DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbeta and KDM5A

DIOPT Version :9

Sequence 1:	NP_001259081.1	Gene:	ATPsynbeta / 43829	FlyBaseID:	FBgn0010217	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001036068.1	Gene:	KDM5A / 5927	HGNCID:	9886	Length:	1690	Species:	Homo sapiens

Alignment Length:	290	Identity:	60/290 - (20%)
Similarity:	103/290 - (35%)	Gaps:	91/290 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PPILNALEVDNRSPRLVLEVAQHLGENTVRT-IAMDGTEGLVRGQKVLDTGYPIRIPVGAETLGR 126
            ||....::....:||:     |.|.|....| :.:|..:.|.:..::  .|..::|||
Human    59 PPFACEVKSFRFTPRV-----QRLNELEAMTRVRLDFLDQLAKFWEL--QGSTLKIPV------- 109

  Fly   127 IINVIGEPIDERGPIDTDKTAAIHAEAPEFVQMSVEQEILVTGIKVVDLLAPYAK-GGKIGLFGG 190
                     .||..:|....:.|.|....|..::.|::              ::| |.::|...|
Human   110 ---------VERKILDLYALSKIVASKGGFEMVTKEKK--------------WSKVGSRLGYLPG 151

  Fly   191 AGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLY-NEMIEGGV---------ISLKDKT 245
            .|.|          ::.|:|  |       ||.     || .|:.:.||         :.||:|.
Human   152 KGTG----------SLLKSH--Y-------ERI-----LYPYELFQSGVSLMGVQMPNLDLKEKV 192

  Fly   246 SKVALVYGQMNEP-PGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIP 309
            ....|.......| ||.|..: |...|.....:.:.|        ::.|.|:.  :...:.|..|
Human   193 EPEVLSTDTQTSPEPGTRMNI-LPKRTRRVKTQSESG--------DVSRNTEL--KKLQIFGAGP 246

  Fly   310 SAVGYQPTLATDMGSMQERITTTKKGSITS 339
            ..||    ||  ||:..:....|::..:|:
Human   247 KVVG----LA--MGTKDKEDEVTRRRKVTN 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbeta	NP_001259081.1	PRK09280	44..507	CDD:236447	60/290 (21%)
		ATP-synt_ab_N	46..112	CDD:280947	10/49 (20%)
		F1-ATPase_beta	114..393	CDD:238553	49/238 (21%)
		ATP-synt_ab_C	401..508	CDD:278722
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	60/290 (21%)
		ARID	85..170	CDD:198082	26/140 (19%)
		PHD1_KDM5A	295..343	CDD:277075
		GSGFP motif. /evidence=ECO:0000250\|UniProtKB:Q3UXZ9	419..423
		JmjC	470..586	CDD:202224
		zf-C5HC2	676..728	CDD:280996
		PLU-1	741..1070	CDD:285609
		PHD2_KDM5A	1163..1215	CDD:277079
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1516..1543
		PHD3_KDM5A	1608..1659	CDD:277156
		Interaction with LMO2. /evidence=ECO:0000269\|PubMed:9129143	1623..1690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900