DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and dclk2a

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001128593.1	Gene:	dclk2a / 572548	ZFINID:	ZDB-GENE-050420-170	Length:	810	Species:	Danio rerio

Alignment Length:	395	Identity:	138/395 - (34%)
Similarity:	202/395 - (51%)	Gaps:	49/395 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 70
            |.:...|.|.|.:.:|.|.|::||.||::|||.|||.|||:..|...:: ..:|.|..:.|::.|
Zfish   412 AASTILDKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKNKCRGKE-HLIENEVAVLRRVKH 475

  Fly    71 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHR 135
            |||:.|.:.:......|||.:||.||:||:.|.:...|:|.|||..:..:..::.:.|:..:|||
Zfish   476 PNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAALKYLHRMCIVHR 540

  Fly   136 DLKPENLLLASKAKGA-AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWA 199
            |:||||||:.....|. ::||.|||||..|:|   ..:...|||.|::||::.:..||..|||||
Zfish   541 DIKPENLLVCEYPNGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAESGYGLKVDIWA 602

  Fly   200 CGVILYILLVGYPPFWDED--QHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRIT 262
            .|||.||||.|:|||..|:  |..|:.||..|..::|||.||.::..||.||..||.||...|.|
Zfish   603 AGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHMLQVNVEARYT 667

  Fly   263 AAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGS 327
            |.:.|.|||:              |.|...:.|.:.::.|.:                 ||...|
Zfish   668 AEDVLSHPWV--------------TEDAAMENNMKMEVAGKL-----------------KKHFNS 701

  Fly   328 QVKESTDSS------STTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCS 386
            ..|:|..|:      :|.|:.:.|:...: ..||:.....|.|....   |.:. :.|.|.|...
Zfish   702 VQKQSNTSAGVSVIMNTALDKETIQLSHR-RQDRNPPRPEKRPSSTN---PERR-RSNRGRSSVQ 761

  Fly   387 SAARR 391
            |...|
Zfish   762 SEDSR 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	117/293 (40%)
		S_TKc	14..272	CDD:214567	112/260 (43%)
		CaMKII_AD	390..517	CDD:285524	1/2 (50%)
dclk2a	NP_001128593.1	DCX	59..149	CDD:214711
		DCX	186..274	CDD:214711
		STKc_DCKL2	418..676	CDD:271086	112/261 (43%)
		S_TKc	420..677	CDD:214567	112/260 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920