DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxna1

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_031755564.1	Gene:	plxna1 / 100037845	XenbaseID:	XB-GENE-5819524	Length:	1931	Species:	Xenopus tropicalis

Alignment Length:	1977	Identity:	823/1977 - (41%)
Similarity:	1147/1977 - (58%)	Gaps:	194/1977 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC----SILDCPLNAVRSP 132
            |..|.||:|...||.|::|.:||:|:||.:|.|..|..|||..|:.:|    |:..||...|  .
Frog    41 DWSLTHLVVHNKTGEVYLGAINRIYKLSNNLTLMRTHVTGPVEDNEKCYPPPSVQSCPHGLV--S 103

  Fly   133 TDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII--EHEVPDAVVANDANSSTVAFIAPG 195
            |:|.||:||||.:.:|||||||..||.|....|.::..:  .|...:..:::...|.|::.:...
Frog   104 TNNVNKLLLIDYSENRLIACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVNESGTMSGVIIE 168

  Fly   196 PPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVTTGTRTFI 250
            .|..  .|.::||......|.|   .|.::||.|    |..:||      :..||.:...:.| :
Frog   169 VPNG--QNKLFVGTPIDGKSEY---FPTLSSRKLMGNEENAEMFGFVYQDEFVSSQLKIPSDT-L 227

  Fly   251 NSYARETYFVNYVYGFSSERFSYFLTTQLK---HSHHSSPKEYIT-KLVRICQEDSNYYSYTEIP 311
            :.:  .|:.:.|||.||||:|.|:||.||.   .|..|:.:::.| |:||:|.:|..:|||.|.|
Frog   228 SKF--PTFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDSTGEQFFTSKIVRLCVDDPKFYSYVEFP 290

  Fly   312 VECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNNSALCIYS 374
            :.||.|   |.::.|:|..:|.||...||:.||||.::|:||.|||:|:.|  .|...|.:|:::
Frog   291 IGCIKD---GVEYRLIQDAYLSKPGKRLAKELGISEREDILFTVFSQGQKNRIKPPKESVMCLFT 352

  Fly   375 LKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVP 438
            ||.|:.|..:.|:||:.|.|...|.: ::..:.|:.:.|| |.::|||.|.|.||||...|...|
Frog   353 LKKIKDKIKERIQSCYRGDGKLSLPWLLNKELGCINSPLQ-IDDNFCGQDFNQPLGGTVTIEGTP 416

  Fly   439 VAMFNTK---LTSVAATSTSGYTVVFVGTSDGFLKKVVIE---SSSIANEYASFAVDLGSEINRD 497
              :|..|   :|||||....|:||||.||..|.:||::::   ||.:|.:|.:..|..|:.|.||
Frog   417 --LFLDKEDGMTSVAAYDYRGHTVVFAGTRSGRMKKILVDLSASSHMAQQYENVVVHEGNAILRD 479

  Fly   498 MQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDP 562
            :.......|||.|::.:|::|.|..|..|:||..|||:|||:||||.|.|.||.:..|  :..|.
Frog   480 LVLSPDRQYIYAMTEKQVTRVPVESCEQYETCDACLGSRDPHCGWCVLHNMCSRKDKC--ERADE 542

  Fly   563 LYWVSYKTGKCTTITSVVPHQLQRTTARTLELIID--HLPQLKENLICAFTTEDKALFTNATKK- 624
            |:..:....:|..:| |.|..:. .|...:.:::.  ::|.|...:.|:|  ||   ||....:
Frog   543 LHRFTSDQRQCVQLT-VHPRNIS-VTVSEVPMVLQAWNVPDLSAGVNCSF--ED---FTEMEGRI 600

  Fly   625 -RNGVNCTTPRT-DMLPQIEQGKHHFTAKLSVRTR-NGPDLVSTDFTFFDCSTHSSCTRCVSSEF 686
             ...:.||:|.| |::|...........||.:::: .|....|.||.|::||.|.||..||:..|
Frog   601 LDGKIYCTSPSTKDVIPITRGHGDKRVLKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSF 665

