DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbeta and Vha68-3

DIOPT Version :9

Sequence 1:	NP_001259081.1	Gene:	ATPsynbeta / 43829	FlyBaseID:	FBgn0010217	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	128/535 - (23%)
Similarity:	212/535 - (39%)	Gaps:	154/535 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AANGKIVAVIGAVVDVQFDDNLPPILNALEVDNRSPRLVLEV--AQHLG-----ENTVRTIAM-D 97
            |..|:|..|.|            |::||.|:...:...::.|  :|.:|     |..:.||.: :
  Fly   138 ATMGRIFGVSG------------PVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYE 190

  Fly    98 GTEGLVRGQKVLDTGYPIRIPVGAETLGRIINVIGEPIDE-----------RGPIDTD------- 144
            .|.|:..|..|..||.|:.:.:|...:|.|.:.|..|:..           :| |||.
  Fly   191 DTSGVSVGDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKG-IDTPSLPRNIA 254

  Fly   145 ------------------------KTAAIHAE---------------APE--------FVQMSVE 162
                                    :.:.:|..               ||.        .|:....
  Fly   255 YEFTPGKLKIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFN 319

  Fly   163 QEI--------------------------LVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIME 201
            .||                          |:||.:|:|...|..:||...:.|..|.||||
  Fly   320 DEITKHTMLQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTV---- 380

  Fly   202 LINNVAKAHGGYS-----VFAGVGERTREGNDLYNEM------IEGGVISLKDKTSKVALVYGQM 255
                :::|...||     ::.|.|||..|.:::..:.      :.|.:.|:..:|   |||....
  Fly   381 ----ISQALSKYSNSDVIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRT---ALVANTS 438

  Fly   256 NEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAT 320
            |.|..||.....||:|::|||||. |..|.:..|:..|:.:|..|:|..|..:|:..||...|..
  Fly   439 NMPVAAREASIYTGITLSEYFRDM-GYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGA 502

  Fly   321 DMGSMQERITTTK-------KGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIY 378
            .:.|..||....|       :||::.|.|:..|..|.:||..:.|.:.:.....|.:.:|:...:
  Fly   503 RLASFYERAGLVKCLGSPDREGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHF 567

  Fly   379 PAVDPLDSTSRIM--------DPNIIGQEHYNVARGVQKILQDYKSLQDIIAILGMDELSEEDKL 435
            |:|:.|.|.|:.|        :.|   .|..::....:|:||:...|.:|:.::|...|:||||:
  Fly   568 PSVNWLQSYSKYMRTLDTYYEESN---PEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKI 629

  Fly   436 TVARARKIQ-RFLSQ 449
            |:..|:.:: .||.|
  Fly   630 TLEVAKMLKDDFLQQ 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbeta	NP_001259081.1	PRK09280	44..507	CDD:236447	127/532 (24%)
		ATP-synt_ab_N	46..112	CDD:280947	17/73 (23%)
		F1-ATPase_beta	114..393	CDD:238553	89/395 (23%)
		ATP-synt_ab_C	401..508	CDD:278722	16/50 (32%)
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	127/532 (24%)
		ATP-synt_ab_N	143..205	CDD:280947	17/73 (23%)
		V_A-ATPase_A	207..579	CDD:238554	88/384 (23%)
		ATP-synt_ab_C	597..738	CDD:278722	16/48 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840