DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and STK33

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	419	Identity:	109/419 - (26%)
Similarity:	190/419 - (45%)	Gaps:	70/419 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD 78
            |.....||||:|.||.....|.|..::|.|.:|.:|..:...:.||||..|.:.:.|.:|:.|..
Human   116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQ 180

  Fly    79 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLL 143
            ..:.....|||.:|...|||.|.:..:..:||.:....||.:..::.:.|.|.:||||||.||::
Human   181 VFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIM 245

  Fly   144 LAS------KAKGAAVKLADFGLAIEVQGDHQAWF-GFAGTPGYLSPEVLKKEPYGKSVDIWACG 201
            :.|      ......:|:.|||||::.|...:|.. ...|||.|::|||:....|.:..|||:.|
Human   246 VKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIG 310

  Fly   202 VILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEA 266
            |::|:||.|.|||....:.:|:..|:.|...:.:..|::::..||:::.|::.|:|..||||.|.
Human   311 VVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKEL 375

  Fly   267 LKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKE 331
            |.:.|:...:  .|.|.....::.:|::                            |.....|:|
Human   376 LDNQWLTGNK--LSSVRPTNVLEMMKEW----------------------------KNNPESVEE 410

  Fly   332 STDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQ--NIGNSQCSSAARRQEI 394
            :|..          :::|..|.::                 .|:||.  |:.::..:|....::.
Human   411 NTTE----------EKNKPSTEEK-----------------LKSYQPWGNVPDANYTSDEEEEKQ 448

  Fly   395 IKITEQLIEAINSGDFDGYTKICDPHLTA 423
            ....|:...|.:..:||    :|....|:
Human   449 STAYEKQFPATSKDNFD----MCSSSFTS 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	92/295 (31%)
		S_TKc	14..272	CDD:214567	88/264 (33%)
		CaMKII_AD	390..517	CDD:285524	6/34 (18%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91
		STKc_STK33	114..381	CDD:270999	88/264 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468		15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920