DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexA and mst1ra

DIOPT Version :9

Sequence 1:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster
Sequence 2:	XP_005166175.1	Gene:	mst1ra / 100002448	ZFINID:	ZDB-GENE-071218-2	Length:	1356	Species:	Danio rerio

Alignment Length:	1450	Identity:	283/1450 - (19%)
Similarity:	466/1450 - (32%)	Gaps:	493/1450 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QTLAANIWSDKTTAQNEPINLTNA--NAPIKNAKNLNSTIT-NVAAFDT--KLNHLLVDTITGRV 87
            :||....|..        |:||.|  ..|.....|:|.::| .|..|.|  .:.:::.:.....|
Zfish     6 KTLLTCFWLQ--------IHLTCAQKTCPTIQQMNVNFSVTYPVYFFQTTNAIQNIVFNEYFDEV 62

  Fly    88 FVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPL-NAVRSPTDNYNKVLLID--RATSRL 149
            :|...|.:..|..:|.....:||||.. |.:|...:|.: |...:..|..|:||:::  :....|
Zfish    63 YVASQNVVEALDKNLTKLWELKTGPVG-SPDCQTCNCDIENEPGTSLDTDNQVLVLEPQQHLDFL 126

  Fly   150 IACGSLFQGTCTVRNLQNVSIIEHEVPDAVVANDANS-STVAFIAPGPPQHPVTNV-----MYVG 208
            ..|||...|.|.:..|...:|...  |:.:....||| |........|....||.|     .|..
Zfish   127 YICGSTQYGVCNMLELDKGNIASS--PECLFNKKANSPSDCPDCVASPLGTKVTVVDEGYSTYFF 189

  Fly   209 VTYTNNSPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSY 273
            ...|.||....   :....||...::....:........|.:..: ::.:.::|:|.||:..:.|
Zfish   190 TAATVNSTIAG---SFGKHSLSIRRLLNTENGFHDVKNLTVLPKF-QDVFTIDYIYTFSTTEYVY 250

  Fly   274 FLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPVECISDAQGGTK------FNLVQAGFL 332
            ||:.|.:.....:.| ..|.|.|:..:||..:.|.||.:||..:.:...:      :|.|||...
Zfish   251 FLSVQWESLMKPNAK-LQTHLGRLPIKDSELWMYREIILECRFEPKRRRRSFRDVVYNSVQAAHF 314

  Fly   333 GKPSSDLAQSLGISIQDDVLFAVF--SKGEGNTPTNNSALCIYSLKSIRRKFMQNIKSCFNG--- 392
            .....:||..||:.|...:|:.||  :..:|| |...||||.:.|..:.....:.:.:|.:.
Zfish   315 STAGKELADDLGVRIDSPILYGVFAVTDQKGN-PMRQSALCAFPLDYVNSAIEKGVDACCSSLTE 378

  Fly   393 SGMRGLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVP-----VAMFNTKL-----T 447
            ...|||...   .||          :.|.::.:..|..:|..|.|.     |..||.::     |
Zfish   379 QISRGLCHF---QPC----------EMCPVENSDSLTCKTTPTMVSKPYYRVDFFNGQMSNVLFT 430

  Fly   448 SVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSK 512
            |:..|:....||..:||..|.|.:::: |.||...:|::::                    |...
Zfish   431 SILVTTIETKTVAHIGTDHGRLLQIIL-SRSIPVVFANYSL--------------------VEDA 474

  Fly   513 TKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTIT 577
            .|||::
Zfish   475 QKVSRI----------------------------------------------------------- 480

  Fly   578 SVVPHQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIE 642

Zfish   481 ----------------------------------------------------------------- 480

  Fly   643 QGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRN 707
                                         .:.|||                           ..:
Zfish   481 -----------------------------AAIHSS---------------------------LES 489

  Fly   708 DILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNI 772
            .:.|.|...|..|.| |||....:|
Zfish   490 LLFVVGNKLINVSPR-GPGCSHFLN---------------------------------------- 513

  Fly   773 EGRVTSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADS 837

Zfish   514 ----------------------------------------------------------------- 513

