Protein Alignment CaMKII and CAMK2D

DIOPT Version :10

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 385/551 - (69%)
• Similarity: 433/551 - (78%)
• Gaps: 74/551 - (13%)

  Fly     1 MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARIC 65
            ||:...||||:|.|.:.|||||||||:|:||::..||.|:||||||||||:|||.||||||||||
Human     1 MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65

  Fly    66 RKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 130
            |.|.|||||||||||.||.:|||||||||||||||||||||:|||||||||||||||||||||.|
Human    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130

  Fly   131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 195
            |:|||||||||||||||:|||||||||||||||||||.||||||||||||||||||:|:||||.|
Human   131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195

  Fly   196 DIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260
            |:||||||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||.||
Human   196 DMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKR 260

  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGE 325
            |||:|||||||||||..|||::|||||||||||||||||||||||||||||||||:...:.||.:
Human   261 ITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPD 325

  Fly   326 GSQV--------------------------------KESTDSSSTTLEDDDIKEDKKGTVDRSTT 358
            |.::                                ||||:||:||:||:|:|
Human   326 GVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVK------------ 378

  Fly   359 VVSKEPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTA 423
                                          ||:|||||:|||||||||:|||:.|||||||.|||
Human   379 ------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTA 413

  Fly   424 FEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHA 488
            ||||||||||||:|||:|||||.|.|:.|.|:|.||||||||:|::||||||:|||||:|..|..
Human   414 FEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMP 478

  Fly   489 HTHQSEETRVWHKRDNKWQNVHFHRSASAKI 519
            .|.|||||||||:||.||||||||||.|..:
Human   479 KTMQSEETRVWHRRDGKWQNVHFHRSGSPTV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		CaMKII_AD	390..517	CDD:285524	97/126 (77%)
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		CaMKII_AD	380..507	CDD:285524	97/126 (77%)