DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and CPK20

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_181425.1	Gene:	CPK20 / 818476	AraportID:	AT2G38910	Length:	583	Species:	Arabidopsis thaliana

Alignment Length:	456	Identity:	144/456 - (31%)
Similarity:	222/456 - (48%)	Gaps:	68/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTA-RDFQKLEREARICRKLH-HPNIV 74
            |.|.:..:||:|.|.....||.|.||.|||.|.|..:|||. .|.:.:.||.:|...|. |||::
plant   132 DIYSVGRKLGQGQFGTTFLCVDKKTGKEFACKTIAKRKLTTPEDVEDVRREIQIMHHLSGHPNVI 196

  Fly    75 RLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKP 139
            ::..:.::....::|.::..|||||:.|:.|..|:|..|:...:.|:..:..||..||:||||||
plant   197 QIVGAYEDAVAVHVVMEICAGGELFDRIIQRGHYTEKKAAELARIIVGVIEACHSLGVMHRDLKP 261

  Fly   140 ENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVIL 204
            ||.|..|..:.||:|..||||::..: ..:.:....|:|.|::||||:|. |....|:|:.|||:
plant   262 ENFLFVSGDEEAALKTIDFGLSVFFK-PGETFTDVVGSPYYVAPEVLRKH-YSHECDVWSAGVII 324

  Fly   205 YILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||||.|.||||||.:..::.|:..|..|:.|..|.:|:..||:|:.:||..:|.||:|..|.|.|
plant   325 YILLSGVPPFWDETEQGIFEQVLKGDLDFISEPWPSVSESAKDLVRRMLIRDPKKRMTTHEVLCH 389

  Fly   270 PWICQRERV----------ASVVHRQETVDCLKKFNARRKLKG---AILTTMLATRNFSSR---- 317
            ||    .||          ::|:.|      |::|:|..|||.   .::...|:....:..
plant   390 PW----ARVDGVALDKPLDSAVLSR------LQQFSAMNKLKKIAIKVIAESLSEEEIAGLKEMF 444

  Fly   318 SMITKKGEG----SQVKESTDSSSTTLEDDDI-------KEDKKGTVDRSTTVVSK------EPE 365
            .||.....|    .::|:..|.....|:|.:|       ..|..||:|....:.:.      |.|
plant   445 KMIDTDNSGHITLEELKKGLDRVGADLKDSEILGLMQAADIDNSGTIDYGEFIAAMVHLNKIEKE 509

  Fly   366 DIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQL-------------IEAINSGDFDGYTKIC 417
            |  .|..|.:|....|    |....|.|:.:..:|.             ::..|.|..| |::..
plant   510 D--HLFTAFSYFDQDG----SGYITRDELQQACKQFGLADVHLDDILREVDKDNDGRID-YSEFV 567

  Fly   418 D 418
            |
plant   568 D 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	115/305 (38%)
		S_TKc	14..272	CDD:214567	103/259 (40%)
		CaMKII_AD	390..517	CDD:285524	8/42 (19%)
CPK20	NP_181425.1	STKc_CAMK	134..391	CDD:270687	102/258 (40%)
CPK20	NP_181425.1	FRQ1	432..572	CDD:227455	29/144 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm971
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.970