DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and CDPK2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_174807.1	Gene:	CDPK2 / 840471	AraportID:	AT1G35670	Length:	495	Species:	Arabidopsis thaliana

Alignment Length:	483	Identity:	159/483 - (32%)
Similarity:	231/483 - (47%)	Gaps:	85/483 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRK 67
            |....|..|:|.:.::||:|.|.....|.:|||...:|.|.|..:||..| |::.:.||.:|...
plant    16 PYQTPRLRDHYLLGKKLGQGQFGTTYLCTEKSTSANYACKSIPKRKLVCREDYEDVWREIQIMHH 80

  Fly    68 L-HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 131
            | .|||:||:..:.::..:.::|.::..|||||:.||::..:||.:|...|:.||..|..||..|
plant    81 LSEHPNVVRIKGTYEDSVFVHIVMEVCEGGELFDRIVSKGHFSEREAVKLIKTILGVVEACHSLG 145

  Fly   132 VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVD 196
            |:||||||||.|..|....|.:|..||||::..: ..|..:...|:|.|::|||||| .||..:|
plant   146 VMHRDLKPENFLFDSPKDDAKLKATDFGLSVFYK-PGQYLYDVVGSPYYVAPEVLKK-CYGPEID 208

  Fly   197 IWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRI 261
            :|:.||||||||.|.||||.|.:..::.||..|..|:.|..|.|::..||:||.:||..:|.|||
plant   209 VWSAGVILYILLSGVPPFWAETESGIFRQILQGKLDFKSDPWPTISEAAKDLIYKMLERSPKKRI 273

  Fly   262 TAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEG 326
            :|.|||.||||...:...........:..||:|:...|:|      .:|.|..:.|   ..:.|.
plant   274 SAHEALCHPWIVDEQAAPDKPLDPAVLSRLKQFSQMNKIK------KMALRVIAER---LSEEEI 329

  Fly   327 SQVKE-----STDSSST---------------TLEDDDIKE-------DKKGTVDRSTTVVSKEP 364
            ..:||     .||:|.|               .|.:.:||.       |..||:|
plant   330 GGLKELFKMIDTDNSGTITFEELKAGLKRVGSELMESEIKSLMDAADIDNSGTID---------- 384

  Fly   365 EDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFD--GYTKI----------- 416
                       |.:.:..:...:...|:      |.|:.|.:..|.|  ||..|
plant   385 -----------YGEFLAATLHMNKMERE------ENLVAAFSYFDKDGSGYITIDELQSACTEFG 432

  Fly   417 -CDPHLTAFEPEA-LGNLVEG-IDFHKF 441
             ||..|.....|. |.|  :| |||.:|
plant   433 LCDTPLDDMIKEIDLDN--DGKIDFSEF 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	119/292 (41%)
		S_TKc	14..272	CDD:214567	111/259 (43%)
		CaMKII_AD	390..517	CDD:285524	20/68 (29%)
CDPK2	NP_174807.1	STKc_CAMK	25..283	CDD:270687	110/259 (42%)
		Pkinase	26..284	CDD:278497	111/259 (43%)
		PTZ00184	320..462	CDD:185504	36/171 (21%)
		EFh	332..391	CDD:238008	14/79 (18%)
		EFh	404..463	CDD:238008	18/57 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm971
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.970