFFSE----------QSYMDLAPSLRGNYPLHYVYSFQSGPYV 255

  Fly   273 YFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTK------FNLVQAGF 331
            ||||.|   ....:.|.:.|::||:|..||....|.|:|.|||...:...|      ||::||..
Zfish   256 YFLTVQ---REGGNSKAFHTRIVRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAH 317

  Fly   332 LGKPSSDLAQSLGISIQDDVLFAVF--SKGEGNTPTNNSALCIYSLKSIRRKFMQNIKS------ 388
            :.|...|..|.:|:...:|||||.|  ||.:...||.:||:|:.|:..|...|...|:.
Zfish   318 VAKVGYDFQQEMGLKEGEDVLFAAFARSKPDSPEPTASSAVCLISITDINEFFKVFIQKGYTRKL 382

  Fly   389 -CFNGSGMRGLDFISPSMPCVLTKLQT-IGEDF-CG-------LDVNSPLGGETPITSVPVAMF- 442
             .|.||..:             |..|| :|:.| ||       |:|.|    ..|........|
Zfish   383 HHFPGSEEK-------------TFNQTFVGDSFSCGKHERGYRLEVTS----TNPRRDYFHGRFR 430

  Fly   443 NTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYI 507
            |..|||:|......:|||.:||::|.:.:||:..
Zfish   431 NVLLTSIAVVPIQNHTVVSLGTAEGRVIQVVVSR------------------------------- 464

  Fly   508 YVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGK 572
              ..||:
Zfish   465 --FGKTE---------------------------------------------------------- 469

  Fly   573 CTTITSVVPHQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTDM 637
                    ||             :|.                                   |.||
Zfish   470 --------PH-------------VDF-----------------------------------RLDM 478

  Fly   638 LPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTA 702
            ||                                          ||||
Zfish   479 LP------------------------------------------VSSE----------------- 484

  Fly   703 ENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKV-KVHIIGQFIVQTRF 766
                       ::.:.|.:.             :||.:|:.|.     || |:.:||....|
Zfish   485 -----------MALLSPQHH-------------NGSLLLITGD-----KVSKLPVIGPGCEQ--- 517

  Fly   767 VCQFNIEGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRC 831
                                                        :|
Zfish   518 --------------------------------------------LW------------------- 519

  Fly   832 REMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGP 896
                 :|..||.......||||.::|.|....:|.:::     |:..|  || ..|.:..|.:.|
Zfish   520 -----TCSSCLLAPGFMGCGWCRTSNRCTRAPRCPQSQ-----WIQDS--CP-LLITSISPSSAP 571

  Fly   897 WEGGTNITIRGINLGKNYNDIYS----GVRIAGINCMPFPQFYIDTK-----QIVCTVDSPGEQM 952
            ..|.|||||.|.|.|.|..|.:.    .|.:||..|.      ::.|     ::||.:|
Zfish   572 LRGQTNITICGKNFGFNKKDRFDTKLVDVVVAGTKCK------LERKDSNNNRLVCGLD------ 624

  Fly   953 YRN-----GKIVVQIGDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQAS 1012
            |.|     ..|.|:.|..:.: |:.:.||:|.|::..|:|||.||||.:.|:|..|::|: :|..
Zfish   625 YVNWSSLDSVITVRSGKEQAQ-KDGFSFVNPVIIEIFPEFGPQSGGTMLTISGSFLDSGN-VQTV 687

  Fly  1013 INDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFD----NGPREFNDYNFKYVLDPTVEHVSS 1073
            ...:..|.:.|..::...|||...|...:.::::..|    ..|     .::.|..:|   |:||
Zfish   688 TVGNATCVLQSVSATMLTCRTPPQPSPSQHKVQLHIDGVIFEAP-----VSYTYNKNP---HISS 744

  Fly  1074 GPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYV--VYNGEMYASPCRVQSD-TEMECASPVV 1135
                 ::......:||..::|.|....|...|.:.:  ...|:::...|....| ..:.|.:|.:
Zfish   745 -----VQPKHSFISGGSTVTVNGFYLHSALQPQMVLTAATEGKLFQVTCSHDEDKRNILCITPSL 804

