DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and CPK13

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_190753.2	Gene:	CPK13 / 824348	AraportID:	AT3G51850	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	436	Identity:	144/436 - (33%)
Similarity:	222/436 - (50%)	Gaps:	62/436 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKL-TARDFQKLEREARICRKLHHP---N 72
            |.|.:..|||:|.|.:...|:::|:....|.|.|:.:|| ||.|.:.::||..|.:  |.|   :
plant    52 DRYLLDRELGRGEFGVTYLCIERSSRDLLACKSISKRKLRTAVDIEDVKREVAIMK--HLPKSSS 114

  Fly    73 IVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDL 137
            ||.|.::.:::|..:||.:|..|||||:.||||..|:|..|:...:.|:|.|..||::||:||||
plant   115 IVTLKEACEDDNAVHLVMELCEGGELFDRIVARGHYTERAAAGVTKTIVEVVQLCHKHGVIHRDL 179

  Fly   138 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGV 202
            ||||.|.|:|.:.:.:|..||||:|..: ..:.:....|:|.|::|||||:. ||..:|||:.||
plant   180 KPENFLFANKKENSPLKAIDFGLSIFFK-PGEKFSEIVGSPYYMAPEVLKRN-YGPEIDIWSAGV 242

  Fly   203 ILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            ||||||.|.||||.|.:..:...|..|..|:....|..::..||||:.|||..:|.:|:||.:.|
plant   243 ILYILLCGVPPFWAESEQGVAQAILRGVIDFKREPWPNISETAKNLVRQMLEPDPKRRLTAKQVL 307

  Fly   268 KHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQV--- 329
            :||||...::..:|.........||:|:...:.|...|..:       :..:.|::.|..:|
plant   308 EHPWIQNAKKAPNVPLGDVVKSRLKQFSVMNRFKRKALRVI-------AEFLSTEEVEDIKVMFN 365

  Fly   330 KESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPA-----------------KTYQ 377
            |..||:....    .|:|.|.|..|.||.:...|   :::|..|                 ..:.
plant   366 KMDTDNDGIV----SIEELKAGLRDFSTQLAESE---VQMLIEAVDTKGKGTLDYGEFVAVSLHL 423

  Fly   378 QNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGY-----TKICD 418
            |.:.|.               |.|.:|.:..|.||.     .::||
plant   424 QKVAND---------------EHLRKAFSYFDKDGNGYILPQELCD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	117/294 (40%)
		S_TKc	14..272	CDD:214567	109/261 (42%)
		CaMKII_AD	390..517	CDD:285524	8/34 (24%)
CPK13	NP_190753.2	STKc_CAMK	53..311	CDD:270687	108/261 (41%)
		FRQ1	352..493	CDD:227455	26/125 (21%)
		EFh_PEF	470..>526	CDD:355382
		EF-hand motif	470..497	CDD:320054
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm971
orthoMCL	1	0.900	-	-		OOG6_100515
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870