DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and CASK

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001354650.1	Gene:	CASK / 8573	HGNCID:	1497	Length:	926	Species:	Homo sapiens

Alignment Length:	587	Identity:	191/587 - (32%)
Similarity:	291/587 - (49%)	Gaps:	92/587 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR---DFQKLEREARICRKLHHP 71
            |.|.|::.|.:|||.||:|:||:.:.||.:||.||::..|.|:.   ..:.|:|||.||..|.||
Human     8 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHP 72

  Fly    72 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVARE----FYSEADASHCIQQILESVNHCHQNGV 132
            :||.|.::...:...|:||:.:.|.:|..:||.|.    .||||.|||.::||||::.:||.|.:
Human    73 HIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNI 137

  Fly   133 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            :|||:||..:|||||...|.|||..||:||::........|..|||.:::|||:|:|||||.||:
Human   138 IHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDV 202

  Fly   198 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRIT 262
            |.|||||:|||.|..||:. .:.||:..|..|.|.....:|..::..||:|:.:||.::|.:|||
Human   203 WGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT 266

  Fly   263 AAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR-------------NF 314
            ..|||.|||:.:|:|.|..:|..|||:.|:|||||||||||:|..:.:.:             :|
Human   267 VYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDF 331

  Fly   315 S----SRSMITKKGEGSQVKES-------TDSSSTTL-------EDDDIKE-----DKKGTVDRS 356
            |    |..::..:...|||.:|       ||.|...|       :|..:..     ||..|  :|
Human   332 SEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINT--KS 394

  Fly   357 TTVVSKEPEDI-----RILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKI 416
            :..:...|.|.     .:|.....|.:|       :.|:..:.|......:..:.:.|...:...
Human   395 SPQIRNPPSDAVQRAKEVLEEISCYPEN-------NDAKELKRILTQPHFMALLQTHDVVAHEVY 452

  Fly   417 CD-----------PHLTAFEPE-ALGNL-------VEGIDFHKFYFENVLGKNCKAINTTILNPH 462
            .|           |:|....|| |.|::       |..:.|.| ..:..:|...|      :|..
Human   453 SDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQK-NTDEPMGITLK------MNEL 510

  Fly   463 VHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISGATTFDF 527
            .|.:      :|.:.....|.:||..|.  .:|.|..:......|.|...:....::.|:.||..
Human   511 NHCI------VARIMHGGMIHRQGTLHV--GDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567

  Fly   528 IP 529
            :|
Human   568 VP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	136/297 (46%)
		S_TKc	14..272	CDD:214567	117/264 (44%)
		CaMKII_AD	390..517	CDD:285524	25/145 (17%)
CASK	NP_001354650.1	STKc_CASK	8..307	CDD:270996	137/299 (46%)
		Calmodulin-binding	305..315		4/9 (44%)
		L27	348..401	CDD:197794	13/54 (24%)
		L27	406..456	CDD:397114	7/56 (13%)
		Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250\|UniProtKB:Q62915	482..909		20/103 (19%)
		PDZ_signaling	488..568	CDD:238492	19/94 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..610
		SH3_CASK	616..677	CDD:213014
		Guanylate_kin	738..911	CDD:395500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910