DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Stk33

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_008758045.2	Gene:	Stk33 / 690861	RGDID:	1590972	Length:	508	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	116/400 - (28%)
Similarity:	184/400 - (46%)	Gaps:	55/400 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD 78
            |.....||:|:|.:|.....|.||.::|.|.:|.:|..:...:.||||..|.:.:.|.:|:.|..
  Rat   112 YTFGRILGQGSFGMVIEATDKETGAKWAIKKVNKEKAGSSAVKLLEREVNILKTVKHQHIIHLEQ 176

  Fly    79 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLL 143
            ..:.....|||.:|...|||.|.:..|..:||::....||.:..::.:.|...:||||||.||::
  Rat   177 VFESPQKMYLVMELCEDGELKEVLDQRGHFSESETRLIIQSLASAIAYLHSKDIVHRDLKLENIM 241

  Fly   144 LAS------KAKGAAVKLADFGLAIEVQGDHQAWF--GFAGTPGYLSPEVLKKEPYGKSVDIWAC 200
            :.|      ......:|::|||||::..|......  ...|||.|::|||:....|.:..|||:.
  Rat   242 VKSSFIDDNNEMNLNIKVSDFGLAVQKHGSRSESMMQTTCGTPIYMAPEVINAHDYSQQCDIWSI 306

  Fly   201 GVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAE 265
            |||:||||.|.|||....:.:|:..|:.|...:..|.||:|:..||:.:.|::.|:|..||||.|
  Rat   307 GVIMYILLCGEPPFLANSEEKLFELIRKGELQFQDPVWDSVSDSAKSALKQLMKVDPAHRITAKE 371

  Fly   266 ALKHPWI----CQRERVASVV-------HRQETVDCLK-----KFNARRKLKGAILTTMLATRNF 314
            .|.:.|:    ....|..:|:       :..|:.|..|     :.:...|||
  Rat   372 LLDNQWLTGNTLSSARPTNVLEMMKEWKNNPESDDDTKADKETEQHTEEKLK------------- 423

  Fly   315 SSRSMITKKGEGSQVKESTDSSSTTLEDDDIKEDKKGTVDRS----------TTVVSKEPE---- 365
              .:.|.:|  ...|..|..:.|.....|:.|:....:||.|          :..:..|||
  Rat   424 --HNKIEEK--APNVNHSPSAKSVNQPTDEAKKPDADSVDMSPSDSTSYKLISAEIKAEPEKSSG 484

  Fly   366 DIRILCPAKT 375
            .:..:..|||
  Rat   485 SVSHVAVAKT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	100/312 (32%)
		S_TKc	14..272	CDD:214567	91/265 (34%)
		CaMKII_AD	390..517	CDD:285524
Stk33	XP_008758045.2	PKc_like	110..378	CDD:419665	91/265 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920