DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxna2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001116947.1	Gene:	plxna2 / 100144723	XenbaseID:	XB-GENE-856549	Length:	1898	Species:	Xenopus tropicalis

Alignment Length:	1962	Identity:	806/1962 - (41%)
Similarity:	1140/1962 - (58%)	Gaps:	183/1962 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----S 120
            :|::|. |....|...:||.|...||.|:||.|||:|:||.:|.|..:..|||..|:..|    :
Frog    39 SLSNTF-NTEHRDWTFSHLTVHQTTGAVYVGAVNRIYKLSGNLTLLVSHNTGPGEDNKSCYPPQN 102

  Fly   121 ILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII---EHEVPDAVVAN 182
            :..|  :..|:.|:|.||:|:||.|.:||:|||||:||.|.:..|.::.|:   .|:....:.:.
Frog   103 VQPC--SEPRTLTNNVNKLLIIDYAENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSV 165

  Fly   183 DANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSA 241
            :...:....|.....|   ...:::|........|   .|.::||.|    |.:.|  :::.|..
Frog   166 NETGTMYGVIVHTEGQ---DGKLFIGTAVDGKQDY---FPTLSSRKLPRDPESSTMLDYELYSDF 224

  Fly   242 VTTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLK-----HSHHSSPKEYITKLVRICQE 300
            |::..:...::.|..::| :.|||||||..:.||||.|.:     .|:.::...|.:::||:|:.
Frog   225 VSSLIKIPSDTLALVSHFDIFYVYGFSSGNYVYFLTVQPETPEGISSNSANDLFYTSRIVRLCKN 289

  Fly   301 DSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG--NT 363
            |..::||..:|:.|   .:.|.::.|:||.:|.||.:.||:||.|:.|||||||:||||:.  :.
Frog   290 DPKFHSYVSLPIGC---TKNGVEYRLLQAAYLTKPGATLARSLKITTQDDVLFAIFSKGQKQYHH 351

  Fly   364 PTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGLDVNS 426
            |.::|.||::.:|:|.....:.::||:.|.|...|:: :...:.|  ||... |.::|||||:|.
Frog   352 PPDDSTLCVFPIKTINSLIKERLQSCYQGEGHLELNWLLGKDVQC--TKAPVPIDDNFCGLDINQ 414

  Fly   427 PLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIE---SSSIANEYASFA 487
            ||||.|.:..|.: .....::||:|:...:.|:||||||..|.:||:..:   ...|..|..:..
Frog   415 PLGGSTMVEGVTLYTESRDRMTSLASYVYNNYSVVFVGTKSGRIKKIRADGPPDGGIPYEVVNVT 479

  Fly   488 VDLGSEIN--RDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCS 550
            .|   ||.  |||.|...|.|:||||:.:||:|:|..|..|.:|.:||.:.||:||||.|.|.||
Frog   480 RD---EIPLLRDMAFSTDNKYLYVMSERQVSRVEVEHCEQYSSCEECLSSGDPHCGWCVLHNTCS 541

  Fly   551 PRSNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTT-ARTLELIIDHLPQLKENLICAFTTED 614
            .:..| :.|::|..:.. ...:|..: .|.|:.|..:. :..|.|.:.::|.|...:.|||
Frog   542 RKDKC-ERAHEPFRFAD-NMKQCVKV-DVQPNSLPVSEHSLLLTLKVSNVPDLSAGVTCAF---- 599

  Fly   615 KALFTNATKKRNG-------VNCTTPRTDMLPQIEQGKHHFTAKLS-VRTRNGPDLVSTDFTFFD 671
                 ...|:..|       ::|.:|....:|.:...:..|..:|. :....|...|||:|.|::
Frog   600 -----GDLKQEEGQVQSGSRIDCVSPAAKDIPTMLAAQDWFGVELQLISKETGKTFVSTNFKFYN 659

  Fly   672 CSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGD 736
            ||.|..|..||:.:|.|.||...:.||||.. :|              |::.|     .:|.:.|
Frog   660 CSAHQHCLSCVNGDFRCHWCKYRNLCTHDPT-SC--------------SFQEG-----RVNVSED 704

  Fly   737 ------GSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSM 793
                  ..|:|:..|..:.|.:|...:.| ...|..:.|..||:|.|..:.| :....::.|.:.
Frog   705 CPQLVPSEEILIPVGEVRPITLKARNLPQPQSGQRGYECVLNIQGVVHRMPALRFNSSSVQCQNS 769

  Fly   794 EFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTN 857
            .:.|.... .:|...|:|:|.|:..:|||..|.|.:|:|..:.:|||:||....||.||||:...
Frog   770 SYIYEGMDVSDLPVDFSVVWNGNFTIDNPQLIKVHLYKCAALRESCGLCLKADHKYECGWCNGEG 834

  Fly   858 TCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVR 922
            .|.:...|...:....||.:|:..|.||.||.....:||.||||.:||||.|||.|:::|...|.
Frog   835 RCTLHHHCMSPQNQWLDWSSRNVKCINPRIHEILTVSGPPEGGTRVTIRGANLGLNFSEIAQNVV 899

  Fly   923 IAGINCMPFPQFYIDTKQIVCTVD--SPGEQMYRNGKIVVQIGDYRGE----SKEDYEFVDPKIL 981
            :||:.|.|..:.||..:||||.:.  ||...   :|.:::.|.:.:.|    |.:.|.||.|.:.
Frog   900 VAGVQCTPVEEEYIIAEQIVCEMGQASPTSS---SGPVLLCIEECKPEFMARSLQQYTFVSPTVA 961

