DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPsynbeta and KDM5B

DIOPT Version :9

Sequence 1:	NP_001259081.1	Gene:	ATPsynbeta / 43829	FlyBaseID:	FBgn0010217	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001300971.1	Gene:	KDM5B / 10765	HGNCID:	18039	Length:	1580	Species:	Homo sapiens

Alignment Length:	476	Identity:	97/476 - (20%)
Similarity:	167/476 - (35%)	Gaps:	130/476 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DKNLLPFLGQLSTAPFSARSHAAKAAKAAAAANGKIVAVIGAVVDVQFDDNLPPILNALEVDNRS 75
            |...|..|| :..||:||      ..||.|.....:      .|...:||....:|.|      .
Human   973 DMRRLIDLG-VGLAPYSA------VEKAMARLQELL------TVSEHWDDKAKSLLKA------R 1018

  Fly    76 PRLVL-----------EVAQHLG-----ENTVRTIA--MDGTEGLVRGQK--VLDTGYPI----- 115
            ||..|           |:..:|.     :::|:...  :...|||..|.:  ||||...:
Human  1019 PRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGR 1083

  Fly   116 RIPVGAETLGRIINVIGEPIDERGPIDTDKTAAIHAEAPEFVQMSVEQEILVTGIKVVDLLAPYA 180
            .|||...:|.|:..::.|       :...|..|::....|....|           ::::|.|..
Human  1084 SIPVHLNSLPRLETLVAE-------VQAWKECAVNTFLTENSPYS-----------LLEVLCPRC 1130

  Fly   181 KGGKIGL------------FGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGE-RTREGNDLYNE 232
            ..|.:||            .|.....|...:.:|...:.::....|..|.:|| |.||...|.:.
Human  1131 DIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSL 1195

  Fly   233 MI--EGGVIS-LKDKTSKVALVYGQMNEPPGA-------------RARVALTGLT------VAEY 275
            .:  ||.::| |:|...|:.|    ..:.|.|             .:.||:..::      :..:
Human  1196 RLANEGKLLSPLQDVDIKICL----CQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPH 1256

  Fly   276 FRDQEG---QDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGS-----MQERITT- 331
            .|..|.   :.:|..:.::.|......|..||...|...|.:|......:.|     :|:|:.:
Human  1257 CRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSG 1321

  Fly   332 -------TKKGSITSVQAIYVPADDLTDPAP-----ATTFAHLDATTVLSRAIAEL-GIYPAVDP 383
                   ...|.::....:..|....:...|     .|::.|...:|  .|:...| |:.|.|:.
Human  1322 LLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFST--GRSCIPLHGVSPEVNE 1384

  Fly   384 LDSTSRIMD---PNIIGQEHY 401
            |...::::.   |.|  ||.|
Human  1385 LLMEAQLLQVSLPEI--QELY 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbeta	NP_001259081.1	PRK09280	44..507	CDD:236447	86/443 (19%)
		ATP-synt_ab_N	46..112	CDD:280947	18/85 (21%)
		F1-ATPase_beta	114..393	CDD:238553	62/343 (18%)
		ATP-synt_ab_C	401..508	CDD:278722	1/1 (100%)
KDM5B	NP_001300971.1	JmjN	31..72	CDD:128818
		BRIGHT	98..188	CDD:128777
		PHD1_KDM5B	347..392	CDD:277076
		JmjC	522..638	CDD:202224
		zf-C5HC2	728..780	CDD:280996
		PLU-1	793..1122	CDD:285609	40/185 (22%)
		PHD2_KDM5B	1214..1257	CDD:277080	5/46 (11%)
		PHD3_KDM5B	1522..1571	CDD:277157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900