DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and Dclk2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001344389.1	Gene:	Dclk2 / 70762	MGIID:	1918012	Length:	772	Species:	Mus musculus

Alignment Length:	333	Identity:	125/333 - (37%)
Similarity:	186/333 - (55%)	Gaps:	11/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRL 76
            :.|.|.:.:|.|.|::||.||.:.||.|||.|||:..|...:: ..:|.|..|.|::.||||:.|
Mouse   407 EKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKE-HLIENEVSILRRVKHPNIIML 470

  Fly    77 HDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPEN 141
            .:.::.....:||.:||.||:||:.|.:...|:|.|.|..:..:..::.:.|...:||||:||||
Mouse   471 VEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPEN 535

  Fly   142 LLLASKAKGA-AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILY 205
            ||:.....|. ::||.|||||..|:|   ..:...|||.|::||::.:..||..||:||.|||.|
Mouse   536 LLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITY 597

  Fly   206 ILLVGYPPFWDED--QHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALK 268
            |||.|:|||..|:  |..|:.||.||..::|:|.||.:|..||.||:|||.||...|.||.|.|.
Mouse   598 ILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILS 662

  Fly   269 HPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKEST 333
            |||:.......:.:..:.|....:.||.....:.:..|.:....|    :.:.|:|:....|...
Mouse   663 HPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMN----TALDKEGQIFCSKLCQ 723

  Fly   334 DSSSTTLE 341
            |||..:.|
Mouse   724 DSSRPSRE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	116/293 (40%)
		S_TKc	14..272	CDD:214567	112/260 (43%)
		CaMKII_AD	390..517	CDD:285524
Dclk2	NP_001344389.1	DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		PKc_like	407..665	CDD:328722	111/261 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920