DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and plxnb2a.2

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	NP_001107960.1	Gene:	plxnb2a.2 / 100034640	ZFINID:	ZDB-GENE-041210-159	Length:	477	Species:	Danio rerio

Alignment Length:	475	Identity:	135/475 - (28%)
Similarity:	212/475 - (44%)	Gaps:	79/475 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVS----IIEHEVPDAVVANDANSSTVAFIAP 194
            ||:||:|.::   |.||.||.||:|.|::.||.:|:    ..:.|.....||:...|.||..:
Zfish     2 DNFNKLLQVN---SVLIVCGILFRGICSLVNLNSVNKPVYYSDTEREKTWVASTEESVTVVGV-- 61

  Fly   195 GPPQHPVTNVMYVGVTYTN-------------NSPYRSEIPAVASRSLEKTKMFQIASSAVTTGT 246
                     :.|...|.||             :|.....|.....:...:..:|:....|.|...
Zfish    62 ---------ISYFKDTTTNANLSVFLVGKGFGSSDSSKLISTWLLQEHGEMDVFENMVEASTVQA 117

  Fly   247 RTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIP 311
            ..|::.|..:     :.|.|.:..:.|.|.:....:.||   ..||.:.|:.:.|.:||||||:.
Zfish   118 SAFVHRYHHD-----FRYTFKNNGYIYLLFSHTASTRHS---RKITFIARLSKNDHHYYSYTELQ 174

  Fly   312 VEC-ISDAQGGTKFNLVQAGFLGKPSSDLAQSLGIS-IQDDVLFAVFSKGEGNTPTNNSALCIYS 374
            :.| |:..|....||.|||.:|.||...|||::..| :.|.|||.|||..|.:   ..||||:|.
Zfish   175 LNCTINTEQQENTFNKVQAAYLAKPGKVLAQNIVPSNLNDKVLFGVFSADEED---GRSALCMYP 236

  Fly   375 LKSIRRKFMQNIKSCFNGSGMRGLDFISPSMP-CVLTKLQTIGEDFCGLDVNSPL------GGE- 431
            |.||..:|.:.|:||:.|      :.:....| .|.:...:..|..|....:..:      |.|
Zfish   237 LSSINARFEEVIESCYTG------EVLEDDKPKTVYSPYNSKNEAICRTKRDKNMVKAYICGAEF 295

  Fly   432 --TPITSVP--------VAMFNTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASF 486
              :|:.|.|        :...|..||:||....:.:||.|:|||...:.||.::.:     :..|
Zfish   296 LPSPLASKPEYALAVKLIYTGNDMLTAVAVAVENEHTVAFLGTSGADVLKVHLDPN-----HTDF 355

  Fly   487 -----AVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLE 546
                 ....|..:|:::.||....::|:.:..|:|||.|..|.....|..||..:|||||||..|
Zfish   356 YNRIPGQRTGGAVNKNLLFDTGLDHLYITTGRKISKVPVQVCGPKNDCRSCLIQQDPYCGWCVRE 420

  Fly   547 NKCSPRSNCQDDANDPLY-W 565
            .:|:.:.||.....:.:: |
Zfish   421 GRCTRKKNCNKGEGENVWLW 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	118/427 (28%)
		PSI	522..574	CDD:279745	16/45 (36%)
		PSI	671..>699	CDD:279745
		PSI	830..883	CDD:279745
		IPT_plexin_repeat1	885..977	CDD:238585
		IPT_plexin_repeat2	978..1063	CDD:238584
		IPT	1078..1177	CDD:301692
		IPT_PCSR	1196..>1255	CDD:238337
		Plexin_cytopl	1353..1916	CDD:285529
plxnb2a.2	NP_001107960.1	Sema	1..395	CDD:301699	118/428 (28%)
plxnb2a.2	NP_001107960.1	PSI	397..440	CDD:279745	15/42 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710