  Fly   687 PCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIK 751
            ||.||...|.|||:.|: |              |::.|     .:|.:.|..::|    .|..|.
Frog   666 PCHWCKYRHVCTHNAAD-C--------------SFQEG-----RVNMSEDCPQIL----PSTQIY 706

  Fly   752 VKVHIIGQFIV-----------QTRFVCQFNIEGRVTSLNAQLLGDT-IYCDSMEFQYTSRS-PN 803
            :.|.::....:           |..:.|.|:|.|.||.:.|.....| |.|.:..:.|.... .:
Frog   707 IPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQCQNTSYNYEGNDISD 771

  Fly   804 LTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKN 868
            |....:|:|.|...:|||.||...:|:|..:.:|||:||...:::.||||.|...|.:.:.|
Frog   772 LPVNLSVVWNGHFVIDNPQNIQAHLYKCSALRESCGLCLKSDQRFECGWCVSEKKCTLRQNC--- 833

  Fly   869 KEGKTDWLNRSEI---CPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMP 930
            ...:..|::.|.:   |.:|:|....|:|||.:|||.:||.|.|||..:.||..|||:..:.|:|
Frog   834 PAYENPWMHASTVNSRCTDPKITKLFPETGPKQGGTLLTITGENLGLRFEDIRFGVRVGHVMCVP 898

  Fly   931 FPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQI----GDYRGESKEDYEFVDPKILDFNPKFGPTS 991
            ....||..:||||.:...|:......::.|.:    .|||..|.:.:.||.|......|..||.|
Frog   899 IENEYISAEQIVCEIKDAGKMRVHEAQVEVCVKDCSQDYRAISPKSFTFVVPSFNRVTPSRGPLS 963

  Fly   992 GGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFN 1056
            |||.|.|.|.:||:||.:...|... ||......:.:..|:|...|...:..:::..:......:
Frog   964 GGTWISIEGSYLNSGSDVSVDIGGR-PCMFSWRTAKEIRCKTPQGPSTGKAEIQIHINRATLYNS 1027

  Fly  1057 DYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCR 1121
            :.::.|..||||:        :|:....|.:||..:.|||....:|:.|.|...|......:.|.
Frog  1028 EVHYNYTEDPTVQ--------KIEPEWSIASGGTPLIVTGLNLATIKEPKIRAKYGDAERENNCT 1084

  Fly  1122 VQSDTEMECASPVVD--VDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIF 1184
            |.:||.|.|.:|.|:  :.|.....:||.  |.||:|||||.   |..|:...|..||:|   :|
Frog  1085 VYNDTTMVCLAPSVENPLRSPPENGDRPD--EIGFIMDNVLA---LLIVNTTSFLYYPDP---VF 1141

  Fly  1185 EE-----RVKYFKSEYLTINGRNLDRACKES---DVEVKIGNGFCNITSLSRQQLTCRPPSEATA 1241
            |.     .::...|..|.|.||||..|...:   :..|.||:..|.:| :|..||.|..|
Frog  1142 EPLTASGNLELKPSSPLIIKGRNLIPAAPGNFRLNYTVLIGDTPCALT-VSETQLLCESP----- 1200

  Fly  1242 TKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIV-------ILLLIFVAL 1298
              ::.|. :|.::.| ..||..|.|...|.:::          .:..|:       :||||.:.:
Frog  1201 --NLTGQHKVTIKAG-GFEYSPGTLQIYSDSLL----------TLPAIIGIGGGGGLLLLIIIIV 1252

  Fly  1299 LVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYA 1363
            |:|||:||.::.|.|:.:|.|||.||.|||.|||||||||||::.:||.||...||||||||:||
Frog  1253 LIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYA 1317

