DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Camkv

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_076490.1	Gene:	Camkv / 79011	RGDID:	621488	Length:	504	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	141/477 - (29%)
Similarity:	227/477 - (47%)	Gaps:	81/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREAR----ICRKLHHP 71
            :|.||:.:.:....|..:.|...|:||     |:...||...||.:|:.:.|:    |.:.:.||
  Rat    21 TDRYDLGQVVKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHP 80

  Fly    72 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRD 136
            ||::|.|.......:::..:|.||.|:|:.|:.:.:|||.|.|:.::|:||:|.:.|...:|||:
  Rat    81 NILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRN 145

  Fly   137 LKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACG 201
            ||.|||:..::.|.:.:.::||.||....|..:.   ..|||.||:|||:.::.||:.||.||.|
  Rat   146 LKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVVGRQRYGRPVDCWAIG 207

  Fly   202 VILYILLVGYPPFWDE------DQH--RLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPN 258
            ||:||||.|.|||::|      :.|  .|:.:|.||.|::.||.||.::..||:|:.:::.|..:
  Rat   208 VIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQD 272

  Fly   259 KRITAAEALKHPWICQRERVASVVHRQETVDC--LKKFNARRKLKGAILTTMLATR--------- 312
            :||||.||:.|.||  ....||..:.::.| |  ::|..||.|.|.|:..|.|..|
  Rat   273 QRITAEEAISHEWI--SGNAASDKNIKDGV-CAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSGT 334

  Fly   313 --------------------------NFSSRSMITKKGEGSQVKE------------STDSSSTT 339
                                      :.:|.::.|....|...|.            :||.|:|.
  Rat   335 AATSDAATPGAAGGAVAAAAGGAAPASGASATVGTGGDAGCAAKSDDMASADRSATPATDGSATP 399

  Fly   340 LEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPA-------KTYQQNIGNSQCSSAARRQEIIKI 397
            ..|..:.....|::..:|. .|..|...|...||       .|.:..:..:| ||||...:....
  Rat   400 ATDGSVTPATDGSITPATD-GSVTPATDRSATPATDGRATPATEESTVPAAQ-SSAAPAAKAAAT 462

  Fly   398 TEQLIEAINSGDFDGYTKICDP 419
            .|..:...:|...:|.|....|
  Rat   463 PEPAVAQPDSTALEGATGQAPP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	110/304 (36%)
		S_TKc	14..272	CDD:214567	98/269 (36%)
		CaMKII_AD	390..517	CDD:285524	5/30 (17%)
Camkv	NP_076490.1	STKc_CaMK_like	22..286	CDD:270990	99/271 (37%)
		PRK12495	<368..>445	CDD:183558	16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..504		24/109 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920