DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and CAMK1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_005265573.1	Gene:	CAMK1 / 8536	HGNCID:	1459	Length:	413	Species:	Homo sapiens

Alignment Length:	315	Identity:	126/315 - (40%)
Similarity:	186/315 - (59%)	Gaps:	3/315 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRL 76
            |.||.::.||.||||.|.....|.|....|.|.|..:.|..:: ..:|.|..:..|:.|||||.|
Human    18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE-GSMENEIAVLHKIKHPNIVAL 81

  Fly    77 HDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPEN 141
            .|..:...:.||:..||:|||||:.||.:.||:|.|||..|.|:|::|.:.|..|:|||||||||
Human    82 DDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPEN 146

  Fly   142 LLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            ||..|..:.:.:.::||||: :::..........|||||::||||.::||.|:||.|:.|||.||
Human   147 LLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYI 210

  Fly   207 LLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW 271
            ||.|||||:||:..:|:.||....|::.||.||.::..||:.|..::..:|.||.|..:||:|||
Human   211 LLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275

  Fly   272 ICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEG 326
            |.....:...:| |...:.:||..|:.|.|.|...|.:.......:...:::|:|
Human   276 IAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQG 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	122/290 (42%)
		S_TKc	14..272	CDD:214567	112/257 (44%)
		CaMKII_AD	390..517	CDD:285524
CAMK1	XP_005265573.1	STKc_CaMKI_alpha	16..278	CDD:271069	115/261 (44%)
CAMK1	XP_005265573.1	S_TKc	20..276	CDD:214567	112/257 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920