DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and pnck

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_021334045.1	Gene:	pnck / 567480	ZFINID:	ZDB-GENE-081105-127	Length:	333	Species:	Danio rerio

Alignment Length:	329	Identity:	126/329 - (38%)
Similarity:	189/329 - (57%)	Gaps:	21/329 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YDIKEELGKGAFSIVK----RCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIV 74
            |::||:||:|:||.|:    ||.||..    |.|.|..:.|..:: ..||.|..:.|:::|.|||
Zfish    17 YELKEKLGEGSFSEVRVAQHRCTQKLV----AVKCIRKRALKGKE-SMLENEVAVLRRINHENIV 76

  Fly    75 RLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKP 139
            .|.::.:.....|||..|:|||||...|:.|..|:|.|||..|.|:|::|.:.||.|||||||||
Zfish    77 SLEETFETPTKLYLVMTLLTGGELLNRILERGSYTEKDASRVIYQVLQAVKYLHQLGVVHRDLKP 141

  Fly   140 ENLLLASKAKGAAVKLADFGLA-IEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVI 203
            |||:..:..:.:.:.::||||: :|.||   |.....|||.|::||:|:::.|||.||:||.|||
Zfish   142 ENLIFETPLEDSKIVISDFGLSKMEEQG---ALSTACGTPAYVAPELLQQKTYGKEVDLWAIGVI 203

  Fly   204 LYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALK 268
            .:|||.|||||:|::..:||..|....|::.||.|:.::..||:.|..:|..:|.||....:|.:
Zfish   204 TFILLCGYPPFYDDNDTQLYKLIIKAEYEFDSPYWNDISDSAKDFIVHLLQKDPAKRFNCEQASQ 268

  Fly   269 HPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKEST 333
            ||||.....:...:|...:....|.| |:...|.|...|::...       :|||....:..|..
Zfish   269 HPWISGGAALDRNIHGSVSAQIQKNF-AKSHWKRAFNATIIVHH-------LTKKAHPGEDDEGN 325

  Fly   334 DSSS 337
            .|:|
Zfish   326 QSTS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	118/293 (40%)
		S_TKc	14..272	CDD:214567	111/262 (42%)
		CaMKII_AD	390..517	CDD:285524
pnck	XP_021334045.1	PKc_like	13..289	CDD:328722	114/279 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920