  Fly   982 DFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASP-GIIEGRLK 1045
            ..:|..||.||||.|.|||.:|.|||.:..::.:. .|:......::.:|.|:.|. |:....:.
Frog   962 HLSPSRGPESGGTMITITGHNLAAGSIVSVTLGNQ-TCEYYGRSLNEIVCVTAPSTHGLGPVHVS 1025

  Fly  1046 MSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQNPNIYV 1109
            :|.|....|.| ..|:|:.||.|..:.         |: .|.:|...::|.||....||.|.|.|
Frog  1026 VSVDRAQLESN-LQFEYIDDPKVLRIE---------PEWSIASGHTSLTVIGTNLDIIQQPRIRV 1080

  Fly  1110 VYNGEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSKVHNNH 1172
            ..||:...:.|:|.:.|.:.|.:|.:.::..  :...|||  .|:||:.:|   ||:|...:|..
Frog  1081 KSNGKESVNVCKVVNATCLTCLAPALTLEYRPGLDSVERP--NEFGFIFNN---VQSLLVFNNTK 1140

  Fly  1173 FELYPNPEYFIFEER--VKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNITSLSRQ 1229
            |..||||.:.:....  ::......:.:.||||   |..:      ...|.||...|.:| :|..
Frog  1141 FIYYPNPTFELLSPNGVLEQKPGSPIILKGRNL---CPPATGGAKLSYTVLIGKTPCAVT-VSET 1201

  Fly  1230 QLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV---- 1289
            ||.|..|       ::.|. :|.|.:|..      :.|..|.|:|.|  ..:....|.:|.
Frog  1202 QLLCESP-------NLTGQHKVTVYVGGM------VFSPGSINVIPD--SLLTLPAIVSIAAGGS 1251

  Fly  1290 ILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGI 1354
            :||:|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...||
Frog  1252 LLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGI 1316

  Fly  1355 PFLDYRSYAMKILFPNHEDHIVLQWERPELLRK---EKGLRIFGQLIMNKTFLLLFIRTLESNRY 1416
            |.||||:|||::|||..|||.|||....:..|:   ||.|::|.|||.||.|||.||||||..|.
Frog  1317 PHLDYRTYAMRVLFPGIEDHPVLQELEVQGNRQQSVEKALKLFAQLINNKVFLLTFIRTLELQRS 1381

  Fly  1417 FSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWF 1481
            ||||:|.|||||||..||.||||.||:||.||.|||||.:|.|:|||||||||||||||||:.||
Frog  1382 FSMRDRGNVASLIMTALQGKLEYATDVLKQLLSDLIEKNLENKNHPKLLLRRTESVAEKMLTNWF 1446

  Fly  1482 TFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASII 1546
            .|||:|||||||||||:||..|:|.|::|||:|:.|.||||||||:|||||.|:      |.::|
Frog  1447 AFLLHKFLKECAGEPLFMLHCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIE------YKTLI 1505

  Fly  1547 QQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATG 1611
               :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:|||||.|...
Frog  1506 ---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIA 1565

  Fly  1612 RVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNIS 1676
            ||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|......:||
Frog  1566 RVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASASISRTSIS 1623

  Fly  1677 KYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLAT 1736
            :|.|:     ||...|:.:|:.....|:|::.|||||:|:...||||:|.:|:||||||||||||
Frog  1624 RYDSTFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLAT 1688

  Fly  1737 KGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWV 1801
            ||||||||||||||:|||.||||||||||||||||||:||..|||.|.:|.||||||.|||||||
Frog  1689 KGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHGIYDTDVRHTWKSNCLPLRFWV 1753

  Fly  1802 NLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRY 1866
            |:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.|:.||:||
Frog  1754 NVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKNWVERY 1818

  Fly  1867 YRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRL 1931
            |.||..:..||||||||.|||:||:|..|||...||:|:|:|..||:.:|...||:||..::.||
Frog  1819 YADIAKLPAISDQDMNAYLAEQSRMHAAEFNIMSALNEIYSYVSKYSVELITALEQDEQGRRHRL 1883

  Fly  1932 AFKLEQVHNIMS 1943
            |:|:||:...||
Frog  1884 AYKVEQLIGAMS 1895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	161/473 (34%)
		PSI	522..574	CDD:279745	18/51 (35%)
		PSI	671..>699	CDD:279745	11/27 (41%)
		PSI	830..883	CDD:279745	17/52 (33%)
		IPT_plexin_repeat1	885..977	CDD:238585	37/97 (38%)
		IPT_plexin_repeat2	978..1063	CDD:238584	26/85 (31%)
		IPT	1078..1177	CDD:301692	30/101 (30%)
		IPT_PCSR	1196..>1255	CDD:238337	18/65 (28%)
		Plexin_cytopl	1353..1916	CDD:285529	358/570 (63%)
plxna2	NP_001116947.1	Sema_plexin_A2	41..555	CDD:200533	183/531 (34%)
		TIG_plexin	569..658	CDD:375449	21/97 (22%)
		PSI	659..706	CDD:366642	19/66 (29%)
		TIG_2	712..806	CDD:375492	25/93 (27%)
		PSI	808..859	CDD:366642	17/50 (34%)
		IPT_plexin_repeat1	862..956	CDD:238585	36/96 (38%)
		IPT_plexin_repeat2	958..1041	CDD:238584	26/84 (31%)
		IPT_plexin_repeat3	1045..1145	CDD:238586	32/113 (28%)
		TIG	1147..1229	CDD:366832	21/98 (21%)
		Plexin_cytopl	1315..1867	CDD:369821	358/569 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	705	1.000	Domainoid score	I123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56427
Inparanoid	1	1.050	1383	1.000	Inparanoid score	I130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm49109
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070