  Fly  1136 DVDSHVIEAERPILLEYGFLMDNVLRVQ-NLSKVHNNHFELYPNP------EYFIFEERVKYFKS 1193
                ..:..:.|:..:..|::|.....| :|..|.:..||.:..|      :..|.|.:|.....
Zfish   805 ----KGLSVQPPVATKMTFVLDGFSTDQYDLLYVEDPKFEEFQKPTVTPRGKKNILEIKVPPVNQ 865

  Fly  1194 EYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQLTCRPPSE-ATATKSMNGPEVIVRIGTS 1257
            |           |.|..:| :::.|..|...:|....|.|..|.| .||.|.:   ||..:..||
Zfish   866 E-----------AVKNGEV-LRVSNRTCESVTLVGNTLECTVPMELQTAAKEL---EVEWKQATS 915

  Fly  1258 --LEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSR--------- 1311
              :..|:.:...:...|::..|      |..:|::||||.|.:.:..||...:.::
Zfish   916 SVILGRVILAQDQDYRILITGG------VCVSILLLLLIAVFVWIKRKKHIDDLAKTMVWYDGRA 974

  Fly  1312 ------VLRNMQ-----------EQMDI---------LELRVAAECK-----EAFAELQTEMTDL 1345
                  :|.|.:           |.:|.         |.|.....|:     .:..:|...:..:
Zfish   975 HIPHLDMLANARSVSPTDEMVSHESVDYRTTLLEDQNLPLSQTESCRPHLYAHSHVDLSPMLGPM 1039

  Fly  1346 TGDLTSGGIPF---LDYRSYAMKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLF 1407
            .|||.|..:|.   :|..|.                  .||||:..:      .:::.:..|||.
Zfish  1040 EGDLASPLLPSTAPIDLGSL------------------HPELLKXVQ------HVVIAREDLLLH 1080

  Fly  1408 IRTLESNRYF------------SMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKS 1460
            :..:....:|            ..::...:.||..:|   .:|..:..||..:      .::..|
Zfish  1081 VNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRIT---DIEEVSQFLKEGI------IVKDFS 1136

  Fly  1461 HPKLLLRRTESVAEKMLSAWFTFLLYKFLKEC---AGEPLYMLFRAVKGQVDKGPVDACTHEARY 1522
            ||.:|                     ..|..|   .|.||.:|.....|.:.....|.
Zfish  1137 HPNVL---------------------SLLGICLPSEGSPLVVLPYMKHGDLRNFIRDE------- 1173

  Fly  1523 SLSEEKLIRQSIDF-----RPMNVYAS--IIQQPIFCNN--LDMLPSHTENVSVKVLDCDTIGQV 1578
              |....::..:.|     :.|...||  .:.:.:...|  ||      |:.:|||.|   :|..
Zfish  1174 --SHNPTVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLD------ESYTVKVAD---VGLA 1227

  Fly  1579 KEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTS-------KTESEWKKLNTLQH 1636
            ::                                  :||::..|       |...:|..|.:||.
Zfish  1228 RD----------------------------------VYDKEYYSVHNKHGVKLPVKWMALESLQT 1258

  Fly  1637 YNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGS 1690
            :.         ...:|.:::|.:|        .:|.:     |..:|.:|...|
Zfish  1259 HK---------FTTKSDVWSFGVL--------LWELM-----TRGAPPYSDVNS 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	134/507 (26%)
		PSI	522..574	CDD:279745	0/51 (0%)
		PSI	671..>699	CDD:279745	4/27 (15%)
		PSI	830..883	CDD:279745	12/52 (23%)
		IPT_plexin_repeat1	885..977	CDD:238585	29/105 (28%)
		IPT_plexin_repeat2	978..1063	CDD:238584	23/88 (26%)
		IPT	1078..1177	CDD:301692	19/102 (19%)
		IPT_PCSR	1196..>1255	CDD:238337	15/59 (25%)
		Plexin_cytopl	1353..1916	CDD:285529	59/372 (16%)
met	NP_001007125.1	Sema_MET_like	43..511	CDD:200509	156/754 (21%)
		PSI	514..559	CDD:214655	14/122 (11%)
		IPT	562..653	CDD:301692	29/103 (28%)
		IPT_plexin_repeat2	654..736	CDD:238584	23/87 (26%)
		IPT	740..823	CDD:301692	17/94 (18%)
		Pkinase_Tyr	1079..1338	CDD:285015	50/316 (16%)
		PTKc_Met_Ron	1083..1344	CDD:270649	49/312 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810