  Fly   838 CGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTN 902
            |..|||......||||.  ..|..:.||.....|        :.|| |.|..|.|:|.|..|.:.
Zfish   514 CSACLAAPRFMGCGWCG--EVCSQQHQCEDQWSG--------DSCP-PVITQFFPRTVPSNGTSE 567

  Fly   903 ITIRGINLGKNYNDIYS----GVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIG 963
            :.:.|.|.........:    .||:...:|...|: ...:..:||.:......::::..|.:|:.
Zfish   568 LILCGWNFQSASRPAITQESHQVRVGNSDCTVVPE-KTSSSLLVCRIVGEESGLHQSVNITIQVN 631

  Fly   964 DYRGESK---------EDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASIND-HLP 1018
            :.:..|.         :.:.||.|:|.|.:|.|||..|||.|.::||||:||.....|:.| :.|
Zfish   632 EKKAGSGYFISGKAGIQGFSFVTPEITDISPSFGPKIGGTLITLSGKHLDAGGSRTISLGDRNCP 696

  Fly  1019 CKILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK 1083
            .:.:|:|.:..:||:......:|..:|:..| |....:...|.|.::|.|..|:  |:...:
Zfish   697 VESVSSDGTSIVCRSEGVKDTLEVDVKVVID-GSTISSTKTFSYRVNPEVTGVN--PNCGFR--- 755

  Fly  1084 GIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASP----CRVQSD-TEMECASPVVDVDSHVIE 1143
                .|.:|.:||....|:.  ...:.|.|. |..|    |..|.: |:|||.|||.:..:.::.
Zfish   756 ----RGSKIIITGQNLDSVS--QAVIKYKGG-YKDPVETVCSGQGNPTQMECMSPVCEESTGILS 813

  Fly  1144 AERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFE------------ERVKYFKSEYL 1196
            .:          :|....:|:.:      |..:.|.|...||            :.|.....:..
Zfish   814 VD----------LDGAKDLQSQT------FTCHANGEPIPFETEDRVLELSPGQDEVSLHHKKLA 862

  Fly  1197 TINGRNLDRACKESDVEVKIGNGF-CNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEY 1260
            .::|      |.|..:.|   ||. ||...|. .::|||.|...|..:  .|..|.|.:... |:
Zfish   863 LVSG------CMEIIMTV---NGVDCNAKVLD-NEITCRIPKNLTIPR--QGAPVKVLVNRE-EH 914

  Fly  1261 RIGILSYESSNIILDWGENVIFAVIATI-VILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILE 1324
            .||::..::||:|:    .|:..::|.: |...:::||:....|||.:....|..:|.......|
Zfish   915 DIGMVVMKNSNLIV----GVVLGILAAVGVGAAIVYVAMAQERKKKKAALVEVRLSMHSNRTTAE 975

  Fly  1325 --------------LRVAAECKEAFAELQTEMTDL--TGDLTSGGIPFLDYRSYAMKILFPNHED 1373
                          :|.|......|....|..|.|  .|.:.|...|.: .|..:|..|
Zfish   976 NYDRSPDGDYRRETVRPAGLSVSPFHGSGTTFTSLPYAGSMDSAAAPLM-RRQVSMSAL------ 1033

  Fly  1374 HIVLQWERPELLRKEKGLRI 1393
                   ||:||.:.|.:.|
Zfish  1034 -------RPDLLEEVKNVLI 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	111/474 (23%)
		PSI	522..574	CDD:279745	0/51 (0%)
		PSI	671..>699	CDD:279745	3/27 (11%)
		PSI	830..883	CDD:279745	12/52 (23%)
		IPT_plexin_repeat1	885..977	CDD:238585	19/104 (18%)
		IPT_plexin_repeat2	978..1063	CDD:238584	29/85 (34%)
		IPT	1078..1177	CDD:301692	21/103 (20%)
		IPT_PCSR	1196..>1255	CDD:238337	17/59 (29%)
		Plexin_cytopl	1353..1916	CDD:285529	9/40 (23%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509	121/685 (18%)
		PSI	507..>547	CDD:307546	14/154 (9%)
		IPT	550..654	CDD:326624	19/104 (18%)
		IPT_plexin_repeat2	655..740	CDD:238584	29/85 (34%)
		IPT	742..828	CDD:214657	24/113 (21%)
		PTKc_Met_Ron	1057..1318	CDD:270649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11125
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810