DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and CDPK9

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_197748.1	Gene:	CDPK9 / 832424	AraportID:	AT5G23580	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	385	Identity:	139/385 - (36%)
Similarity:	205/385 - (53%)	Gaps:	50/385 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRK 67
            |.......|||.:.:.||:|.|.....|..|.||.:.|.|.|..:||..: |:..:.||.:|
plant    12 PYKTKNVEDNYFLGQVLGQGQFGTTFLCTHKQTGQKLACKSIPKRKLLCQEDYDDVLREIQI--- 73

  Fly    68 LHH----PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 128
            :||    ||:||:..:.::....:||.:|..|||||:.||.|..|||.:|:..|:.|:..|..||
plant    74 MHHLSEYPNVVRIESAYEDTKNVHLVMELCEGGELFDRIVKRGHYSEREAAKLIKTIVGVVEACH 138

  Fly   129 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGK 193
            ..|||||||||||.|.:|..:.|::|..||||::... ..:|:....|:..|::||||.|. ||.
plant   139 SLGVVHRDLKPENFLFSSSDEDASLKSTDFGLSVFCT-PGEAFSELVGSAYYVAPEVLHKH-YGP 201

  Fly   194 SVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPN 258
            ..|:|:.||||||||.|:||||.|.:..::.:|..|..::....|.:::..||:||.:||..||.
plant   202 ECDVWSAGVILYILLCGFPPFWAESEIGIFRKILQGKLEFEINPWPSISESAKDLIKKMLESNPK 266

  Fly   259 KRITAAEALKHPWICQRERVASVVHRQETVDC-----LKKFNARRKLKGAILTTMLATRNFSSR- 317
            ||:||.:.|.||||.. ::||.    .:.:||     ||||:|..|||      .:|.|..:.|
plant   267 KRLTAHQVLCHPWIVD-DKVAP----DKPLDCAVVSRLKKFSAMNKLK------KMALRVIAERL 320

  Fly   318 ------------SMITKKGEGS----QVKESTDSSSTTLEDDDIKE-------DKKGTVD 354
                        .||.....|:    ::|:|.....:.|.:.:|:|       |:.||:|
plant   321 SEEEIGGLKELFKMIDTDKSGTITFEELKDSMRRVGSELMESEIQELLRAADVDESGTID 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	123/300 (41%)
		S_TKc	14..272	CDD:214567	107/262 (41%)
		CaMKII_AD	390..517	CDD:285524
CDPK9	NP_197748.1	STKc_CAMK	21..279	CDD:270687	107/262 (41%)
		Pkinase	22..280	CDD:278497	107/262 (41%)
		PTZ00184	316..458	CDD:185504	13/65 (20%)
		EFh	328..387	CDD:238008	12/53 (23%)
		EFh	400..459	CDD:238008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm971
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970