DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbeta and KDM6B

DIOPT Version :9

Sequence 1:	NP_001259081.1	Gene:	ATPsynbeta / 43829	FlyBaseID:	FBgn0010217	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001073893.1	Gene:	KDM6B / 23135	HGNCID:	29012	Length:	1682	Species:	Homo sapiens

Alignment Length:	177	Identity:	37/177 - (20%)
Similarity:	54/177 - (30%)	Gaps:	47/177 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 GVGERTREGNDLYNEMIEGGVISLKDKTSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQ 282
            ||||....|..|:    :.....|:|          |..||  |..::...||.
Human   659 GVGELPARGPRLF----DFPPTPLED----------QFEEP--AEFKILPDGLA----------- 696

  Fly   283 DVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGSMQERITTTKKGSITSVQAIYVPA 347
            :::..:|...|..:...:..|       .|..||.|.....|:|....|.             .|
Human   697 NIMKMLDESIRKEEEQQQHEA-------GVAPQPPLKEPFASLQSPFPTD-------------TA 741

  Fly   348 DDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPN 394
            ...|.||.|.|......||..:....|....||:.|....::...|:
Human   742 PTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbeta	NP_001259081.1	PRK09280	44..507	CDD:236447	37/177 (21%)
		ATP-synt_ab_N	46..112	CDD:280947
		F1-ATPase_beta	114..393	CDD:238553	36/174 (21%)
		ATP-synt_ab_C	401..508	CDD:278722
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..680		7/24 (29%)
		Mito_fiss_reg	<566..640	CDD:283069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..807		22/105 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..1096
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1325
		JmjC	1343..1407	CDD:214721
		JmjC	1377..1485	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900