DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and phkg1a

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001071080.1	Gene:	phkg1a / 565379	ZFINID:	ZDB-GENE-061103-385	Length:	394	Species:	Danio rerio

Alignment Length:	400	Identity:	134/400 - (33%)
Similarity:	208/400 - (52%)	Gaps:	43/400 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIIN---TKKLTARDFQKLE----REA 62
            |....|...||.||.||:|..|:|:||:.|.|..|:|.|:|:   :.|:...:.:::.    :|.
Zfish    11 AGAQDFYQKYDPKEILGRGVSSVVRRCIHKRTTQEYAVKVIDITPSDKMNTEEIEEIRNATIKEI 75

  Fly    63 RICRKL-HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNH 126
            .|.:|: ...||::|.|..:.:.:.:|||||:..||||:.:..:...||.:....::.:||.|..
Zfish    76 DILKKVCGQENIIQLKDCFETKAFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRSLLEVVQF 140

  Fly   127 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK---- 187
            .|...:|||||||||:||.....   :||.|||.|::: ...|......||||||:||:::
Zfish   141 LHSQNIVHRDLKPENILLDDNMN---IKLTDFGFAVQI-APGQKLNEVCGTPGYLAPEIIECSMD 201

  Fly   188 --KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLIN 250
              .:.||.:||:|:.|||::.||.|.||||...|..:...|.||.|.:.|||||..:...|:||:
Zfish   202 PHHQGYGAAVDLWSAGVIMFTLLAGSPPFWHRKQMLMLRMILAGNYQFTSPEWDDRSDTVKDLIS 266

  Fly   251 QMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR--- 312
            :||.|||.||.||.:||.||:. |:..||.|.|          |:..||.| .|..|:|||.
Zfish   267 KMLVVNPEKRFTATDALNHPFF-QQYVVAEVRH----------FSPYRKFK-VICMTVLATMRIY 319

  Fly   313 -NFSSRSMITKKGEGSQ------VKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRIL 370
             |:.....:||:...|.      :::..|:.:..:....:   |||.......:....|:.|.:.
Zfish   320 CNYRRAKPVTKEVIKSDPYAVKPIRKLIDACAFKIYGHWV---KKGQTQNRAALFENSPKAILLS 381

  Fly   371 CPAKTYQQNI 380
            ..|::...::
Zfish   382 LAAESVDSSL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	116/304 (38%)
		S_TKc	14..272	CDD:214567	107/271 (39%)
		CaMKII_AD	390..517	CDD:285524
phkg1a	NP_001071080.1	STKc_PhKG1	16..291	CDD:271084	109/279 (39%)
phkg1a	NP_001071080.1	S_TKc	20..288	CDD:214567	107/271 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920