DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and DCLK3

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001381601.1	Gene:	DCLK3 / 85443	HGNCID:	19005	Length:	817	Species:	Homo sapiens

Alignment Length:	279	Identity:	111/279 - (39%)
Similarity:	173/279 - (62%)	Gaps:	8/279 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 77
            :|:....:|.|.|::||.|..:.|...:|.|||:..:|..:: ..::.|..|.:.|.|||||:||
Human   524 HYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-DMVDSEILIIQSLSHPNIVKLH 587

  Fly    78 DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENL 142
            :..:.:...||:.:.|.||:||:.|:....:.|.||:..|..:.:::.|.|...:||||||||||
Human   588 EVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENL 652

  Fly   143 LL-ASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            |: .::.|...:||||||||..|.   :..|...|||.|::||:|.::.||..||:||.||||||
Human   653 LVQRNEDKSTTLKLADFGLAKHVV---RPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI 714

  Fly   207 LLVGYPPFW--DEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||.|:|||.  :.||..|::.|:.|.:::..|.||.::..||:|::::|.|:|.||.||.:.|:|
Human   715 LLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQH 779

  Fly   270 PWICQRERVASVVHRQETV 288
            ||| :.....:.|.||:.|
Human   780 PWI-ETAGKTNTVKRQKQV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	111/279 (40%)
		S_TKc	14..272	CDD:214567	105/260 (40%)
		CaMKII_AD	390..517	CDD:285524
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
DCLK3	NP_001381601.1	STKc_DCKL3	524..781	CDD:271087	104/260 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920