DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and si:ch211-27e6.1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_009305164.3	Gene:	si:ch211-27e6.1 / 566628	ZFINID:	ZDB-GENE-130530-569	Length:	434	Species:	Danio rerio

Alignment Length:	346	Identity:	113/346 - (32%)
Similarity:	174/346 - (50%)	Gaps:	43/346 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
            |.:..|:|:..:|:|:||.|.|...|.|...||.|:::.:  .....:..:.|.|:.|:::||||
Zfish    91 RVTARYEIQALIGRGSFSRVVRAEHKQTHQPFAIKLLDLR--APEGLESCQAELRVLRRVNHPNI 153

  Fly    74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLK 138
            :||.:..|..:..|||.:|.|||||.|.:::|..:.|.||:..:..:...:.:.|..||:|||||
Zfish   154 IRLTEVFQTPHRVYLVLELATGGELLERVLSRGTFRERDATKALLMVTSGLAYLHNLGVIHRDLK 218

  Fly   139 PENLLLASKAKGAAVKLADFGLAI---EVQGD---------HQAWF--GFAGTPGYLSPEVLKKE 189
            |||||.....:.:.:.:.|||||.   .:|.|         .:.|.  ...|||.||:||:|.:.
Zfish   219 PENLLYYHPGQDSRLIITDFGLACWDKSIQRDDLELTVGLEEKGWALRTLCGTPEYLAPEMLARR 283

  Fly   190 PYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLT 254
            ..|::||:||.|:|.|:||.|..||....:.:|:..|..|:|.:....|.:|:...|..||.:||
Zfish   284 GCGRAVDMWALGIITYVLLSGSLPFDHSSRAKLFRAILKGSYSFHGEPWRSVSSLGKGFINGLLT 348

  Fly   255 VNPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSM 319
            |.|.:|::|.|||.|||:.            ....|....|.:|.:          :||...|:.
Zfish   349 VVPEQRMSAEEALHHPWLV------------NMAACSSNKNLQRSI----------SRNLQRRAS 391

  Fly   320 IT-----KKGEGSQVKESTDS 335
            .|     ....|||...|:.|
Zfish   392 RTSSRCPSSASGSQASRSSSS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	103/304 (34%)
		S_TKc	14..272	CDD:214567	99/271 (37%)
		CaMKII_AD	390..517	CDD:285524
si:ch211-27e6.1	XP_009305164.3	PKc_like	94..366	CDD:328722	99/273 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920