DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and dclk1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_012812605.1	Gene:	dclk1 / 733926	XenbaseID:	XB-GENE-960590	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	127/347 - (36%)
Similarity:	191/347 - (55%)	Gaps:	18/347 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 75
            |:.|.:...:|.|.|:|||.|:::|||.|:|.||||..|...:: ..::.|..|.|::.|||||.
Frog   400 SERYKVGRTIGDGNFAIVKECIERSTGREYALKIINKSKCRGKE-HMIQNEVSILRRVKHPNIVL 463

  Fly    76 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPE 140
            |.:.:...:..|||.:||.||:||:.|.:...|:|.||:..:..::.::.:.|...:||||:|||
Frog   464 LIEEMDMPSELYLVMELVKGGDLFDAITSTNKYTERDANGMLYNLMSAIKYLHSLNIVHRDIKPE 528

  Fly   141 NLLLASKAKGA-AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVIL 204
            |||:.....|: ::||.|||||..|.|   ..:...|||.|::||::.:..||..|||||.|||.
Frog   529 NLLVYEHQDGSKSLKLGDFGLATVVDG---PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVIT 590

  Fly   205 YILLVGYPPF--WDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            ||||.|:|||  ..:||..|:.||..|..|:|||.||.|:..||.||..||.|:.::|.:|.:.|
Frog   591 YILLCGFPPFRGSGDDQEVLFDQILMGHMDFPSPYWDNVSDSAKELITMMLQVDVDQRYSALKVL 655

  Fly   268 KHPWI-----CQRERVASVVHRQETVDCLKKFNARRKLK-GAILTTMLATRNFSSRSMITKKGEG 326
            :|||:     .:.|...||..:.:     |.||...|.. .:....::||........:.::...
Frog   656 EHPWVNDDGLPENEYPLSVAGKIK-----KHFNTGPKPNCNSAGVNVIATTALDKERQVFRRRRN 715

  Fly   327 SQVKESTDSSSTTLEDDDIKED 348
            ..|:....|.....|.:...||
Frog   716 QDVRYRFGSHQAAPEFNSESED 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	119/299 (40%)
		S_TKc	14..272	CDD:214567	111/260 (43%)
		CaMKII_AD	390..517	CDD:285524
dclk1	XP_012812605.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		STKc_DCKL1	396..663	CDD:271085	113/266 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920