DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and CPK26

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001190949.1	Gene:	CPK26 / 829980	AraportID:	AT4G38230	Length:	514	Species:	Arabidopsis thaliana

Alignment Length:	501	Identity:	157/501 - (31%)
Similarity:	248/501 - (49%)	Gaps:	95/501 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRKLHH----P 71
            |.|.:..:||:|.|.....|.:.|||.|:|.|.|..:||.:: |.:.:.||.:|   :||    .
plant    52 DLYSLGHKLGQGQFGTTYMCKEISTGREYACKSITKRKLISKEDVEDVRREIQI---MHHLAGYK 113

  Fly    72 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRD 136
            |||.:..:.::..|.::|.:|.:|||||:.|:.|..|||..|:..|:.|:..|..||..||:|||
plant   114 NIVTIKGAYEDPLYVHIVMELCSGGELFDRIIQRGHYSERKAAELIKIIVGVVEACHSLGVMHRD 178

  Fly   137 LKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACG 201
            |||||.||.:|....::|..||||::..: ..|.:....|:|.|::||||.|. ||...|:|..|
plant   179 LKPENFLLVNKDDDFSLKAIDFGLSVFFK-PGQIFEDVVGSPYYVAPEVLLKH-YGPEADVWTAG 241

  Fly   202 VILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEA 266
            ||||||:.|.||||.|.|..::..:..|..|:.|..|..::..|||||..||...|::|:||.:.
plant   242 VILYILVSGVPPFWAETQQGIFDAVLKGHIDFDSDPWPLISDSAKNLIRGMLCSRPSERLTAHQV 306

  Fly   267 LKHPWICQ------RERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGE 325
            |:|||||:      |....:|:.|      ||:|:|..|||...|..:       :.|:..::..
plant   307 LRHPWICENGVAPDRALDPAVLSR------LKQFSAMNKLKQMALRVI-------AESLSEEEIA 358

  Fly   326 GSQVKE-----STDSS---------------STTLEDDDIKE-------DKKGTVD-----RSTT 358
            |  :||     .||:|               .:||:|.:|::       ||.||:|     .:|.
plant   359 G--LKEMFKAMDTDNSGAITFDELKAGLRRYGSTLKDTEIRDLMEAADIDKSGTIDYGEFIAATI 421

  Fly   359 VVSKEPEDIRILCPAKTYQQN----IGNSQCSSAARRQEIIKI-TEQLIEAINSGDFDGYTKICD 418
            .::|...:..:|...:.:.::    |...:...|...|.:..: .|.:|:.::. |.||
plant   422 HLNKLEREEHLLSAFRYFDKDGSGYITIDELQHACAEQGMSDVFLEDVIKEVDQ-DNDG------ 479

  Fly   419 PHLTAFEPEALGNLVEGIDFHKFYF---ENVLGKNC-KAINTTILN 460
                            .||:.:|..   :.::|:.. |:||.:|.|
plant   480 ----------------RIDYGEFVAMMQKGIVGRTMRKSINMSIRN 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	120/301 (40%)
		S_TKc	14..272	CDD:214567	106/262 (40%)
		CaMKII_AD	390..517	CDD:285524	15/76 (20%)
CPK26	NP_001190949.1	Pkinase	54..312	CDD:278497	106/262 (40%)
		STKc_CAMK	54..311	CDD:270687	105/261 (40%)
		PTZ00184	348..490	CDD:185504	30/173 (17%)
		EFh	360..419	CDD:238008	14/58 (24%)
		EFh	431..491	CDD:238008	12/82 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm971
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970