  Fly  1364 MKILFPNHEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASL 1428
            |::|||..|||.||: |.......||.|.:||||:..|.|||.||||||:.|.||||:|.|||||
Frog  1318 MRVLFPGIEDHPVLK-EMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASL 1381

  Fly  1429 IMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECA 1493
            ||..||.::||.|.:||.||.|||||.:|.|:|||||||||||||||||:.||||||||||||||
Frog  1382 IMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECA 1446

  Fly  1494 GEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYA--------SIIQQPI 1550
            ||||:||:.|:|.|::|||:||.|.||||||||:|||||.||::.:|..|        |..:.|.
Frog  1447 GEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLNPCADDVGLSDESCCRSPQ 1511

  Fly  1551 FCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVIL 1615
            ..|.::....:...:.||||:||||.|||||.|:.:|:.:|.||||:..|:|||||.|...|:||
Frog  1512 TLNCVNPENENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRPKAGDMDLEWRQGRMARIIL 1576

  Fly  1616 YDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKY------ETLN 1674
            .|||||:|.:::||:||||.||.|.||:.::|||||:|.||.|..|...:...:|      .|:.
Frog  1577 QDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYGHQLDHHTVG 1641

  Fly  1675 ISK------------------YTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERV 1721
            :.:                  .|:|||...|:.:|:.....|:|.:.|||||:||...|:||:|.
Frog  1642 LRRPVGRGQHQQADFWPESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRG 1706

  Fly  1722 NKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEV 1786
            :|:|||||||||||||||||||||||||||||||||||||||||||||||||:||..|.|||.:|
Frog  1707 SKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQITDYDV 1771

  Fly  1787 VHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLL 1851
            .||||||.||||||||:||||.|||||||::|.|:||||||||||||||||:|:|||||||:|||
Frog  1772 RHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLL 1836

  Fly  1852 YAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQL 1916
            ||||||.|:.||:|||.||..||.||||||:|.|||:||||.::||:..||||:|:|..||.:::
Frog  1837 YAKDIPNYKSWVERYYADIAKMSVISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYRDEI 1901

  Fly  1917 TVTLEEDEFSQKQRLAFKLEQVHNIMS 1943
            ...||:||.:::|||..|||||.:.|:
Frog  1902 LTALEKDEQARRQRLRSKLEQVIDTMA 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	173/473 (37%)
		PSI	522..574	CDD:279745	21/51 (41%)
		PSI	671..>699	CDD:279745	14/27 (52%)
		PSI	830..883	CDD:279745	15/55 (27%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/95 (37%)
		IPT_plexin_repeat2	978..1063	CDD:238584	21/84 (25%)
		IPT	1078..1177	CDD:301692	33/100 (33%)
		IPT_PCSR	1196..>1255	CDD:238337	19/62 (31%)
		Plexin_cytopl	1353..1916	CDD:285529	361/594 (61%)
plxna1	XP_031755564.1	Sema_plexin_A1	31..503	CDD:200532	174/477 (36%)
		PSI	504..554	CDD:396154	21/51 (41%)
		TIG_plexin	559..649	CDD:407808	22/95 (23%)
		PSI	650..697	CDD:396154	22/66 (33%)
		TIG_2	703..797	CDD:407859	23/93 (25%)
		PSI	799..851	CDD:396154	15/54 (28%)
		IPT_plexin_repeat1	853..948	CDD:238585	34/94 (36%)
		IPT_plexin_repeat2	950..1035	CDD:238584	22/85 (26%)
		IPT_plexin_repeat3	1037..1137	CDD:238586	36/112 (32%)
		TIG	1156..1223	CDD:396414	23/75 (31%)
		Plexin_cytopl	1307..1901	CDD:400574	361/594 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	705	1.000	Domainoid score	I123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1383	1.000	Inparanoid score	I130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	1	1.000	-	-		otm49109
Panther	1	1.100	-	-	O	PTHR22625
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160